OR56A5

Summary

OR56A5 (olfactory receptor family 56 subfamily A member 5, HGNC:14792) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 56A5 (P0C7T3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390084 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• MANE Select transcript: NM_001146033

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14792
Approved symbol	OR56A5
Name	olfactory receptor family 56 subfamily A member 5
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000188691
Ensembl biotype	protein_coding
Entrez	390084

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000532411

RefSeq mRNA: 1 — MANE Select: NM_001146033 NM_001146033

CCDS: CCDS73248

Canonical transcript exons

ENST00000532411 — 1 exons

Exon	Start	End
ENSE00002177771	5967553	5968494

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 42.81.

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	42.81	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
sural nerve	UBERON:0015488	36.46	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
leukocyte	CL:0000738	30.01	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
urinary bladder	UBERON:0001255	29.42	gold quality
monocyte	CL:0000576	29.40	gold quality
prefrontal cortex	UBERON:0000451	29.26	gold quality
duodenum	UBERON:0002114	28.14	gold quality
placenta	UBERON:0001987	27.78	gold quality
blood	UBERON:0000178	27.61	gold quality
lymph node	UBERON:0000029	27.57	gold quality
rectum	UBERON:0001052	27.40	gold quality
calcaneal tendon	UBERON:0003701	27.37	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
muscle of leg	UBERON:0001383	25.08	gold quality
endometrium	UBERON:0001295	24.73	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.97

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	adra1ab	ENSDARG00000027638
danio_rerio	adra2db	ENSDARG00000054667
danio_rerio	adra2da	ENSDARG00000091277
caenorhabditis_elegans	ser-5	WBGENE00008890

Paralogs (18): ADRB1 (ENSG00000043591), ADRA1A (ENSG00000120907), DRD2 (ENSG00000149295), ADRA2A (ENSG00000150594), GPR101 (ENSG00000165370), ADRB2 (ENSG00000169252), ADRA1B (ENSG00000170214), ADRA1D (ENSG00000171873), OR5T3 (ENSG00000172489), OR56A1 (ENSG00000180934), OR5T1 (ENSG00000181698), OR5T2 (ENSG00000181718), OR56A4 (ENSG00000183389), ADRA2C (ENSG00000184160), OR56A3 (ENSG00000184478), OR13F1 (ENSG00000186881), ADRB3 (ENSG00000188778), ADRA2B (ENSG00000274286)

Protein

Protein identifiers

Olfactory receptor 56A5 — P0C7T3 (reviewed: P0C7T3)

All UniProt accessions (2): A0A126GWP3, P0C7T3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001139505* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, glycosylation site 4, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C7T3-F1	87.89	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 100–182

Glycosylation sites (4): 6, 7, 184, 198

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_RESPONSE_TO_LIPID, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (6): cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

98 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR56A5	REEP6	Q96HR9	522
OR56A5	GNGT1	P63211	492
OR56A5	TAS2R16	Q9NYV7	447
OR56A5	ADAM30	Q9UKF2	417
OR56A5	KBTBD13	C9JR72	400
OR56A5	ASB10	Q8WXI3	396
OR56A5	TAAR5	O14804	380
OR56A5	TRHR	P34981	310
OR56A5	SF3B4	Q15427	305
OR56A5	ADRA2C	P18825	296
OR56A5	KLHL5	Q96PQ7	237
OR56A5	OR4C13	Q8NGP0	232
OR56A5	GPR55	Q9Y2T6	231
OR56A5	ATP2B4	P23634	228
OR56A5	REEP4	Q9H6H4	226

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, A6NMU1, B3DH96, O88628, P0C646, P0C7T3, Q5J3E5, Q5J3G9, Q5J3M9, Q5QD29, Q6IF63, Q6W049, Q8NGB9, Q8NGD3, Q8NGF0, Q8NGF1, Q8NGH6, Q8NGH7, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGJ4, Q8NGJ8, Q8NGJ9, Q8NGK5, Q8NGK6, Q8NGV6, Q8NH53, Q8NH55, Q8NH56, Q8NH60, Q8NH61, Q8NH63, Q8NH67, Q8NH76, Q8NHC6, Q8TCB6, Q8VBV9

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

182 predictions. Top by Δscore:

Variant	Effect	Δscore
11:5968092:A:AC	donor_gain	0.9100
11:5968093:C:CC	donor_gain	0.9100
11:5968331:T:TA	donor_gain	0.8000
11:5967726:C:CC	acceptor_gain	0.7900
11:5967888:A:AC	donor_gain	0.7700
11:5967889:C:CC	donor_gain	0.7700
11:5968305:A:AC	donor_gain	0.7200
11:5968032:T:A	donor_gain	0.7100
11:5967561:T:TA	donor_gain	0.6900
11:5967721:CAGGA:C	acceptor_gain	0.6900
11:5967723:GGA:G	acceptor_gain	0.6600
11:5967724:GA:G	acceptor_gain	0.6500
11:5967722:AGGA:A	acceptor_gain	0.5900
11:5967895:G:C	donor_gain	0.5800
11:5968226:A:T	donor_gain	0.5800
11:5967728:G:C	acceptor_gain	0.5700
11:5967802:AAT:A	donor_gain	0.5700
11:5967728:G:GC	acceptor_gain	0.5600
11:5968120:G:C	donor_gain	0.5600
11:5968155:C:CA	donor_gain	0.5500
11:5968230:A:T	donor_gain	0.5500
11:5967985:T:C	donor_gain	0.5400
11:5967557:A:AT	donor_gain	0.5200
11:5967723:GGACT:G	acceptor_loss	0.5200
11:5967724:GACTG:G	acceptor_loss	0.5200
11:5967726:CT:C	acceptor_loss	0.5200
11:5967727:T:A	acceptor_loss	0.5200
11:5967916:A:AC	donor_gain	0.5200
11:5967973:T:TA	donor_gain	0.5000
11:5968089:A:AC	donor_gain	0.5000

AlphaMissense

2048 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:5968450:G:C	F15L	0.950
11:5968450:G:T	F15L	0.950
11:5968452:A:G	F15L	0.950
11:5968390:G:C	S35R	0.927
11:5968390:G:T	S35R	0.927
11:5968392:T:G	S35R	0.927
11:5968168:A:C	S109R	0.924
11:5968168:A:T	S109R	0.924
11:5968170:T:G	S109R	0.924
11:5967733:G:C	F254L	0.904
11:5967733:G:T	F254L	0.904
11:5967735:A:G	F254L	0.904
11:5967876:A:G	W207R	0.886
11:5967876:A:T	W207R	0.886
11:5967736:G:C	F253L	0.882
11:5967736:G:T	F253L	0.882
11:5967738:A:G	F253L	0.882
11:5968451:A:C	F15C	0.880
11:5968180:G:C	F105L	0.875
11:5968180:G:T	F105L	0.875
11:5968182:A:G	F105L	0.875
11:5968192:G:C	F101L	0.874
11:5968192:G:T	F101L	0.874
11:5968194:A:G	F101L	0.874
11:5968266:A:G	C77R	0.873
11:5968195:G:C	C100W	0.863
11:5968030:A:C	N155K	0.862
11:5968030:A:T	N155K	0.862
11:5968438:A:C	C19W	0.862
11:5968435:G:C	F20L	0.858

dbSNP variants (sampled 300 via entrez): RS1000610464 (11:5967838 G>A,C,T), RS1000961430 (11:5967467 A>G), RS1001839470 (11:5968620 T>C,G), RS1003500856 (11:5969500 T>C), RS1003846448 (11:5969878 A>T), RS1004466328 (11:5967401 C>A,T), RS1005463370 (11:5968655 G>A), RS1006475172 (11:5969370 C>A,T), RS1007224206 (11:5967334 C>A), RS1008333961 (11:5970297 C>T), RS1008392908 (11:5968969 C>T), RS1010224263 (11:5969487 A>T), RS1011328788 (11:5968646 C>A), RS1014441514 (11:5967181 C>A,G), RS1016438045 (11:5969943 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases methylation	1
Tretinoin	increases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.