OR5B2

Summary

OR5B2 (olfactory receptor family 5 subfamily B member 2, HGNC:8323) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5B2 (Q96R09). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390190 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 48 total
• MANE Select transcript: NM_001005566

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8323
Approved symbol	OR5B2
Name	olfactory receptor family 5 subfamily B member 2
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	OST073
Ensembl gene	ENSG00000172365
Ensembl biotype	protein_coding
Entrez	390190

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000302581, ENST00000641342

RefSeq mRNA: 1 — MANE Select: NM_001005566 NM_001005566

CCDS: CCDS31550

Canonical transcript exons

ENST00000641342 — 3 exons

Exon	Start	End
ENSE00003811658	58421238	58423289
ENSE00003812672	58428019	58428121
ENSE00003813496	58426622	58426676

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 41.18.

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	41.18	silver quality
adrenal tissue	UBERON:0018303	38.26	gold quality
granulocyte	CL:0000094	37.29	gold quality
calcaneal tendon	UBERON:0003701	37.25	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
endometrium	UBERON:0001295	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
mucosa of transverse colon	UBERON:0004991	36.15	gold quality
superior frontal gyrus	UBERON:0002661	35.89	gold quality
right coronary artery	UBERON:0001625	35.61	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.55	gold quality
descending thoracic aorta	UBERON:0002345	35.50	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
apex of heart	UBERON:0002098	35.15	gold quality
sural nerve	UBERON:0015488	35.04	gold quality
skeletal muscle tissue	UBERON:0001134	34.97	gold quality
blood	UBERON:0000178	34.50	gold quality
liver	UBERON:0002107	34.28	gold quality
bone marrow	UBERON:0002371	34.03	gold quality
right uterine tube	UBERON:0001302	34.01	gold quality
leukocyte	CL:0000738	33.95	gold quality
monocyte	CL:0000576	33.94	gold quality
corpus callosum	UBERON:0002336	33.67	gold quality
muscle tissue	UBERON:0002385	33.36	gold quality
tibial artery	UBERON:0007610	32.93	gold quality
popliteal artery	UBERON:0002250	32.88	gold quality
spleen	UBERON:0002106	32.58	gold quality
lymph node	UBERON:0000029	32.57	gold quality
cerebellar hemisphere	UBERON:0002245	32.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.62

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5b99	ENSMUSG00000046913
rattus_norvegicus	Or5b99	ENSRNOG00000087903

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 5B2 — Q96R09 (reviewed: Q96R09)

Alternative names: OST073, Olfactory receptor OR11-240

All UniProt accessions (1): Q96R09

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005566* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96R09-F1	90.06	0.70

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr11q12

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

56 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5B2	NPEPL1	Q8NDH3	582
OR5B2	XYLB	O75191	475
OR5B2	LAMA1	P25391	311
OR5B2	PHYHIP	Q92561	307
OR5B2	TOMM40	O96008	292
OR5B2	THOC7	Q6I9Y2	272
OR5B2	APOC1	P02654	272
OR5B2	CYP24A1	Q07973	270
OR5B2	MED8	Q96G25	247
OR5B2	PLAUR	Q03405	166
OR5B2	TNP2	Q05952	162
OR5B2	GNAL	P38405	109
OR5B2	GNAS	Q5JWF2	109
OR5B2	OSCAR	Q8IYS5	102
OR5B2	GNG8	Q9UK08	80

IntAct

0 interactions, top by confidence:

BioGRID (1): OR5B2 (Affinity Capture-MS)

ESM2 similar proteins: A6NL26, O14581, O76100, O95006, P34986, P37068, P37070, P37071, P58173, Q5TZ20, Q60890, Q60893, Q6IEU7, Q8N146, Q8NGA1, Q8NGE9, Q8NGG1, Q8NGG4, Q8NGI9, Q8NGL2, Q8NGP8, Q8NGQ1, Q8NGQ6, Q8NGS0, Q8NGZ4, Q8NGZ9, Q8NH01, Q8NH04, Q8NHC8, Q8VEW5, Q8VEZ0, Q8VF65, Q8VF66, Q8VF76, Q8VFD2, Q8VFL9, Q8VFM9, Q8VFX2, Q8VG02, Q8VG05

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

171 predictions. Top by Δscore:

Variant	Effect	Δscore
11:58422850:CA:C	donor_gain	0.9900
11:58423245:T:TA	donor_gain	0.9600
11:58422849:A:AC	donor_gain	0.9000
11:58422850:C:CC	donor_gain	0.9000
11:58422823:ATGAG:A	donor_gain	0.8700
11:58422993:A:AC	donor_gain	0.8400
11:58422842:G:C	donor_gain	0.8300
11:58422995:G:T	donor_gain	0.8300
11:58423025:G:T	donor_gain	0.8300
11:58422631:C:CC	acceptor_gain	0.8200
11:58422892:CTG:C	donor_gain	0.8100
11:58423024:TG:T	donor_gain	0.8100
11:58423092:A:C	donor_gain	0.8000
11:58423070:CAGG:C	donor_gain	0.7800
11:58423023:A:AC	donor_gain	0.7700
11:58423087:A:AC	donor_gain	0.7500
11:58422628:TAA:T	acceptor_gain	0.7300
11:58422891:A:AC	donor_gain	0.7300
11:58422892:C:CC	donor_gain	0.7300
11:58422855:G:A	donor_gain	0.7000
11:58422937:C:CT	donor_gain	0.6900
11:58423076:A:AC	donor_gain	0.6900
11:58423077:C:CC	donor_gain	0.6900
11:58423246:C:A	donor_gain	0.6900
11:58422626:GATAA:G	acceptor_gain	0.6700
11:58423060:C:CT	donor_gain	0.6500
11:58422840:CAG:C	donor_gain	0.6300
11:58422938:C:CT	donor_gain	0.6200
11:58423218:AGT:A	donor_gain	0.6200
11:58422994:TG:T	donor_gain	0.6000

AlphaMissense

2050 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:58423232:G:C	F10L	0.923
11:58423232:G:T	F10L	0.923
11:58423234:A:G	F10L	0.923
11:58422737:A:C	F175L	0.869
11:58422737:A:T	F175L	0.869
11:58422739:A:G	F175L	0.869
11:58422734:G:C	F176L	0.824
11:58422734:G:T	F176L	0.824
11:58422736:A:G	F176L	0.824
11:58422764:G:C	F166L	0.821
11:58422764:G:T	F166L	0.821
11:58422766:A:G	F166L	0.821
11:58423233:A:G	F10S	0.798
11:58422776:G:C	F162L	0.764
11:58422776:G:T	F162L	0.764
11:58422778:A:G	F162L	0.764
11:58422515:G:C	F249L	0.751
11:58422515:G:T	F249L	0.751
11:58422517:A:G	F249L	0.751
11:58422437:G:C	F275L	0.731
11:58422437:G:T	F275L	0.731
11:58422439:A:G	F275L	0.731
11:58422968:C:A	Q98H	0.729
11:58422968:C:G	Q98H	0.729
11:58422962:G:C	F100L	0.724
11:58422962:G:T	F100L	0.724
11:58422964:A:G	F100L	0.724
11:58422956:A:C	F102L	0.719
11:58422956:A:T	F102L	0.719
11:58422958:A:G	F102L	0.719

dbSNP variants (sampled 300 via entrez): RS1000103913 (11:58428917 C>A), RS1000137295 (11:58423501 G>A), RS1000199245 (11:58426768 T>C), RS1000547240 (11:58429402 A>G), RS1000578893 (11:58428581 A>G), RS1001168008 (11:58422191 A>G), RS1001383577 (11:58428041 A>G), RS1001617765 (11:58422782 G>A), RS1001770955 (11:58429185 C>A,T), RS1001800431 (11:58429355 G>A), RS1002843008 (11:58420766 T>C), RS1003173166 (11:58421016 A>C,G), RS1003440779 (11:58427799 T>A,C), RS1003473982 (11:58428099 G>T), RS1003747635 (11:58425645 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004133_47	Ulcerative colitis	9.000000e-06
GCST006919_4	Ability to confide in someone	9.000000e-08
GCST006923_2	Loneliness	3.000000e-06
GCST006924_11	Loneliness (MTAG)	8.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009592	social interaction measurement
EFO:0007865	loneliness measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
theaflavin-3,3’-digallate	affects expression	1
Benzo(a)pyrene	increases methylation	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.