OR52K2

Summary

OR52K2 (olfactory receptor family 52 subfamily K member 2, HGNC:15223) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 52K2 (Q8NGK3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 119774 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_001005172

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15223
Approved symbol	OR52K2
Name	olfactory receptor family 52 subfamily K member 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181963
Ensembl biotype	protein_coding
Entrez	119774

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000325719

RefSeq mRNA: 1 — MANE Select: NM_001005172 NM_001005172

CCDS: CCDS31351

Canonical transcript exons

ENST00000325719 — 1 exons

Exon	Start	End
ENSE00001267893	4449295	4450361

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 55.82.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	55.82	gold quality
leukocyte	CL:0000738	55.23	gold quality
bone marrow cell	CL:0002092	52.26	gold quality
blood	UBERON:0000178	44.36	gold quality
granulocyte	CL:0000094	37.22	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	34.93	gold quality
muscle tissue	UBERON:0002385	32.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
corpus callosum	UBERON:0002336	29.87	gold quality
vermiform appendix	UBERON:0001154	29.84	silver quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
gall bladder	UBERON:0002110	28.96	silver quality
tonsil	UBERON:0002372	28.94	gold quality
duodenum	UBERON:0002114	28.14	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.58	gold quality
lymph node	UBERON:0000029	27.57	gold quality
adrenal tissue	UBERON:0018303	27.57	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.23	gold quality
calcaneal tendon	UBERON:0003701	24.98	gold quality
left ovary	UBERON:0002119	24.73	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or52k2	ENSMUSG00000073973
rattus_norvegicus	Or52k2	ENSRNOG00000018508

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 52K2 — Q8NGK3 (reviewed: Q8NGK3)

Alternative names: Olfactory receptor OR11-7

All UniProt accessions (2): Q8NGK3, A0A126GVK8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005172* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGK3-F1	87.42	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 99–191

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, ZNF490_TARGET_GENES, HARALAMBIEVA_PBMC_M_M_R_II_AGE_11_22YO_VACCINATED_VS_UNVACCINATED_7YR_UP, OSMAN_BLOOD_CHAD63_KH_AGE_18_50YO_HIGH_DOSE_SUBJECTS_24HR_UP, REACTOME_SENSORY_PERCEPTION

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), nervous system process (GO:0050877), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
system process	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

248 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR52K2	VN1R4	Q7Z5H5	507
OR52K2	TAAR5	O14804	482
OR52K2	TAS2R31	P59538	479
OR52K2	VN1R2	Q8NFZ6	473
OR52K2	TAS2R43	P59537	448
OR52K2	OR1J2	Q8NGS2	411
OR52K2	VN1R1	Q9GZP7	400
OR52K2	TAS2R50	P59544	396
OR52K2	TAS2R13	Q9NYV9	370
OR52K2	ADGRF3	Q8IZF5	369
OR52K2	TAS2R5	Q9NYW4	348
OR52K2	TAS2R16	Q9NYV7	348
OR52K2	TAAR1	Q96RJ0	340
OR52K2	OR2C1	O95371	334
OR52K2	TAS2R10	Q9NYW0	326
OR52K2	TAS1R3	Q7RTX0	326

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR52K2	ZC2HC1B	psi-mi:“MI:0914”(association)	0.350

BioGRID (3): PURB (Affinity Capture-MS), SDR9C7 (Affinity Capture-MS), ZC2HC1B (Affinity Capture-MS)

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	65
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

341 predictions. Top by Δscore:

Variant	Effect	Δscore
11:4450014:GGCA:G	acceptor_gain	0.7800
11:4450011:TCAGG:T	acceptor_loss	0.7000
11:4450013:AGGCA:A	acceptor_loss	0.7000
11:4450009:CTTCA:C	acceptor_loss	0.6900
11:4450078:A:G	donor_gain	0.6900
11:4449895:GTG:G	donor_gain	0.6700
11:4450258:G:GT	donor_gain	0.6700
11:4449986:T:TG	donor_gain	0.6300
11:4449898:G:GG	donor_gain	0.6200
11:4450013:A:AG	acceptor_gain	0.6200
11:4450014:G:GG	acceptor_gain	0.6200
11:4450014:GGC:G	acceptor_gain	0.6100
11:4450016:C:T	donor_gain	0.6100
11:4449876:C:G	donor_gain	0.6000
11:4450015:G:GT	donor_gain	0.6000
11:4449711:C:G	donor_gain	0.5900
11:4449894:TGTGG:T	donor_loss	0.5900
11:4449895:GTGG:G	donor_loss	0.5900
11:4449896:TGGT:T	donor_loss	0.5900
11:4449898:G:GA	donor_loss	0.5900
11:4449899:T:G	donor_loss	0.5900
11:4449986:T:G	donor_gain	0.5900
11:4450113:C:A	donor_gain	0.5900
11:4449320:G:GT	donor_gain	0.5800
11:4449900:G:GG	donor_loss	0.5800
11:4450017:A:AA	donor_gain	0.5800
11:4449885:A:G	donor_gain	0.5700
11:4449897:G:GA	donor_gain	0.5700
11:4449832:CTG:C	acceptor_gain	0.5600
11:4449836:G:GT	donor_gain	0.5500

AlphaMissense

2044 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:4449699:G:A	M120I	0.941
11:4449699:G:C	M120I	0.941
11:4449699:G:T	M120I	0.941
11:4449710:G:C	R124P	0.937
11:4450214:T:A	I292K	0.932
11:4449649:T:C	F104L	0.922
11:4449651:C:A	F104L	0.922
11:4449651:C:G	F104L	0.922
11:4449707:A:T	D123V	0.911
11:4450096:T:C	F253L	0.911
11:4450098:C:A	F253L	0.911
11:4450098:C:G	F253L	0.911
11:4449707:A:C	D123A	0.910
11:4450209:T:A	N290K	0.909
11:4450209:T:G	N290K	0.909
11:4449439:T:C	C34R	0.907
11:4449708:C:A	D123E	0.904
11:4449708:C:G	D123E	0.904
11:4450053:G:C	K238N	0.904
11:4450053:G:T	K238N	0.904
11:4449471:C:A	N44K	0.901
11:4449471:C:G	N44K	0.901
11:4449974:A:C	D212A	0.900
11:4450241:T:C	I301T	0.896
11:4449379:T:C	F14L	0.894
11:4449381:C:A	F14L	0.894
11:4449381:C:G	F14L	0.894
11:4449554:A:C	D72A	0.891
11:4450214:T:G	I292R	0.890
11:4449718:G:C	A127P	0.887

dbSNP variants (sampled 300 via entrez): RS1000642648 (11:4450186 C>A,G), RS1003135873 (11:4449278 T>A,C), RS1003771393 (11:4447912 G>T), RS1004228426 (11:4448093 C>A), RS1004374654 (11:4447899 G>A), RS1004395577 (11:4448415 A>C), RS1004647144 (11:4448661 G>A), RS1005242708 (11:4447664 A>G), RS1005396632 (11:4448971 A>C,G), RS1005512794 (11:4448676 G>A), RS1007086114 (11:4447345 G>A), RS1007738209 (11:4449849 C>A,T), RS1007753030 (11:4450446 G>A), RS1010870564 (11:4448136 AT>A,ATT), RS1010967848 (11:4448049 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST004748_21	Lung cancer	8.000000e-06
GCST008038_14	Mean corpuscular hemoglobin concentration	5.000000e-11
GCST008038_7	Mean corpuscular hemoglobin concentration	3.000000e-12
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004528	mean corpuscular hemoglobin concentration

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Air Pollutants	increases abundance, affects expression	1
Benzo(a)pyrene	increases methylation	1
Copper	decreases expression, affects cotreatment	1
Folic Acid	decreases expression	1
Ozone	affects expression, increases abundance	1
Pesticides	decreases expression	1
Silicon Dioxide	increases expression	1
Tretinoin	increases expression	1
Valproic Acid	decreases methylation	1
Sodium Selenite	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.