OR56B1

Summary

OR56B1 (olfactory receptor family 56 subfamily B member 1, HGNC:15245) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 56B1 (Q8NGI3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 387748 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• MANE Select transcript: NM_001005180

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15245
Approved symbol	OR56B1
Name	olfactory receptor family 56 subfamily B member 1
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181023
Ensembl biotype	protein_coding
Entrez	387748

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000317121

RefSeq mRNA: 1 — MANE Select: NM_001005180 NM_001005180

CCDS: CCDS31395

Canonical transcript exons

ENST00000317121 — 1 exons

Exon	Start	End
ENSE00001256577	5736448	5738523

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 94.02.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.02	gold quality
colonic epithelium	UBERON:0000397	48.21	gold quality
lymph node	UBERON:0000029	43.92	gold quality
vermiform appendix	UBERON:0001154	43.92	silver quality
calcaneal tendon	UBERON:0003701	42.64	gold quality
spleen	UBERON:0002106	41.22	silver quality
descending thoracic aorta	UBERON:0002345	39.31	silver quality
granulocyte	CL:0000094	38.90	gold quality
bone marrow cell	CL:0002092	38.46	gold quality
right uterine tube	UBERON:0001302	37.70	silver quality
bone marrow	UBERON:0002371	37.62	gold quality
sural nerve	UBERON:0015488	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
mucosa of transverse colon	UBERON:0004991	36.47	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
tibial nerve	UBERON:0001323	36.35	silver quality
skeletal muscle tissue	UBERON:0001134	36.01	gold quality
endocervix	UBERON:0000458	35.76	silver quality
hindlimb stylopod muscle	UBERON:0004252	35.59	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
gall bladder	UBERON:0002110	35.30	gold quality
muscle tissue	UBERON:0002385	35.20	gold quality
cortex of kidney	UBERON:0001225	34.46	gold quality
small intestine Peyer’s patch	UBERON:0003454	34.45	silver quality
small intestine	UBERON:0002108	34.26	silver quality
rectum	UBERON:0001052	33.68	gold quality
myometrium	UBERON:0001296	32.91	gold quality
lower esophagus muscularis layer	UBERON:0035833	32.42	gold quality
lower esophagus	UBERON:0013473	32.34	gold quality
mucosa of stomach	UBERON:0001199	32.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.96

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or56b1b	ENSMUSG00000060105
mus_musculus	Or56b1	ENSMUSG00000073923

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 56B1 — Q8NGI3 (reviewed: Q8NGI3)

Alternative names: Olfactory receptor OR11-65

All UniProt accessions (1): Q8NGI3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005180* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGI3-F1	83.55	0.43

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 106–198

Glycosylation sites (1): 12

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_RESPONSE_TO_LIPID, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, NFE2L2.V2, REACTOME_OLFACTORY_SIGNALING_PATHWAY, OSMAN_BLOOD_CHAD63_KH_AGE_18_50YO_HIGH_DOSE_SUBJECTS_24HR_UP

GO Biological Process (6): cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

130 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR56B1	FRMPD1	Q5SYB0	480
OR56B1	HEPHL1	Q6MZM0	447
OR56B1	ZNF664	Q8N3J9	447
OR56B1	TRERF1	Q96PN7	400
OR56B1	UBR3	Q6ZT12	395
OR56B1	ZFAT	Q9P243	358
OR56B1	KIF21A	Q7Z4S6	354
OR56B1	KIF21B	O75037	350
OR56B1	SMG7	Q92540	306
OR56B1	CTC1	Q2NKJ3	305
OR56B1	MIER1	Q8N108	277
OR56B1	CSMD3	Q7Z407	255
OR56B1	NISCH	Q9Y2I1	254
OR56B1	TFDP1	Q14186	247
OR56B1	PLXNA1	Q9UIW2	246

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, A6NMU1, B3DH96, O88628, P0C646, P0C7T3, Q5J3E5, Q5J3G9, Q5J3M9, Q5QD29, Q6IF63, Q6W049, Q8NGB9, Q8NGD3, Q8NGF0, Q8NGF1, Q8NGH6, Q8NGH7, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGJ4, Q8NGJ8, Q8NGJ9, Q8NGK5, Q8NGK6, Q8NGV6, Q8NH53, Q8NH55, Q8NH56, Q8NH60, Q8NH61, Q8NH63, Q8NH67, Q8NH76, Q8NHC6, Q8TCB6, Q8VBV9

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

287 predictions. Top by Δscore:

Variant	Effect	Δscore
11:5737300:A:AG	acceptor_gain	0.6600
11:5736827:C:G	donor_gain	0.6200
11:5737166:G:GT	donor_gain	0.6200
11:5736563:TCCAG:T	donor_loss	0.5900
11:5736564:CCAG:C	donor_loss	0.5900
11:5736565:CAG:C	donor_loss	0.5900
11:5736566:AG:A	donor_loss	0.5900
11:5736567:GG:G	donor_loss	0.5900
11:5736568:G:GG	donor_loss	0.5900
11:5737119:G:GT	donor_gain	0.5900
11:5736569:T:G	donor_loss	0.5800
11:5736719:T:G	donor_gain	0.5800
11:5737301:C:G	acceptor_gain	0.5600
11:5736572:C:CG	donor_gain	0.5400
11:5736720:G:GG	donor_gain	0.5400
11:5737017:A:AG	acceptor_gain	0.5300
11:5737018:G:GG	acceptor_gain	0.5300
11:5737094:TCAC:T	donor_gain	0.5300
11:5737310:TAGTG:T	acceptor_gain	0.5300
11:5737311:AGTGA:A	acceptor_gain	0.5300
11:5736749:T:TA	donor_gain	0.5200
11:5736750:A:AA	donor_gain	0.5200
11:5737171:GATC:G	donor_gain	0.5200
11:5737222:A:AG	acceptor_gain	0.5200
11:5737223:G:GG	acceptor_gain	0.5200
11:5736562:TTCCA:T	donor_loss	0.5100
11:5736637:GCAC:G	donor_gain	0.5100
11:5737308:TGTAG:T	acceptor_gain	0.5100
11:5737140:G:GG	donor_gain	0.5000
11:5737311:A:AG	acceptor_gain	0.5000

AlphaMissense

2113 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:5736577:T:C	F21L	0.959
11:5736579:C:A	F21L	0.959
11:5736579:C:G	F21L	0.959
11:5736578:T:C	F21S	0.903
11:5737177:A:C	S221R	0.882
11:5737179:T:A	S221R	0.882
11:5737179:T:G	S221R	0.882
11:5736835:T:C	F107L	0.868
11:5736837:T:A	F107L	0.868
11:5736837:T:G	F107L	0.868
11:5737168:A:C	S218R	0.851
11:5737170:T:A	S218R	0.851
11:5737170:T:G	S218R	0.851
11:5736578:T:G	F21C	0.850
11:5737086:C:A	N190K	0.849
11:5737086:C:G	N190K	0.849
11:5737040:G:C	R175P	0.834
11:5736892:T:C	C126R	0.832
11:5737094:T:A	V193D	0.825
11:5736832:T:A	C106S	0.822
11:5736833:G:C	C106S	0.822
11:5736843:G:C	Q109H	0.818
11:5736843:G:T	Q109H	0.818
11:5737072:T:C	C186R	0.818
11:5737294:T:C	F260L	0.817
11:5737296:T:A	F260L	0.817
11:5737296:T:G	F260L	0.817
11:5736757:G:C	G81R	0.814
11:5736834:C:G	C106W	0.814
11:5737078:T:A	C188S	0.810

dbSNP variants (sampled 300 via entrez): RS1000176316 (11:5738176 C>G), RS1000613958 (11:5734935 T>A,C), RS1000645328 (11:5735242 G>C), RS1000672625 (11:5737737 A>G), RS1001189680 (11:5737990 T>A,G), RS1001277516 (11:5737840 T>G), RS1001311741 (11:5738090 G>GTT), RS1005062001 (11:5737445 C>A,G), RS1005357014 (11:5734512 T>C), RS1005634102 (11:5738703 G>C), RS1005932198 (11:5738488 C>T), RS1006201629 (11:5738686 A>C,G), RS1007428281 (11:5738838 A>G), RS1007934862 (11:5734681 A>G), RS1008762657 (11:5736791 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
hydroxyhydroquinone	increases expression	1
CGP 52608	increases reaction, affects binding	1
Atrazine	increases expression	1
Benzo(a)pyrene	increases methylation	1
Tretinoin	increases expression	1
Aflatoxin B1	decreases methylation	1
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.