OR5D14

Summary

OR5D14 (olfactory receptor family 5 subfamily D member 14, HGNC:15281) is a protein-coding gene on chromosome 11q11, encoding Olfactory receptor 5D14 (Q8NGL3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219436 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 50 total
• MANE Select transcript: NM_001004735

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15281
Approved symbol	OR5D14
Name	olfactory receptor family 5 subfamily D member 14
Location	11q11
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000186113
Ensembl biotype	protein_coding
Entrez	219436

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000335605

RefSeq mRNA: 1 — MANE Select: NM_001004735 NM_001004735

CCDS: CCDS31508

Canonical transcript exons

ENST00000335605 — 1 exons

Exon	Start	End
ENSE00001335953	55795556	55796500

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 80.57.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.57	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.67	gold quality
duodenum	UBERON:0002114	28.14	gold quality
monocyte	CL:0000576	27.58	gold quality
leukocyte	CL:0000738	27.58	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.18	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.01	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.15	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
right lobe of liver	UBERON:0001114	23.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5d36	ENSMUSG00000075137
mus_musculus	Or5d14	ENSMUSG00000075139
rattus_norvegicus	Or5d14l1	ENSRNOG00000068411
rattus_norvegicus	Or5d14	ENSRNOG00000082203

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5D14 — Q8NGL3 (reviewed: Q8NGL3)

Alternative names: Olfactory receptor OR11-141, Olfactory receptor OR11-150

All UniProt accessions (1): Q8NGL3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004735* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGL3-F1	89.16	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 7, 169

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, BOSCO_TH1_CYTOTOXIC_MODULE, ZWANG_EGF_PERSISTENTLY_DN, chr11q11

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

240 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5D14	DCUN1D2	Q6PH85	478
OR5D14	TRIM48	Q8IWZ4	447
OR5D14	TRIM51	Q9BSJ1	433
OR5D14	ZNF57	Q68EA5	396
OR5D14	PGLYRP4	Q96LB8	370
OR5D14	SASH3	O75995	351
OR5D14	ZNF737	O75373	324
OR5D14	XPO7	Q9UIA9	318
OR5D14	KRTAP9-1	A8MXZ3	311
OR5D14	GABRE	P78334	305
OR5D14	MAGEH1	Q9H213	305
OR5D14	ZBTB18	Q99592	277
OR5D14	GDI1	P31150	274
OR5D14	CFAP47	Q6ZTR5	261
OR5D14	KRTAP9-2	Q9BYQ4	256

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NM76, P37067, P37069, P37070, P37071, P58181, Q13606, Q60884, Q60886, Q60895, Q8N127, Q8N162, Q8NGE1, Q8NGE2, Q8NGF7, Q8NGG4, Q8NGL1, Q8NGL3, Q8NGS4, Q8NGS5, Q8NGS9, Q8NGT0, Q8NH48, Q8NH51, Q8NH92, Q8NH93, Q8VEW5, Q8VEW6, Q8VF12, Q8VF66, Q8VFD0, Q8VFD1, Q8VFD3, Q8VFK2

Diamond homologs: A6NL26, O95221, P0C617, P0C626, P0C7N1, P0C7N5, P0DMU2, P37070, Q13606, Q15617, Q60880, Q60884, Q60886, Q60893, Q60895, Q6IEU7, Q8N0Y5, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NG78, Q8NGC0, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2, Q8NGG3, Q8NGG4, Q8NGG5, Q8NGG7, Q8NGI9, Q8NGJ0, Q8NGK9, Q8NGL0, Q8NGL1, Q8NGL2, Q8NGL3, Q8NGM9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

50 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	48
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

311 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55796399:GTT:G	acceptor_gain	0.8000
11:55795676:GTG:G	donor_gain	0.7900
11:55796236:A:AG	acceptor_gain	0.7300
11:55796399:GTTGT:G	acceptor_gain	0.7300
11:55796398:A:AG	acceptor_gain	0.7200
11:55796399:G:GG	acceptor_gain	0.7200
11:55795573:GAATC:G	donor_gain	0.6800
11:55795909:A:AG	acceptor_gain	0.6700
11:55795910:G:GG	acceptor_gain	0.6700
11:55796229:T:TA	acceptor_gain	0.6700
11:55796227:T:TA	acceptor_gain	0.6600
11:55796097:G:GG	donor_gain	0.6500
11:55795675:AGT:A	donor_gain	0.6300
11:55796399:GT:G	acceptor_gain	0.6300
11:55795609:TTTC:T	donor_gain	0.6100
11:55795663:G:GG	donor_gain	0.6100
11:55795673:ACAGT:A	donor_gain	0.6100
11:55796318:G:A	acceptor_gain	0.6100
11:55795787:A:AG	acceptor_gain	0.6000
11:55795788:T:G	acceptor_gain	0.5900
11:55796255:A:AG	acceptor_gain	0.5700
11:55796256:G:GG	acceptor_gain	0.5700
11:55796395:CACA:C	acceptor_loss	0.5600
11:55796396:ACAG:A	acceptor_loss	0.5600
11:55796397:CAGTT:C	acceptor_loss	0.5600
11:55796399:G:GT	acceptor_loss	0.5600
11:55795565:GTTT:G	donor_gain	0.5500
11:55795566:TTTT:T	donor_gain	0.5500
11:55796397:C:G	acceptor_gain	0.5500
11:55795820:A:AG	donor_gain	0.5400

AlphaMissense

2083 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55795595:T:C	F14L	0.805
11:55795597:T:A	F14L	0.805
11:55795597:T:G	F14L	0.805
11:55795610:T:C	F19L	0.777
11:55795612:C:A	F19L	0.777
11:55795612:C:G	F19L	0.777
11:55795652:T:C	F33L	0.772
11:55795654:T:A	F33L	0.772
11:55795654:T:G	F33L	0.772
11:55796090:T:C	F179L	0.758
11:55796092:C:A	F179L	0.758
11:55796092:C:G	F179L	0.758
11:55796063:T:C	F170L	0.756
11:55796065:C:A	F170L	0.756
11:55796065:C:G	F170L	0.756
11:55796312:T:C	F253L	0.709
11:55796314:C:A	F253L	0.709
11:55796314:C:G	F253L	0.709
11:55795928:T:C	F125L	0.707
11:55795930:T:A	F125L	0.707
11:55795930:T:G	F125L	0.707
11:55795801:G:C	K82N	0.667
11:55795801:G:T	K82N	0.667
11:55795643:T:C	F30L	0.665
11:55795645:C:A	F30L	0.665
11:55795645:C:G	F30L	0.665
11:55796390:T:C	F279L	0.603
11:55796392:T:A	F279L	0.603
11:55796392:T:G	F279L	0.603
11:55796273:T:C	F240L	0.598

dbSNP variants (sampled 300 via entrez): RS1001134314 (11:55796142 T>C), RS1003151241 (11:55796911 G>A), RS1004290380 (11:55796712 C>A,T), RS1007085068 (11:55795038 C>A), RS1007410885 (11:55793743 G>A,C), RS1007456407 (11:55794801 C>T), RS1010838253 (11:55794399 C>A), RS1011030967 (11:55796959 C>T), RS1014356605 (11:55793994 G>T), RS1018519986 (11:55794422 C>T), RS1018552921 (11:55794852 G>A,T), RS1019596168 (11:55796997 T>C), RS1020220876 (11:55795453 C>G), RS1022425693 (11:55796975 C>A), RS1022589415 (11:55793998 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-palmitoylglycerol	increases expression	1
Acetaminophen	increases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.