OR5D18

Summary

OR5D18 (olfactory receptor family 5 subfamily D member 18, HGNC:15285) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5D18 (Q8NGL1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219438 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 56 total
• MANE Select transcript: NM_001001952

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15285
Approved symbol	OR5D18
Name	olfactory receptor family 5 subfamily D member 18
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000186119
Ensembl biotype	protein_coding
Entrez	219438

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000333976

RefSeq mRNA: 1 — MANE Select: NM_001001952 NM_001001952

CCDS: CCDS31510

Canonical transcript exons

ENST00000333976 — 1 exons

Exon	Start	End
ENSE00001786896	55819630	55820571

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 87.15.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.15	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	54.94	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
monocyte	CL:0000576	29.88	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.68	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.69	gold quality
duodenum	UBERON:0002114	28.14	gold quality
primary visual cortex	UBERON:0002436	27.77	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.20	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.17	gold quality
calcaneal tendon	UBERON:0003701	25.03	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5d35	ENSMUSG00000045150
mus_musculus	Or5d18	ENSMUSG00000075140
mus_musculus	Or5d47	ENSMUSG00000075142
rattus_norvegicus	Or5d35	ENSRNOG00000063734
rattus_norvegicus	Or5d18	ENSRNOG00000067924
rattus_norvegicus	Or5d47	ENSRNOG00000068434

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5D18 — Q8NGL1 (reviewed: Q8NGL1)

Alternative names: Olfactory receptor OR11-143, Olfactory receptor OR11-152

All UniProt accessions (1): Q8NGL1

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001952* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGL1-F1	88.38	0.62

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 7

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 33 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GSE17721_CTRL_VS_CPG_0.5H_BMDC_DN, GSE17721_POLYIC_VS_CPG_0.5H_BMDC_UP, GSE17721_LPS_VS_CPG_0.5H_BMDC_DN, GSE17721_POLYIC_VS_GARDIQUIMOD_4H_BMDC_UP

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

330 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5D18	ZNF99	A8MXY4	398
OR5D18	TRIM48	Q8IWZ4	391
OR5D18	TRIM51	Q9BSJ1	370
OR5D18	LRRC55	Q6ZSA7	348
OR5D18	LRFN5	Q96NI6	275
OR5D18	ZNF737	O75373	270
OR5D18	ADAM29	Q9UKF5	263
OR5D18	SEMG1	P04279	249
OR5D18	OSBPL3	Q9H4L5	248
OR5D18	PSG8	Q9UQ74	244
OR5D18	ANO2	Q9NQ90	241
OR5D18	GABRA6	Q16445	226
OR5D18	ACER2	Q5QJU3	224
OR5D18	KEL	P23276	223
OR5D18	RTP1	P59025	222

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NM76, P37067, P37069, P37070, P37071, P58181, Q13606, Q60884, Q60886, Q60895, Q8N127, Q8N162, Q8NGE1, Q8NGE2, Q8NGF7, Q8NGG4, Q8NGL1, Q8NGL3, Q8NGS4, Q8NGS5, Q8NGS9, Q8NGT0, Q8NH48, Q8NH51, Q8NH92, Q8NH93, Q8VEW5, Q8VEW6, Q8VF12, Q8VF66, Q8VFD0, Q8VFD1, Q8VFD3, Q8VFK2

Diamond homologs: A6NDH6, A6NET4, A6NHG9, A6NKK0, A6NL26, A6NMS3, O95221, P0C626, P0C628, P0C7N1, P0C7N5, P0DMU2, P0DN80, P34983, P37070, P37071, P37072, Q13606, Q15617, Q15620, Q60880, Q60882, Q60884, Q60886, Q60893, Q60894, Q60895, Q6IEU7, Q6IF36, Q6UXT6, Q7TR96, Q7TS48, Q8N127, Q8N162, Q8NG75, Q8NG78, Q8NGC0, Q8NGE7, Q8NGF4, Q8NGF7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

329 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55820471:T:TA	acceptor_gain	0.8100
11:55820388:T:TA	acceptor_gain	0.7200
11:55820467:ACCGT:A	acceptor_gain	0.7200
11:55820503:A:AG	acceptor_gain	0.7200
11:55820504:G:GG	acceptor_gain	0.7200
11:55819925:T:TA	donor_gain	0.6900
11:55819926:A:AA	donor_gain	0.6900
11:55820495:T:TA	acceptor_gain	0.6400
11:55820202:T:TA	acceptor_gain	0.6300
11:55820410:T:A	acceptor_gain	0.6300
11:55820286:T:TA	acceptor_gain	0.6200
11:55820466:C:G	acceptor_gain	0.6200
11:55819919:GA:G	donor_gain	0.6000
11:55820128:T:G	donor_gain	0.6000
11:55820212:A:AG	acceptor_gain	0.5900
11:55820387:AT:A	acceptor_gain	0.5900
11:55820467:A:AG	acceptor_gain	0.5900
11:55819702:C:T	donor_gain	0.5800
11:55819955:T:TA	acceptor_gain	0.5800
11:55820168:G:GG	donor_gain	0.5700
11:55820301:A:AG	acceptor_gain	0.5700
11:55820248:AAT:A	acceptor_gain	0.5600
11:55820467:ACC:A	acceptor_gain	0.5600
11:55820248:A:AG	acceptor_gain	0.5500
11:55820288:C:CA	acceptor_gain	0.5400
11:55820311:AAGAT:A	acceptor_gain	0.5400
11:55820465:A:AG	acceptor_gain	0.5400
11:55819920:A:G	donor_gain	0.5300
11:55820312:A:G	acceptor_gain	0.5300
11:55820211:C:G	acceptor_gain	0.5200

AlphaMissense

2044 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55819681:T:C	F18L	0.798
11:55819683:C:A	F18L	0.798
11:55819683:C:G	F18L	0.798
11:55820161:T:C	F178L	0.793
11:55820163:C:A	F178L	0.793
11:55820163:C:G	F178L	0.793
11:55820257:A:C	S210R	0.790
11:55820259:C:A	S210R	0.790
11:55820259:C:G	S210R	0.790
11:55819666:T:C	F13L	0.789
11:55819668:C:A	F13L	0.789
11:55819668:C:G	F13L	0.789
11:55820503:A:C	S292R	0.767
11:55820505:T:A	S292R	0.767
11:55820505:T:G	S292R	0.767
11:55820344:T:C	F239L	0.758
11:55820346:C:A	F239L	0.758
11:55820346:C:G	F239L	0.758
11:55819723:T:C	F32L	0.754
11:55819725:T:A	F32L	0.754
11:55819725:T:G	F32L	0.754
11:55819999:T:C	F124L	0.752
11:55820001:C:A	F124L	0.752
11:55820001:C:G	F124L	0.752
11:55820134:T:C	F169L	0.737
11:55820136:T:A	F169L	0.737
11:55820136:T:G	F169L	0.737
11:55820461:T:C	F278L	0.732
11:55820463:T:A	F278L	0.732
11:55820463:T:G	F278L	0.732

dbSNP variants (sampled 300 via entrez): RS1002532607 (11:55817909 C>G), RS1002706253 (11:55818185 C>G,T), RS1004489444 (11:55819600 C>G), RS1005778270 (11:55818922 G>T), RS1006121952 (11:55819233 A>C,T), RS1006150911 (11:55817877 T>C), RS1006192881 (11:55818538 A>G), RS1006714566 (11:55820475 G>A), RS1007197883 (11:55820233 T>C,G), RS1007673945 (11:55817677 A>G), RS1007784740 (11:55817961 C>T), RS1011775480 (11:55818961 G>A,C,T), RS1012228454 (11:55818859 C>G), RS1012882283 (11:55818599 C>T), RS1014773678 (11:55819354 C>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases expression	2
hydroxyhydroquinone	increases expression	1
methylparaben	increases expression	1
CGP 52608	affects binding, increases reaction	1
Valproic Acid	decreases methylation	1
Permethrin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.