OR52N5

Summary

OR52N5 (olfactory receptor family 52 subfamily N member 5, HGNC:15231) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 52N5 (Q8NH56). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390075 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 49 total
• MANE Select transcript: NM_001385662

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15231
Approved symbol	OR52N5
Name	olfactory receptor family 52 subfamily N member 5
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	OR52N5Q
Ensembl gene	ENSG00000181009
Ensembl biotype	protein_coding
Entrez	390075

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000317093, ENST00000641181

RefSeq mRNA: 2 — MANE Select: NM_001385662 NM_001001922, NM_001385662

CCDS: CCDS31397

Canonical transcript exons

ENST00000641181 — 3 exons

Exon	Start	End
ENSE00003812152	5781533	5781756
ENSE00003812318	5776165	5778657
ENSE00003813160	5783295	5783355

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 57.73.

Top tissues by expression

112 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.73	gold quality
calcaneal tendon	UBERON:0003701	44.28	silver quality
colonic epithelium	UBERON:0000397	42.50	gold quality
lower esophagus mucosa	UBERON:0035834	41.70	silver quality
sural nerve	UBERON:0015488	41.10	silver quality
bone marrow cell	CL:0002092	40.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	39.79	silver quality
placenta	UBERON:0001987	37.12	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
omental fat pad	UBERON:0010414	35.58	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
bone marrow	UBERON:0002371	34.98	gold quality
left uterine tube	UBERON:0001303	33.76	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
muscle tissue	UBERON:0002385	32.27	gold quality
monocyte	CL:0000576	31.30	gold quality
endometrium	UBERON:0001295	31.06	gold quality
leukocyte	CL:0000738	30.96	gold quality
tonsil	UBERON:0002372	30.63	gold quality
adipose tissue	UBERON:0001013	30.22	gold quality
fallopian tube	UBERON:0003889	29.88	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.34	gold quality
adrenal tissue	UBERON:0018303	29.10	gold quality
gall bladder	UBERON:0002110	29.08	silver quality
corpus callosum	UBERON:0002336	29.03	gold quality
duodenum	UBERON:0002114	28.14	gold quality
blood	UBERON:0000178	28.04	gold quality
urinary bladder	UBERON:0001255	27.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.60

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or52n5	ENSMUSG00000073916

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 52N5 — Q8NH56 (reviewed: Q8NH56)

Alternative names: Olfactory receptor OR11-62

All UniProt accessions (2): A0A126GVK9, Q8NH56

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001001922, NP_001372591* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH56-F1	85.37	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 106–198

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr11p15

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), nervous system process (GO:0050877), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
system process	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

170 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR52N5	RALYL	Q86SE5	711
OR52N5	OVCH2	Q7RTZ1	645
OR52N5	CNTN5	O94779	491
OR52N5	HNRNPCL3	B7ZW38	475
OR52N5	HNRNPCL2	B2RXH8	475
OR52N5	TIGD3	Q6B0B8	474
OR52N5	ADGRF3	Q8IZF5	419
OR52N5	SERHL2	Q9H4I8	417
OR52N5	SYT6	Q5T7P8	405
OR52N5	TTLL1	O95922	403
OR52N5	CRNKL1	Q9BZJ0	389
OR52N5	SLC25A17	O43808	389
OR52N5	TRIP11	Q15643	379
OR52N5	A4GALT	Q9NPC4	362
OR52N5	HNRNPCL1	O60812	355

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR52N5	ART1	psi-mi:“MI:0914”(association)	0.350

BioGRID (4): SHARPIN (Affinity Capture-MS), CD226 (Affinity Capture-MS), ABHD8 (Affinity Capture-MS), ART1 (Affinity Capture-MS)

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	43
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

212 predictions. Top by Δscore:

Variant	Effect	Δscore
11:5777948:CAAAG:C	acceptor_gain	0.9800
11:5777952:G:GC	acceptor_gain	0.9600
11:5777952:G:C	acceptor_gain	0.9500
11:5777949:A:T	acceptor_gain	0.9200
11:5777940:T:TC	acceptor_gain	0.8300
11:5777940:T:C	acceptor_gain	0.7700
11:5777954:G:C	acceptor_gain	0.7600
11:5778588:G:C	donor_gain	0.7600
11:5778643:T:A	donor_gain	0.7600
11:5777954:G:GC	acceptor_gain	0.7500
11:5778549:T:A	donor_gain	0.6900
11:5778544:CT:C	donor_gain	0.6800
11:5778593:A:C	donor_gain	0.6800
11:5778120:A:C	donor_gain	0.6500
11:5777938:CCT:C	acceptor_gain	0.6300
11:5778543:A:AC	donor_gain	0.6300
11:5778544:C:CC	donor_gain	0.6300
11:5777939:C:CC	acceptor_gain	0.6100
11:5777967:A:C	acceptor_gain	0.6100
11:5778510:A:C	donor_gain	0.6100
11:5778538:CAT:C	donor_gain	0.6100
11:5777935:CTGC:C	acceptor_gain	0.5900
11:5778537:A:AC	donor_gain	0.5800
11:5778538:C:CC	donor_gain	0.5800
11:5778055:C:CT	donor_gain	0.5700
11:5778056:T:TT	donor_gain	0.5700
11:5778635:T:A	donor_gain	0.5700
11:5777936:TGC:T	acceptor_gain	0.5600
11:5778118:TA:T	donor_gain	0.5600
11:5778119:AA:A	donor_gain	0.5600

AlphaMissense

2133 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:5778104:G:C	F177L	0.808
11:5778104:G:T	F177L	0.808
11:5778106:A:G	F177L	0.808
11:5777816:A:C	F273L	0.766
11:5777816:A:T	F273L	0.766
11:5777818:A:G	F273L	0.766
11:5778302:G:C	F111L	0.745
11:5778302:G:T	F111L	0.745
11:5778304:A:G	F111L	0.745
11:5778575:A:C	F20L	0.681
11:5778575:A:T	F20L	0.681
11:5778577:A:G	F20L	0.681
11:5778326:G:C	F103L	0.677
11:5778326:G:T	F103L	0.677
11:5778328:A:G	F103L	0.677
11:5777831:G:C	F268L	0.660
11:5777831:G:T	F268L	0.660
11:5777833:A:G	F268L	0.660
11:5778347:G:C	F96L	0.650
11:5778347:G:T	F96L	0.650
11:5778349:A:G	F96L	0.650
11:5777894:G:C	F247L	0.649
11:5777894:G:T	F247L	0.649
11:5777896:A:G	F247L	0.649
11:5778353:G:C	F94L	0.647
11:5778353:G:T	F94L	0.647
11:5778355:A:G	F94L	0.647
11:5778535:A:G	W34R	0.641
11:5778535:A:T	W34R	0.641
11:5778517:A:G	C40R	0.632

dbSNP variants (sampled 300 via entrez): RS1000163797 (11:5783933 C>A), RS1000495427 (11:5782719 C>T), RS1001689012 (11:5781012 A>G), RS1001790192 (11:5778654 C>T), RS1002452738 (11:5783138 G>A), RS1003058495 (11:5783258 G>C), RS1003065940 (11:5777154 T>A), RS1003703453 (11:5784208 G>A,C), RS1004875153 (11:5779536 CT>C), RS1005478797 (11:5776213 T>C), RS1005620482 (11:5783509 A>G), RS1005755663 (11:5775875 A>T), RS1006851766 (11:5784114 C>A), RS1006964824 (11:5776656 T>C), RS1007092221 (11:5783903 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	2
CGP 52608	affects binding, increases reaction	1
MT19c compound	increases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.