OR5B17

Summary

OR5B17 (olfactory receptor family 5 subfamily B member 17, HGNC:15267) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5B17 (Q8NGF7). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219965 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 70 total
• MANE Select transcript: NM_001005489

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15267
Approved symbol	OR5B17
Name	olfactory receptor family 5 subfamily B member 17
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000197786
Ensembl biotype	protein_coding
Entrez	219965

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000357377

RefSeq mRNA: 1 — MANE Select: NM_001005489 NM_001005489

CCDS: CCDS31548

Canonical transcript exons

ENST00000357377 — 1 exons

Exon	Start	End
ENSE00001412966	58358124	58359069

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 85.20.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.20	gold quality
colonic epithelium	UBERON:0000397	41.98	gold quality
granulocyte	CL:0000094	38.09	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.54	gold quality
liver	UBERON:0002107	29.23	gold quality
monocyte	CL:0000576	29.07	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.89	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.34	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
right lobe of liver	UBERON:0001114	25.45	gold quality
muscle of leg	UBERON:0001383	25.02	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.63

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Or5b17	ENSRNOG00000043313

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5B17 — Q8NGF7 (reviewed: Q8NGF7)

Alternative names: Olfactory receptor 5B20, Olfactory receptor OR11-237

All UniProt accessions (2): A0A126GVL8, Q8NGF7

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005489* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGF7-F1	84.87	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

110 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5B17	TINAG	Q9UJW2	435
OR5B17	HTR4	Q13639	433
OR5B17	PCDH15	Q96QU1	308
OR5B17	USH2A	O75445	294
OR5B17	TAS2R60	P59551	290
OR5B17	LIPG	Q9Y5X9	276
OR5B17	RTP1	P59025	244
OR5B17	TYR	P14679	231
OR5B17	LAMC3	Q9Y6N6	222
OR5B17	ALPK3	Q96L96	214
OR5B17	XIRP1	Q702N8	213
OR5B17	CYP4F2	P78329	212
OR5B17	APOB	P04114	210
OR5B17	EHD3	Q9NZN3	206
OR5B17	DYNC2H1	Q8NCM8	203

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NDH6, A6NDL8, A6NET4, A6NHG9, A6NKK0, A6NMS3, P0DN80, P23268, P34982, P35898, Q60887, Q60892, Q7TRF3, Q7TS48, Q8NG80, Q8NG85, Q8NGA0, Q8NGE2, Q8NGF7, Q8NGI8, Q8NGL4, Q8NGS5, Q8NGU1, Q8NGU2, Q8NGV6, Q8NGV7, Q8NGY2, Q8NGY6, Q8NGY9, Q8NH16, Q8NH92, Q8NHB7, Q8NHB8, Q8NHC5, Q8NHC6, Q8NHC7, Q8VEX5, Q8VEX6, Q8VF13, Q8VFB9

Diamond homologs: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NL26, A6NM76, O76001, O76002, O76100, O95007, P0C623, P0C626, P23266, P23267, P23272, P23274, P30953, P30955, P34985, P58173, P59922, P70526, Q13606, Q5TZ20, Q60882, Q60890, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N146, Q8N148, Q8N162, Q8N628, Q8NGA1, Q8NGC5, Q8NGE1, Q8NGE2, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

70 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	61
Likely benign	9
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

184 predictions. Top by Δscore:

Variant	Effect	Δscore
11:58358318:A:C	acceptor_gain	0.9000
11:58358316:T:C	acceptor_gain	0.8700
11:58358320:A:C	acceptor_gain	0.8700
11:58358316:T:TC	acceptor_gain	0.8600
11:58358318:A:AC	acceptor_gain	0.7900
11:58358313:CAGT:C	acceptor_gain	0.7000
11:58358314:A:T	acceptor_gain	0.6500
11:58359051:CCT:C	donor_gain	0.6200
11:58359049:CACC:C	donor_loss	0.6100
11:58359050:A:AC	donor_gain	0.6100
11:58359051:C:CC	donor_gain	0.6100
11:58358303:A:C	acceptor_gain	0.6000
11:58358880:GGTTA:G	acceptor_gain	0.5900
11:58359051:CCTCT:C	donor_gain	0.5800
11:58358432:A:T	acceptor_gain	0.5700
11:58359050:AC:A	donor_gain	0.5400
11:58359050:ACCT:A	donor_gain	0.5400
11:58359051:CC:C	donor_gain	0.5400
11:58359051:CCTC:C	donor_gain	0.5400
11:58358315:G:GC	acceptor_gain	0.5300
11:58359048:TCACC:T	donor_gain	0.5300
11:58359049:CACCT:C	donor_gain	0.5300
11:58358309:A:AC	acceptor_gain	0.5100
11:58358567:A:C	acceptor_gain	0.5000
11:58359050:ACCTC:A	donor_gain	0.5000
11:58358492:CTA:C	donor_gain	0.4900
11:58359045:CACT:C	donor_gain	0.4900
11:58359046:ACTC:A	donor_gain	0.4900
11:58358885:C:CC	acceptor_gain	0.4800
11:58358445:G:GC	acceptor_gain	0.4700

AlphaMissense

2074 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:58359040:G:C	F10L	0.877
11:58359040:G:T	F10L	0.877
11:58359042:A:G	F10L	0.877
11:58358584:A:C	F162L	0.744
11:58358584:A:T	F162L	0.744
11:58358586:A:G	F162L	0.744
11:58358572:G:C	F166L	0.737
11:58358572:G:T	F166L	0.737
11:58358574:A:G	F166L	0.737
11:58358545:A:C	F175L	0.710
11:58358545:A:T	F175L	0.710
11:58358547:A:G	F175L	0.710
11:58358542:G:C	F176L	0.694
11:58358542:G:T	F176L	0.694
11:58358544:A:G	F176L	0.694
11:58358755:A:C	F105L	0.644
11:58358755:A:T	F105L	0.644
11:58358757:A:G	F105L	0.644
11:58358770:G:C	F100L	0.636
11:58358770:G:T	F100L	0.636
11:58358772:A:G	F100L	0.636
11:58359041:A:G	F10S	0.636
11:58358983:A:C	F29L	0.616
11:58358983:A:T	F29L	0.616
11:58358985:A:G	F29L	0.616
11:58358893:A:C	F59L	0.608
11:58358893:A:T	F59L	0.608
11:58358895:A:G	F59L	0.608
11:58358776:C:A	Q98H	0.577
11:58358776:C:G	Q98H	0.577

dbSNP variants (sampled 300 via entrez): RS1001948197 (11:58358014 A>C,T), RS1003898044 (11:58357919 G>C), RS1003961128 (11:58360723 C>T), RS1006349028 (11:58359791 G>A,C), RS1006708598 (11:58359371 T>A,C), RS1006881327 (11:58359776 C>A), RS1008587611 (11:58360622 C>T), RS1009266678 (11:58357935 T>A), RS1010815799 (11:58360462 T>C), RS1012223173 (11:58359839 G>T), RS1012602442 (11:58361040 C>T), RS1014239601 (11:58359928 G>T), RS1014499767 (11:58359565 G>A,C), RS1015040637 (11:58359068 A>G), RS1016304283 (11:58359407 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST006919_4	Ability to confide in someone	9.000000e-08
GCST006923_2	Loneliness	3.000000e-06
GCST006924_11	Loneliness (MTAG)	8.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009592	social interaction measurement
EFO:0007865	loneliness measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
didecyldimethylammonium	decreases expression	1
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.