OR52N1

Summary

OR52N1 (olfactory receptor family 52 subfamily N member 1, HGNC:14853) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 52N1 (Q8NH53). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 79473 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 45 total
• MANE Select transcript: NM_001001913

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14853
Approved symbol	OR52N1
Name	olfactory receptor family 52 subfamily N member 1
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181001
Ensembl biotype	protein_coding
Entrez	79473

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641645

RefSeq mRNA: 1 — MANE Select: NM_001001913 NM_001001913

CCDS: CCDS31398

Canonical transcript exons

ENST00000641645 — 2 exons

Exon	Start	End
ENSE00003812763	5791111	5791265
ENSE00003813227	5786471	5788860

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 80.07.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.07	gold quality
lower esophagus mucosa	UBERON:0035834	45.22	silver quality
gall bladder	UBERON:0002110	42.10	silver quality
colonic epithelium	UBERON:0000397	41.84	gold quality
calcaneal tendon	UBERON:0003701	41.74	gold quality
sural nerve	UBERON:0015488	40.58	gold quality
hindlimb stylopod muscle	UBERON:0004252	39.70	silver quality
skeletal muscle tissue	UBERON:0001134	36.51	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
omental fat pad	UBERON:0010414	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
granulocyte	CL:0000094	34.85	gold quality
muscle tissue	UBERON:0002385	34.66	gold quality
bone marrow	UBERON:0002371	32.92	gold quality
lymph node	UBERON:0000029	32.19	gold quality
mucosa of stomach	UBERON:0001199	32.05	gold quality
leukocyte	CL:0000738	30.92	gold quality
adipose tissue	UBERON:0001013	30.77	gold quality
monocyte	CL:0000576	30.70	gold quality
prefrontal cortex	UBERON:0000451	30.11	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
superior frontal gyrus	UBERON:0002661	29.59	gold quality
vermiform appendix	UBERON:0001154	29.27	gold quality
fundus of stomach	UBERON:0001160	29.18	gold quality
urinary bladder	UBERON:0001255	28.83	gold quality
blood	UBERON:0000178	28.74	gold quality
tonsil	UBERON:0002372	28.62	gold quality
smooth muscle tissue	UBERON:0001135	28.33	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.12
E-MTAB-6142	no	1.64

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or52n1	ENSMUSG00000051885
rattus_norvegicus	Or52n1	ENSRNOG00000077473
rattus_norvegicus	Or52n1b	ENSRNOG00000079091

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 52N1 — Q8NH53 (reviewed: Q8NH53)

Alternative names: Olfactory receptor OR11-61

All UniProt accessions (1): Q8NH53

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001913* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 5, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH53-F1	89.09	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 99–191

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), nervous system process (GO:0050877), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
system process	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

134 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR52N1	OVCH2	Q7RTZ1	648
OR52N1	CNTN5	O94779	495
OR52N1	SYT6	Q5T7P8	411
OR52N1	KRTAP19-8	Q3LI54	401
OR52N1	TRIP11	Q15643	385
OR52N1	FAM131A	Q6UXB0	305
OR52N1	KRTAP5-7	Q6L8G8	305
OR52N1	USP17L25	Q0WX57	301
OR52N1	TAS2R42	Q7RTR8	279
OR52N1	LLPH	Q9BRT6	271
OR52N1	KRTAP5-11	Q6L8G4	249
OR52N1	USP17L2	Q6R6M4	247
OR52N1	ZNF429	Q86V71	247
OR52N1	KRTAP5-5	Q701N2	245
OR52N1	COL6A5	A8TX70	239

IntAct

0 interactions, top by confidence:

BioGRID (1): OR52N1 (Affinity Capture-MS)

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

45 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

412 predictions. Top by Δscore:

Variant	Effect	Δscore
11:5788688:C:A	donor_gain	0.9500
11:5788676:AAGG:A	donor_gain	0.8700
11:5788710:A:C	donor_gain	0.8600
11:5788705:TG:T	donor_gain	0.7900
11:5788749:T:TA	donor_gain	0.7500
11:5788749:TCCAA:T	donor_gain	0.7300
11:5788151:CATAG:C	acceptor_gain	0.6900
11:5788684:AGTTC:A	donor_gain	0.6700
11:5788634:CATA:C	donor_gain	0.6600
11:5788634:CATAG:C	donor_gain	0.6600
11:5788637:AGGT:A	donor_gain	0.6400
11:5788655:A:AC	donor_gain	0.6400
11:5788709:CATG:C	donor_gain	0.6400
11:5788634:CA:C	donor_gain	0.6200
11:5788656:T:C	donor_gain	0.6200
11:5788600:CAT:C	acceptor_gain	0.6100
11:5788242:C:CT	donor_gain	0.6000
11:5788603:C:CC	acceptor_gain	0.6000
11:5788634:CAT:C	donor_gain	0.6000
11:5788484:C:A	donor_gain	0.5800
11:5788746:T:C	donor_gain	0.5700
11:5788710:ATGG:A	donor_gain	0.5500
11:5788711:TGGT:T	donor_gain	0.5500
11:5788155:G:GC	acceptor_gain	0.5300
11:5788206:A:C	acceptor_gain	0.5300
11:5788138:C:CC	acceptor_gain	0.5200
11:5788380:G:C	donor_gain	0.5100
11:5788554:C:CT	acceptor_gain	0.5100
11:5788252:T:C	donor_gain	0.5000
11:5788629:ACAT:A	donor_loss	0.5000

AlphaMissense

2127 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:5788505:G:C	F104L	0.766
11:5788505:G:T	F104L	0.766
11:5788507:A:G	F104L	0.766
11:5788775:G:C	F14L	0.760
11:5788775:G:T	F14L	0.760
11:5788777:A:G	F14L	0.760
11:5788583:G:C	S78R	0.706
11:5788583:G:T	S78R	0.706
11:5788585:T:G	S78R	0.706
11:5788529:A:C	F96L	0.695
11:5788529:A:T	F96L	0.695
11:5788531:A:G	F96L	0.695
11:5788703:G:C	S38R	0.692
11:5788703:G:T	S38R	0.692
11:5788705:T:G	S38R	0.692
11:5788019:A:C	F266L	0.683
11:5788019:A:T	F266L	0.683
11:5788021:A:G	F266L	0.683
11:5788550:A:C	F89L	0.651
11:5788550:A:T	F89L	0.651
11:5788552:A:G	F89L	0.651
11:5788625:G:C	F64L	0.640
11:5788625:G:T	F64L	0.640
11:5788627:A:G	F64L	0.640
11:5788717:A:G	C34R	0.615
11:5788735:A:G	W28R	0.564
11:5788735:A:T	W28R	0.564

dbSNP variants (sampled 300 via entrez): RS1000343290 (11:5787331 G>A,C), RS1000706209 (11:5788665 A>C,G), RS1000777945 (11:5788979 T>G), RS1001110853 (11:5788922 C>A,T), RS1001226268 (11:5788047 G>C), RS1002222468 (11:5789258 T>C), RS1002401843 (11:5789954 C>T), RS1003072444 (11:5792490 A>G), RS1003105152 (11:5792746 ATCTC>A,ATC), RS1003886506 (11:5792720 C>G,T), RS1005231909 (11:5788142 T>A,C), RS1005236781 (11:5790756 G>A,T), RS1005827094 (11:5789281 C>G), RS1006212011 (11:5789647 T>C), RS1006500978 (11:5792241 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	2
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
Benzo(a)pyrene	affects methylation	1
Copper	affects cotreatment, decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.