OR52N2

Summary

OR52N2 (olfactory receptor family 52 subfamily N member 2, HGNC:15228) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 52N2 (Q8NGI0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390077 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001005174

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15228
Approved symbol	OR52N2
Name	olfactory receptor family 52 subfamily N member 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000180988
Ensembl biotype	protein_coding
Entrez	390077

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000317037, ENST00000913289, ENST00000913290

RefSeq mRNA: 1 — MANE Select: NM_001005174 NM_001005174

CCDS: CCDS31399

Canonical transcript exons

ENST00000317037 — 2 exons

Exon	Start	End
ENSE00001256465	5820282	5821483
ENSE00003921658	5808924	5809054

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 83.25.

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.25	gold quality
granulocyte	CL:0000094	44.67	silver quality
islet of Langerhans	UBERON:0000006	44.01	gold quality
gall bladder	UBERON:0002110	40.08	gold quality
tibial nerve	UBERON:0001323	38.91	gold quality
bone marrow cell	CL:0002092	38.29	gold quality
apex of heart	UBERON:0002098	37.47	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
mucosa of stomach	UBERON:0001199	36.39	silver quality
hindlimb stylopod muscle	UBERON:0004252	36.16	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
bone marrow	UBERON:0002371	35.35	gold quality
lymph node	UBERON:0000029	33.26	silver quality
right uterine tube	UBERON:0001302	33.13	gold quality
prefrontal cortex	UBERON:0000451	32.87	gold quality
pancreas	UBERON:0001264	32.68	gold quality
fallopian tube	UBERON:0003889	32.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	32.01	gold quality
spleen	UBERON:0002106	31.45	gold quality
tibial artery	UBERON:0007610	31.03	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
popliteal artery	UBERON:0002250	30.92	gold quality
thoracic mammary gland	UBERON:0005200	30.69	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	30.46	gold quality
superior frontal gyrus	UBERON:0002661	30.22	gold quality
placenta	UBERON:0001987	29.93	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
adipose tissue	UBERON:0001013	29.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.30

Regulation

Is transcription factor: no

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or52n2b	ENSMUSG00000056782
mus_musculus	Or52n2c	ENSMUSG00000057770
mus_musculus	Or52n2	ENSMUSG00000063582
rattus_norvegicus	Or52n2	ENSRNOG00000071862
rattus_norvegicus	Or52n2e	ENSRNOG00000077047
rattus_norvegicus		ENSRNOG00000085363
rattus_norvegicus	Or52n2b	ENSRNOG00000091068

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 52N2 — Q8NGI0 (reviewed: Q8NGI0)

Alternative names: Olfactory receptor OR11-57

All UniProt accessions (1): Q8NGI0

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005174* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGI0-F1	89.62	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 99–191

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr11p15

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), nervous system process (GO:0050877), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
system process	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

92 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR52N2	GPN1	Q9HCN4	544
OR52N2	LHPP	Q9H008	479
OR52N2	CLPTM1L	Q96KA5	419
OR52N2	LAMC3	Q9Y6N6	403
OR52N2	MATN4	O95460	356
OR52N2	FGFR1OP2	Q9NVK5	346
OR52N2	TRIM5	Q9C035	318
OR52N2	STK40	Q8N2I9	315
OR52N2	TUBAL3	A6NHL2	312
OR52N2	MAGEA6	P43360	290
OR52N2	SERPINB8	P50452	276
OR52N2	HLA-DQB1	P01917	269
OR52N2	ADH1B	P00325	250
OR52N2	PARP15	Q460N3	248
OR52N2	CCDC121	Q6ZUS5	245

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

197 predictions. Top by Δscore:

Variant	Effect	Δscore
11:5820996:ACTAT:A	acceptor_gain	0.8800
11:5820996:A:AG	acceptor_gain	0.8300
11:5820896:CAAG:C	donor_loss	0.7200
11:5820897:AAGG:A	donor_loss	0.7200
11:5820898:AG:A	donor_loss	0.7200
11:5820900:G:GA	donor_loss	0.7200
11:5820901:T:C	donor_loss	0.7200
11:5820997:C:G	acceptor_gain	0.7200
11:5821000:T:TA	acceptor_gain	0.7100
11:5821010:GGCT:G	acceptor_gain	0.7100
11:5821009:AG:A	acceptor_gain	0.6900
11:5821010:GG:G	acceptor_gain	0.6900
11:5820795:A:T	donor_gain	0.6800
11:5820902:A:T	donor_loss	0.6800
11:5820922:TCA:T	donor_gain	0.6700
11:5820923:C:A	donor_gain	0.6700
11:5820999:AT:A	acceptor_gain	0.6700
11:5821009:A:AG	acceptor_gain	0.6700
11:5821010:G:GG	acceptor_gain	0.6700
11:5820794:G:GT	donor_gain	0.6500
11:5820925:A:G	donor_gain	0.6500
11:5820577:C:G	donor_gain	0.6400
11:5821000:T:G	acceptor_gain	0.6400
11:5820964:T:A	donor_gain	0.6200
11:5821005:TTGCA:T	acceptor_loss	0.6200
11:5821006:TGCAG:T	acceptor_loss	0.6200
11:5821007:GCAG:G	acceptor_loss	0.6200
11:5821008:CA:C	acceptor_loss	0.6200
11:5820521:C:CG	donor_gain	0.5900
11:5820570:AT:A	donor_gain	0.5800

AlphaMissense

2138 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:5820695:G:A	M120I	0.849
11:5820695:G:C	M120I	0.849
11:5820695:G:T	M120I	0.849
11:5820645:T:C	F104L	0.834
11:5820647:T:A	F104L	0.834
11:5820647:T:G	F104L	0.834
11:5821049:A:C	K238N	0.830
11:5821049:A:T	K238N	0.830
11:5820706:G:C	R124P	0.826
11:5821003:T:C	I223T	0.808
11:5820703:A:T	D123V	0.801
11:5820703:A:C	D123A	0.798
11:5821240:T:C	I302T	0.781
11:5821216:T:A	V294D	0.768
11:5820467:C:A	N44K	0.764
11:5820467:C:G	N44K	0.764
11:5820704:C:A	D123E	0.761
11:5820704:C:G	D123E	0.761
11:5821011:G:C	A226P	0.759
11:5820382:T:C	L16S	0.748
11:5820970:A:C	D212A	0.745
11:5820435:T:C	C34R	0.743
11:5820621:T:C	F96L	0.741
11:5820623:T:A	F96L	0.741
11:5820623:T:G	F96L	0.741
11:5820971:T:A	D212E	0.740
11:5820971:T:G	D212E	0.740
11:5820797:T:A	N154K	0.735
11:5820797:T:G	N154K	0.735
11:5821131:T:C	F266L	0.734

dbSNP variants (sampled 300 via entrez): RS1000017003 (11:5811564 A>C), RS1000151819 (11:5820411 C>A,T), RS1000403189 (11:5816302 T>C,G), RS1000753862 (11:5821457 C>A,T), RS1000872282 (11:5810315 G>C,T), RS1000921607 (11:5821427 G>A), RS1000971922 (11:5821751 A>G), RS1000976048 (11:5821813 C>T), RS1001092214 (11:5816064 G>T), RS1001642520 (11:5812582 C>A), RS1001693571 (11:5812854 C>T), RS1001740267 (11:5810962 G>A), RS1001975496 (11:5810676 G>A), RS1002543968 (11:5815694 A>T), RS1002741073 (11:5812258 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST003857_3	Oral cavity and pharyngeal cancer	5.000000e-08
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Amiodarone	increases expression	1
Atrazine	increases expression	1
Cadmium	increases abundance, decreases expression	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.