OR5BS1

Summary

OR5BS1 (olfactory receptor family 5 subfamily BS member 1, HGNC:19627) is a protein-coding gene on chromosome 12q13.11, encoding Olfactory receptor 5BS1 (A0A2R8YED5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390313 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001396061

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19627
Approved symbol	OR5BS1
Name	olfactory receptor family 5 subfamily BS member 1
Location	12q13.11
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000198678
Ensembl biotype	protein_coding
Entrez	390313

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000328207

RefSeq mRNA: 1 — MANE Select: NM_001396061 NM_001396061

CCDS: CCDS91691

Canonical transcript exons

ENST00000328207 — 2 exons

Exon	Start	End
ENSE00001211776	48562794	48562956
ENSE00001322607	48559882	48560654

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 65.08.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.08	gold quality
sural nerve	UBERON:0015488	38.45	gold quality
bone marrow cell	CL:0002092	38.19	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.78	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
lymph node	UBERON:0000029	27.57	gold quality
superior frontal gyrus	UBERON:0002661	27.37	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.98	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.11	gold quality
leukocyte	CL:0000738	26.08	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
monocyte	CL:0000576	25.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
calcaneal tendon	UBERON:0003701	25.06	gold quality
muscle of leg	UBERON:0001383	24.93	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.47

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5bs2	ENSMUSG00000108728
rattus_norvegicus	Or5bs2	ENSRNOG00000062462

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 5BS1 — A0A2R8YED5 (reviewed: A0A2R8YED5)

Alternative names: Olfactory receptor family 5 subfamily BS member 1

All UniProt accessions (1): A0A2R8YED5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001382990* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050516	Olfactory_GPCR	Family

Pfam: PF13853

UniProt features (17 total): topological domain 8, transmembrane region 7, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A2R8YED5-F1	89.10	0.62

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, IRX2_TARGET_GENES, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr12q13

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

40 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5BS1	PCP4L1	A6NKN8	403
OR5BS1	CNGA2	Q16280	381
OR5BS1	ANO2	Q9NQ90	380
OR5BS1	GNAL	P38405	363
OR5BS1	S100A5	P33763	322
OR5BS1	ADCY3	O60266	263
OR5BS1	OR51C1	A0A3B3IT45	209
OR5BS1	ADCY8	P40145	203
OR5BS1	PTPRN	Q16849	196
OR5BS1	SERPINA5	P05154	179
OR5BS1	PLAUR	Q03405	166
OR5BS1	TNP2	Q05952	162
OR5BS1	GNAS	Q5JWF2	109
OR5BS1	OSCAR	Q8IYS5	102
OR5BS1	GNG8	Q9UK08	80

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2001 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:48559915:T:C	F12L	0.928
12:48559917:T:A	F12L	0.928
12:48559917:T:G	F12L	0.928
12:48560383:T:C	F168L	0.918
12:48560385:C:A	F168L	0.918
12:48560385:C:G	F168L	0.918
12:48560410:T:C	F177L	0.916
12:48560412:T:A	F177L	0.916
12:48560412:T:G	F177L	0.916
12:48562849:A:C	S277R	0.869
12:48562851:T:A	S277R	0.869
12:48562851:T:G	S277R	0.869
12:48560248:T:C	F123L	0.860
12:48560250:T:A	F123L	0.860
12:48560250:T:G	F123L	0.860
12:48559963:T:C	F28L	0.853
12:48559965:T:A	F28L	0.853
12:48559965:T:G	F28L	0.853
12:48559972:T:C	F31L	0.852
12:48559974:C:A	F31L	0.852
12:48559974:C:G	F31L	0.852
12:48560632:T:C	F251L	0.839
12:48560634:T:A	F251L	0.839
12:48560634:T:G	F251L	0.839
12:48562885:A:C	S289R	0.829
12:48562887:T:A	S289R	0.829
12:48562887:T:G	S289R	0.829
12:48560384:T:G	F168C	0.821
12:48559916:T:C	F12S	0.817
12:48560235:G:A	M118I	0.806

dbSNP variants (sampled 300 via entrez): RS1000112705 (12:48562675 A>G), RS1000330076 (12:48560780 T>C), RS1001165372 (12:48562433 A>C,G), RS1001217553 (12:48562587 T>C), RS1002221970 (12:48561380 C>T), RS1002762666 (12:48558899 T>C), RS1002877288 (12:48558453 A>G), RS1003771211 (12:48560485 A>G), RS1003846265 (12:48563248 C>T), RS1004667155 (12:48559036 G>A), RS1004719596 (12:48559287 A>AAAAAG), RS1005181526 (12:48558200 C>A,T), RS1005343081 (12:48561806 C>T), RS1005394732 (12:48562094 C>T), RS1005778263 (12:48559738 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Endosulfan	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.