OR52M1

Summary

OR52M1 (olfactory receptor family 52 subfamily M member 1, HGNC:15225) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 52M1 (Q8NGK5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 119772 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 84 total
• MANE Select transcript: NM_001004137

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15225
Approved symbol	OR52M1
Name	olfactory receptor family 52 subfamily M member 1
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000197790
Ensembl biotype	protein_coding
Entrez	119772

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000360213

RefSeq mRNA: 1 — MANE Select: NM_001004137 NM_001004137

CCDS: CCDS31353

Canonical transcript exons

ENST00000360213 — 1 exons

Exon	Start	End
ENSE00001420191	4545191	4546144

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 38.85.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	38.85	gold quality
ganglionic eminence	UBERON:0004023	37.80	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
skeletal muscle tissue	UBERON:0001134	34.96	gold quality
bone marrow	UBERON:0002371	34.38	gold quality
muscle tissue	UBERON:0002385	32.22	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.60	gold quality
leukocyte	CL:0000738	29.42	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.85	gold quality
duodenum	UBERON:0002114	28.14	gold quality
blood	UBERON:0000178	27.58	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.87	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
calcaneal tendon	UBERON:0003701	25.29	gold quality
muscle of leg	UBERON:0001383	25.00	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
pancreas	UBERON:0001264	23.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• This publication uses ‘GPR135’ as a name for this gene. (PMID:12732197)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or52m1	ENSMUSG00000073971
rattus_norvegicus	Or52m1	ENSRNOG00000070164

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 52M1 — Q8NGK5 (reviewed: Q8NGK5)

Alternative names: Olfactory receptor OR11-11

All UniProt accessions (1): Q8NGK5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004137* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGK5-F1	88.07	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 99–192

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, GSE22313_HEALTHY_VS_SLE_MOUSE_CD4_TCELL_UP

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), nervous system process (GO:0050877), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
system process	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

294 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR52M1	VN1R4	Q7Z5H5	480
OR52M1	PABIR3	Q6P4D5	476
OR52M1	VN1R2	Q8NFZ6	448
OR52M1	CYLC2	Q14093	434
OR52M1	RIBC1	Q8N443	417
OR52M1	VN1R1	Q9GZP7	395
OR52M1	SFT2D1	Q8WV19	372
OR52M1	PBDC1	Q9BVG4	371
OR52M1	ZNF714	Q96N38	370
OR52M1	KIAA0513	O60268	368
OR52M1	TAS2R13	Q9NYV9	366
OR52M1	ARHGEF38	Q9NXL2	360
OR52M1	YPEL4	Q96NS1	357
OR52M1	TXNDC16	Q9P2K2	355
OR52M1	RALGAPB	Q86X10	348

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

84 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	75
Likely benign	5
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

332 predictions. Top by Δscore:

Variant	Effect	Δscore
11:4545978:T:A	acceptor_gain	0.7800
11:4546075:T:G	acceptor_gain	0.7300
11:4546054:A:AG	acceptor_gain	0.7000
11:4545986:C:CA	acceptor_gain	0.6900
11:4546061:A:AG	acceptor_gain	0.6800
11:4545955:T:G	acceptor_gain	0.6700
11:4545984:A:AG	acceptor_gain	0.6400
11:4545984:ACC:A	acceptor_gain	0.6400
11:4546055:A:G	acceptor_gain	0.6400
11:4545525:T:G	donor_gain	0.6300
11:4546074:AT:A	acceptor_gain	0.6300
11:4545425:A:AG	acceptor_gain	0.6200
11:4546086:C:G	acceptor_gain	0.6200
11:4546078:T:A	acceptor_gain	0.6100
11:4545962:A:AG	acceptor_gain	0.6000
11:4545996:AGTGT:A	acceptor_gain	0.6000
11:4545997:GTGTG:G	acceptor_gain	0.6000
11:4546075:T:TA	acceptor_gain	0.6000
11:4545372:T:G	donor_gain	0.5900
11:4545997:GTGT:G	acceptor_gain	0.5900
11:4546085:A:AG	acceptor_gain	0.5800
11:4545962:ATT:A	acceptor_gain	0.5700
11:4546082:C:CA	acceptor_gain	0.5700
11:4545985:C:G	acceptor_gain	0.5600
11:4545428:A:AG	acceptor_gain	0.5500
11:4545967:T:A	acceptor_gain	0.5500
11:4545991:T:TA	acceptor_gain	0.5500
11:4545996:A:AG	acceptor_gain	0.5500
11:4545997:G:GG	acceptor_gain	0.5500
11:4545997:GT:G	acceptor_gain	0.5400

AlphaMissense

2049 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:4545561:G:C	R124P	0.951
11:4545500:T:C	F104L	0.948
11:4545502:C:A	F104L	0.948
11:4545502:C:G	F104L	0.948
11:4545950:T:C	F254L	0.947
11:4545952:T:A	F254L	0.947
11:4545952:T:G	F254L	0.947
11:4545550:G:A	M120I	0.940
11:4545550:G:C	M120I	0.940
11:4545550:G:T	M120I	0.940
11:4545827:G:C	D213H	0.938
11:4545800:A:C	S204R	0.930
11:4545802:C:A	S204R	0.930
11:4545802:C:G	S204R	0.930
11:4545828:A:C	D213A	0.930
11:4545828:A:T	D213V	0.925
11:4545496:A:C	Q102H	0.920
11:4545496:A:T	Q102H	0.920
11:4545720:T:C	I177T	0.920
11:4545487:C:G	C99W	0.917
11:4546063:T:A	N291K	0.917
11:4546063:T:G	N291K	0.917
11:4545829:C:A	D213E	0.916
11:4545829:C:G	D213E	0.916
11:4545861:T:C	I224T	0.916
11:4546071:T:A	V294D	0.914
11:4545573:T:A	I128N	0.906
11:4545246:T:C	I19T	0.902
11:4545738:A:T	E183V	0.901
11:4545720:T:G	I177S	0.899

dbSNP variants (sampled 300 via entrez): RS1000838658 (11:4546631 T>C), RS1001425321 (11:4543229 T>C), RS1001603139 (11:4544723 G>A), RS1002097881 (11:4544929 T>C), RS1003014199 (11:4545624 G>A,C,T), RS1005045337 (11:4544492 G>A,T), RS1005480304 (11:4544524 G>A), RS1006469616 (11:4543373 G>C), RS1006784897 (11:4543302 C>A,G), RS1006891700 (11:4543593 T>C), RS1007051995 (11:4544233 A>C,G), RS1009539827 (11:4544243 C>A,T), RS1010989210 (11:4544979 G>C), RS1011590003 (11:4545116 ATT>A), RS1012730285 (11:4544531 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST001762_322	Obesity-related traits	4.000000e-06
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation	1
arsenite	decreases methylation	1
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.