OR5D3

Summary

OR5D3 (olfactory receptor family 5 subfamily D member 3, HGNC:8336) is a protein-coding gene on chromosome 11q11, encoding Olfactory receptor 5D3 (A0A2R8Y4L6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 8594 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001396059

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8336
Approved symbol	OR5D3
Name	olfactory receptor family 5 subfamily D member 3
Location	11q11
Locus type	gene with protein product
Status	Approved
Aliases	OR11-8b, OR11-8c
Ensembl gene	ENSG00000186886
Ensembl biotype	protein_coding
Entrez	8594

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641440

RefSeq mRNA: 1 — MANE Select: NM_001396059 NM_001396059

CCDS: CCDS91473

Canonical transcript exons

ENST00000641440 — 2 exons

Exon	Start	End
ENSE00003811491	55726216	55729621
ENSE00003813826	55723776	55724054

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.45

Regulation

Is transcription factor: no

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5d3	ENSMUSG00000075128
mus_musculus	Or5d44	ENSMUSG00000080713
mus_musculus	Or5d45	ENSMUSG00000083855
rattus_norvegicus		ENSRNOG00000066602
rattus_norvegicus	Or5d45	ENSRNOG00000067265
rattus_norvegicus	Olfr1177	ENSRNOG00000068113

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5D3 — A0A2R8Y4L6 (reviewed: A0A2R8Y4L6)

Alternative names: Olfactory receptor family 5 subfamily D member 3 pseudogene

All UniProt accessions (1): A0A2R8Y4L6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001382988* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (17 total): topological domain 8, transmembrane region 7, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

No AlphaFold model available for A0A2R8Y4L6 — AlphaFold DB does not currently provide models for proteins above ~3000 aa.

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 106–188

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr11q11

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

8 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5D3	HAUS3	Q68CZ6	73
OR5D3	GNAL	P38405	70
OR5D3	GNAS	Q5JWF2	70
OR5D3	OR6K2	Q8NGY2	0

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2142 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55727084:A:C	S300R	0.931
11:55727086:C:A	S300R	0.931
11:55727086:C:G	S300R	0.931
11:55726841:A:C	S219R	0.922
11:55726843:C:A	S219R	0.922
11:55726843:C:G	S219R	0.922
11:55726667:A:C	S161R	0.895
11:55726669:T:A	S161R	0.895
11:55726669:T:G	S161R	0.895
11:55726715:T:C	F177L	0.891
11:55726717:T:A	F177L	0.891
11:55726717:T:G	F177L	0.891
11:55726838:A:C	S218R	0.882
11:55726840:C:A	S218R	0.882
11:55726840:C:G	S218R	0.882
11:55726262:T:C	F26L	0.878
11:55726264:C:A	F26L	0.878
11:55726264:C:G	F26L	0.878
11:55726947:T:C	L254P	0.874
11:55726964:T:C	F260L	0.874
11:55726966:C:A	F260L	0.874
11:55726966:C:G	F260L	0.874
11:55726742:T:C	F186L	0.870
11:55726744:T:A	F186L	0.870
11:55726744:T:G	F186L	0.870
11:55727092:G:C	R302S	0.861
11:55727092:G:T	R302S	0.861
11:55726247:T:C	F21L	0.859
11:55726249:C:A	F21L	0.859
11:55726249:C:G	F21L	0.859

dbSNP variants (sampled 300 via entrez): RS1000151511 (11:55728959 G>A), RS1000232176 (11:55728803 A>C), RS1002175491 (11:55729668 G>A,T), RS1002303698 (11:55724902 T>C), RS1002567950 (11:55722577 A>G), RS1002586795 (11:55727602 A>G), RS1002906524 (11:55729885 A>G,T), RS1005522847 (11:55723068 A>G), RS1005815344 (11:55723255 G>A,T), RS1006134234 (11:55722552 A>T), RS1006142568 (11:55722383 C>T), RS1006367488 (11:55727204 G>A,C,T), RS1006630291 (11:55729405 A>G), RS1006684297 (11:55729188 A>G), RS1008878300 (11:55725284 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Ivermectin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.