OR5D16

Summary

OR5D16 (olfactory receptor family 5 subfamily D member 16, HGNC:15283) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5D16 (Q8NGK9). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390144 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 65 total
• MANE Select transcript: NM_001005496

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15283
Approved symbol	OR5D16
Name	olfactory receptor family 5 subfamily D member 16
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000205029
Ensembl biotype	protein_coding
Entrez	390144

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000378396

RefSeq mRNA: 1 — MANE Select: NM_001005496 NM_001005496

CCDS: CCDS31512

Canonical transcript exons

ENST00000378396 — 1 exons

Exon	Start	End
ENSE00001477316	55838752	55839738

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.70.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	37.70	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.23	gold quality
prefrontal cortex	UBERON:0000451	29.22	gold quality
monocyte	CL:0000576	28.73	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.37	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	25.02	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.35	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
frontal cortex	UBERON:0001870	24.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.98

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5d16	ENSMUSG00000075145

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5D16 — Q8NGK9 (reviewed: Q8NGK9)

Alternative names: Olfactory receptor OR11-154

All UniProt accessions (1): Q8NGK9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005496* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGK9-F1	84.07	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 7

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

242 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5D16	TRIM64B	A6NI03	599
OR5D16	TRIM48	Q8IWZ4	469
OR5D16	TRIM51	Q9BSJ1	446
OR5D16	ZNF737	O75373	348
OR5D16	CFAP47	Q6ZTR5	270
OR5D16	POTEM	A6NI47	268
OR5D16	VWA3B	Q502W6	250
OR5D16	MRPL19	P49406	223
OR5D16	TM4SF20	Q53R12	220
OR5D16	OR52E6	Q96RD3	213
OR5D16	KIF25	Q9UIL4	208
OR5D16	NPIPA5	E9PKD4	207
OR5D16	FRMD1	Q8N878	203
OR5D16	OR52I2	Q8NH67	203
OR5D16	ZNF277	Q9NRM2	203
OR5D16	NPIPA3	F8WFD2	203

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NDH6, A6NDL8, A6NET4, A6NHG9, A6NKK0, A6NMS3, P0C617, P0DN80, P23268, P34983, P35896, P35898, P37067, P37069, Q7TRF3, Q7TS48, Q8NG80, Q8NG85, Q8NGF7, Q8NGK9, Q8NGL4, Q8NGS5, Q8NGS6, Q8NGU1, Q8NGV6, Q8NGV7, Q8NGY2, Q8NGY6, Q8NGY9, Q8NH16, Q8NH90, Q8NH92, Q8NHB7, Q8NHB8, Q8NHC5, Q8NHC6, Q8VEW2, Q8VEX6, Q8VF12, Q8VF13

Diamond homologs: A6NL26, O95221, P0C617, P0C626, P0C7N1, P0C7N5, P0DMU2, P37070, Q13606, Q15617, Q60880, Q60884, Q60886, Q60893, Q60895, Q6IEU7, Q8N0Y5, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NG78, Q8NGC0, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2, Q8NGG3, Q8NGG4, Q8NGG5, Q8NGG7, Q8NGI9, Q8NGJ0, Q8NGK9, Q8NGL0, Q8NGL1, Q8NGL2, Q8NGL3, Q8NGM9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	60
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

278 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55838870:GTGTG:G	donor_gain	0.7700
11:55839104:C:CA	acceptor_gain	0.7700
11:55839411:T:TA	acceptor_gain	0.7000
11:55839414:A:AG	acceptor_gain	0.6400
11:55839415:T:G	acceptor_gain	0.6300
11:55839421:A:AG	acceptor_gain	0.6300
11:55839418:A:AG	acceptor_gain	0.6100
11:55839105:G:A	acceptor_gain	0.5900
11:55839419:T:G	acceptor_gain	0.5900
11:55839421:ATT:A	acceptor_gain	0.5800
11:55839423:T:TA	acceptor_gain	0.5800
11:55839253:T:G	donor_gain	0.5600
11:55838875:G:GG	donor_gain	0.5500
11:55839044:G:GT	donor_gain	0.5500
11:55839376:G:GC	acceptor_gain	0.5500
11:55839431:C:G	acceptor_gain	0.5500
11:55839422:T:G	acceptor_gain	0.5400
11:55839434:TGAAG:T	acceptor_gain	0.5400
11:55838821:G:GT	donor_gain	0.5300
11:55839437:A:AG	acceptor_gain	0.5300
11:55839438:G:GG	acceptor_gain	0.5300
11:55839014:T:TA	donor_gain	0.5200
11:55838871:TGTGG:T	donor_loss	0.5100
11:55838873:TGGTA:T	donor_loss	0.5100
11:55838874:GGTAG:G	donor_loss	0.5100
11:55838875:G:T	donor_loss	0.5100
11:55838876:T:A	donor_loss	0.5100
11:55839411:T:G	acceptor_gain	0.5100
11:55839435:GAAGA:G	acceptor_gain	0.5100
11:55838872:GTG:G	donor_gain	0.5000

AlphaMissense

2161 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55838806:T:C	F19L	0.782
11:55838808:C:A	F19L	0.782
11:55838808:C:G	F19L	0.782
11:55838791:T:C	F14L	0.777
11:55838793:C:A	F14L	0.777
11:55838793:C:G	F14L	0.777
11:55839286:T:C	F179L	0.732
11:55839288:C:A	F179L	0.732
11:55839288:C:G	F179L	0.732
11:55839259:T:C	F170L	0.695
11:55839261:T:A	F170L	0.695
11:55839261:T:G	F170L	0.695
11:55839124:T:C	F125L	0.677
11:55839126:T:A	F125L	0.677
11:55839126:T:G	F125L	0.677
11:55838848:T:C	F33L	0.656
11:55838850:T:A	F33L	0.656
11:55838850:T:G	F33L	0.656
11:55839058:T:C	F103L	0.626
11:55839060:C:A	F103L	0.626
11:55839060:C:G	F103L	0.626
11:55839382:A:C	S211R	0.618
11:55839384:C:A	S211R	0.618
11:55839384:C:G	S211R	0.618
11:55839508:T:C	F253L	0.614
11:55839510:C:A	F253L	0.614
11:55839510:C:G	F253L	0.614
11:55839586:T:C	F279L	0.603
11:55839588:T:A	F279L	0.603
11:55839588:T:G	F279L	0.603

dbSNP variants (sampled 300 via entrez): RS1000166586 (11:55839691 A>G), RS1001133544 (11:55837549 C>T), RS1001288259 (11:55837813 C>G), RS1002285349 (11:55836954 G>A), RS1002701655 (11:55837256 A>C), RS1002905364 (11:55840200 G>A,C), RS1004218524 (11:55839368 C>A,T), RS1004409487 (11:55839065 T>A,C), RS1005942540 (11:55838462 T>A,C), RS1006347345 (11:55840079 C>A,T), RS1007544681 (11:55837884 A>G,T), RS1008281268 (11:55838176 G>C,T), RS1011180522 (11:55838752 A>C,G), RS1011534759 (11:55838062 A>C), RS1011783628 (11:55840039 C>A,G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST006103_10	Interleukin-6 levels	6.000000e-06
GCST008839_600	Height	2.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004810	interleukin-6 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases methylation	1
2-palmitoylglycerol	increases expression	1
Benzo(a)pyrene	affects methylation	1
Hydrogen Peroxide	increases expression	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.