OR52W1

Summary

OR52W1 (olfactory receptor family 52 subfamily W member 1, HGNC:15239) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 52W1 (Q6IF63). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 120787 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_001005178

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15239
Approved symbol	OR52W1
Name	olfactory receptor family 52 subfamily W member 1
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000175485
Ensembl biotype	protein_coding
Entrez	120787

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000311352

RefSeq mRNA: 1 — MANE Select: NM_001005178 NM_001005178

CCDS: CCDS31407

Canonical transcript exons

ENST00000311352 — 1 exons

Exon	Start	End
ENSE00004472050	6199224	6200186

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 47.52.

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	47.52	gold quality
colonic epithelium	UBERON:0000397	42.39	gold quality
sural nerve	UBERON:0015488	41.54	gold quality
granulocyte	CL:0000094	40.01	gold quality
tonsil	UBERON:0002372	38.46	gold quality
skeletal muscle tissue	UBERON:0001134	37.96	gold quality
calcaneal tendon	UBERON:0003701	37.41	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
right coronary artery	UBERON:0001625	35.40	gold quality
prefrontal cortex	UBERON:0000451	35.34	silver quality
monocyte	CL:0000576	35.18	gold quality
leukocyte	CL:0000738	35.17	gold quality
muscle tissue	UBERON:0002385	34.43	gold quality
duodenum	UBERON:0002114	33.28	silver quality
cerebellar cortex	UBERON:0002129	32.63	gold quality
right uterine tube	UBERON:0001302	32.42	gold quality
urinary bladder	UBERON:0001255	32.36	gold quality
cerebellar hemisphere	UBERON:0002245	32.33	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
right hemisphere of cerebellum	UBERON:0014890	32.07	gold quality
transverse colon	UBERON:0001157	31.31	gold quality
descending thoracic aorta	UBERON:0002345	30.66	silver quality
lymph node	UBERON:0000029	30.46	gold quality
right lobe of thyroid gland	UBERON:0001119	30.14	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
rectum	UBERON:0001052	29.80	silver quality
placenta	UBERON:0001987	29.79	silver quality
vermiform appendix	UBERON:0001154	29.71	silver quality
nucleus accumbens	UBERON:0001882	29.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or52w1	ENSMUSG00000073906
rattus_norvegicus	Or52w1	ENSRNOG00000049480

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 52W1 — Q6IF63 (reviewed: Q6IF63)

Alternative names: Olfactory receptor OR11-71

All UniProt accessions (1): Q6IF63

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005178* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6IF63-F1	87.49	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 8

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ID1_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), nervous system process (GO:0050877), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
system process	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

242 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR52W1	SAP130	Q9H0E3	606
OR52W1	CNGA4	Q8IV77	601
OR52W1	CATSPER3	Q86XQ3	573
OR52W1	MSANTD1	Q6ZTZ1	571
OR52W1	SNUPN	O95149	528
OR52W1	GPR87	Q9BY21	498
OR52W1	ZNF772	Q68DY9	488
OR52W1	UGGT1	Q9NYU2	472
OR52W1	DMP1	Q13316	445
OR52W1	RDM1	Q8NG50	432
OR52W1	FASTKD3	Q14CZ7	427
OR52W1	STK31	Q9BXU1	426
OR52W1	GPR171	O14626	420
OR52W1	CCDC57	Q2TAC2	419
OR52W1	DNAJC12	Q9UKB3	418

IntAct

3 interactions, top by confidence:

A	B	Type	Score
OR52W1	PROZ	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (3): PROZ (Affinity Capture-MS), PROZ (Affinity Capture-MS), OR52W1 (Negative Genetic)

ESM2 similar proteins: A0A3B3IT45, A6NGY5, A6NMU1, B3DH96, O88628, P0C646, P0C7T3, Q5J3E5, Q5J3G9, Q5J3M9, Q5QD29, Q6IF63, Q6W049, Q8NGB9, Q8NGD3, Q8NGF0, Q8NGF1, Q8NGH6, Q8NGH7, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGJ4, Q8NGJ8, Q8NGJ9, Q8NGK5, Q8NGK6, Q8NGV6, Q8NH53, Q8NH55, Q8NH56, Q8NH60, Q8NH61, Q8NH63, Q8NH67, Q8NH76, Q8NHC6, Q8TCB6, Q8VBV9

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	49
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

198 predictions. Top by Δscore:

Variant	Effect	Δscore
11:6199994:C:G	acceptor_gain	0.7700
11:6199984:T:TA	acceptor_gain	0.7300
11:6200023:A:AG	acceptor_gain	0.7100
11:6200080:A:AG	acceptor_gain	0.6500
11:6199995:A:AG	acceptor_gain	0.6400
11:6200030:T:TA	acceptor_gain	0.6300
11:6200000:T:A	acceptor_gain	0.6200
11:6199997:ACCT:A	acceptor_gain	0.6100
11:6199300:G:GT	donor_gain	0.6000
11:6199947:GCCT:G	donor_gain	0.6000
11:6199993:A:AG	acceptor_gain	0.6000
11:6200020:C:G	acceptor_gain	0.6000
11:6200080:ACTT:A	acceptor_gain	0.6000
11:6200086:T:A	acceptor_gain	0.6000
11:6199985:G:A	acceptor_gain	0.5900
11:6200081:C:G	acceptor_gain	0.5900
11:6199996:T:G	acceptor_gain	0.5800
11:6200021:A:AG	acceptor_gain	0.5800
11:6200023:ACC:A	acceptor_gain	0.5800
11:6200024:C:G	acceptor_gain	0.5700
11:6200014:A:AG	acceptor_gain	0.5500
11:6200019:A:AG	acceptor_gain	0.5500
11:6199998:C:G	acceptor_gain	0.5300
11:6199961:T:TA	donor_gain	0.5200
11:6199962:A:AA	donor_gain	0.5200
11:6200015:C:G	acceptor_gain	0.5200
11:6200022:C:G	acceptor_gain	0.5200
11:6199849:T:A	acceptor_gain	0.5100
11:6200021:ACACC:A	acceptor_gain	0.5100
11:6200042:T:A	acceptor_gain	0.5100

AlphaMissense

2022 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:6199989:T:C	F256L	0.949
11:6199991:C:A	F256L	0.949
11:6199991:C:G	F256L	0.949
11:6200028:T:C	F269L	0.947
11:6200030:T:A	F269L	0.947
11:6200030:T:G	F269L	0.947
11:6199743:T:C	F174L	0.939
11:6199745:C:A	F174L	0.939
11:6199745:C:G	F174L	0.939
11:6199416:T:C	F65L	0.935
11:6199418:T:A	F65L	0.935
11:6199418:T:G	F65L	0.935
11:6199542:T:C	F107L	0.923
11:6199544:C:A	F107L	0.923
11:6199544:C:G	F107L	0.923
11:6199996:T:A	I258K	0.909
11:6199996:T:G	I258R	0.872
11:6199734:T:C	F171L	0.857
11:6199736:T:A	F171L	0.857
11:6199736:T:G	F171L	0.857
11:6200007:T:C	F262L	0.848
11:6200009:C:A	F262L	0.848
11:6200009:C:G	F262L	0.848
11:6199946:G:C	K241N	0.836
11:6199946:G:T	K241N	0.836
11:6199592:G:A	M123I	0.823
11:6199592:G:C	M123I	0.823
11:6199592:G:T	M123I	0.823
11:6200029:T:G	F269C	0.823
11:6200098:C:A	A292D	0.821

dbSNP variants (sampled 300 via entrez): RS1001617260 (11:6197287 T>A), RS1002620091 (11:6198790 T>C), RS1002630039 (11:6198460 C>T), RS1003628764 (11:6200176 G>T), RS1005588239 (11:6200488 T>C), RS1006056488 (11:6200247 G>A), RS1006414270 (11:6198808 C>A), RS1006723926 (11:6198419 A>G), RS1006875122 (11:6199701 ATTG>A), RS1007233607 (11:6199977 G>A,T), RS1008495409 (11:6198435 C>T), RS1008964072 (11:6198206 T>C), RS1009784078 (11:6200582 C>T), RS1012346339 (11:6200535 T>C), RS1015444635 (11:6197434 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Arsenic	affects methylation	1
Atrazine	increases expression	1
Benzo(a)pyrene	affects methylation	1
Plant Extracts	decreases expression, affects cotreatment	1
Aflatoxin B1	increases methylation	1
Sodium Selenite	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.