OR5F1

Summary

OR5F1 (olfactory receptor family 5 subfamily F member 1, HGNC:8343) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5F1 (O95221). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 338674 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 42 total
• MANE Select transcript: NM_003697

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8343
Approved symbol	OR5F1
Name	olfactory receptor family 5 subfamily F member 1
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	OR11-10
Ensembl gene	ENSG00000149133
Ensembl biotype	protein_coding
OMIM	608492
Entrez	338674

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000278409

RefSeq mRNA: 1 — MANE Select: NM_003697 NM_003697

CCDS: CCDS31515

Canonical transcript exons

ENST00000278409 — 1 exons

Exon	Start	End
ENSE00000988940	55993681	55994625

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
lymph node	UBERON:0000029	27.57	gold quality
leukocyte	CL:0000738	27.31	gold quality
monocyte	CL:0000576	27.28	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.81	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
blood	UBERON:0000178	25.94	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.81	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
pancreas	UBERON:0001264	24.02	gold quality
frontal cortex	UBERON:0001870	24.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5be3	ENSMUSG00000075165
mus_musculus	Or13a23	ENSMUSG00000110092
rattus_norvegicus	Or5be3	ENSRNOG00000034047

Paralogs (96): OR5C1 (ENSG00000148215), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 5F1 — O95221 (reviewed: O95221)

Alternative names: Olfactory receptor 11-10, Olfactory receptor OR11-167

All UniProt accessions (1): O95221

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_003688* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95221-F1	89.04	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, IRF5_TARGET_GENES, WP_GPCRS_CLASS_A_RHODOPSINLIKE, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): sensory perception of smell (GO:0007608), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

150 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5F1	FAM47C	Q5HY64	515
OR5F1	TRIM48	Q8IWZ4	476
OR5F1	TRIM51	Q9BSJ1	447
OR5F1	ZNF737	O75373	349
OR5F1	CSNK1G1	Q9HCP0	348
OR5F1	TRIP4	Q15650	325
OR5F1	Q6GMV1	Q6GMV1	311
OR5F1	LRRC7	Q96NW7	307
OR5F1	CFAP47	Q6ZTR5	277
OR5F1	POTEM	A6NI47	272
OR5F1	ADGRL2	O95490	265
OR5F1	VWA3B	Q502W6	260
OR5F1	USP3	Q9Y6I4	247
OR5F1	BCORL1	Q5H9F3	245
OR5F1	SNX1	Q13596	228

IntAct

4 interactions, top by confidence:

A	B	Type	Score
OR5F1	UBA6	psi-mi:“MI:0914”(association)	0.530
SCRIB	OR5F1	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (22): CCDC25 (Affinity Capture-MS), NME2P1 (Affinity Capture-MS), UBE2D2 (Affinity Capture-MS), UBA6 (Affinity Capture-MS), GALM (Affinity Capture-MS), WDR44 (Affinity Capture-MS), HMGCS1 (Affinity Capture-MS), HMGCS1 (Affinity Capture-MS), NME2P1 (Affinity Capture-MS), UBA6 (Affinity Capture-MS), FTO (Affinity Capture-MS), CCDC25 (Affinity Capture-MS), IRGQ (Affinity Capture-MS), GNPNAT1 (Affinity Capture-MS), GALM (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NCV1, O95221, P0C7N1, P0C7N5, Q60881, Q60888, Q6IEU7, Q8NGA8, Q8NGB6, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD4, Q8NGD5, Q8NGE8, Q8NGF8, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGM9, Q8NGP8, Q8NGP9, Q8NGS9, Q8NGT0, Q8NH01, Q8NH10, Q8NH18, Q8NH21, Q8NH41, Q8NH42, Q8NH43, Q8NH49, Q8NH69, Q8NH85, Q8VEW5, Q8VF65, Q8VFD3

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

42 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

260 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55993935:CCGAA:C	acceptor_gain	0.8600
11:55993936:CGAA:C	acceptor_gain	0.7600
11:55993969:G:C	donor_gain	0.7100
11:55994033:ATG:A	donor_gain	0.6800
11:55993870:A:C	acceptor_gain	0.6700
11:55993968:A:AC	donor_gain	0.6700
11:55993942:CA:C	acceptor_gain	0.6100
11:55993943:A:C	acceptor_gain	0.6100
11:55993939:A:AC	acceptor_gain	0.6000
11:55993859:A:C	acceptor_gain	0.5800
11:55993939:A:C	acceptor_gain	0.5800
11:55993739:T:A	donor_gain	0.5700
11:55993786:CACTG:C	acceptor_gain	0.5700
11:55993788:C:CC	acceptor_gain	0.5700
11:55993845:TCAG:T	acceptor_gain	0.5700
11:55993754:C:CC	acceptor_gain	0.5600
11:55993786:CAC:C	donor_gain	0.5600
11:55993936:C:T	acceptor_gain	0.5600
11:55994033:A:AC	donor_gain	0.5600
11:55994255:GCATA:G	donor_loss	0.5600
11:55994256:CATA:C	donor_loss	0.5600
11:55994257:ATACC:A	donor_loss	0.5600
11:55994258:TACCT:T	donor_loss	0.5600
11:55994259:ACCT:A	donor_loss	0.5600
11:55994260:C:CG	donor_loss	0.5600
11:55993869:CA:C	acceptor_gain	0.5500
11:55994034:T:C	donor_gain	0.5500
11:55994043:T:A	donor_gain	0.5500
11:55993849:G:C	acceptor_gain	0.5400
11:55994450:A:C	donor_gain	0.5400

AlphaMissense

2058 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55994590:G:C	F12L	0.916
11:55994590:G:T	F12L	0.916
11:55994592:A:G	F12L	0.916
11:55994122:G:C	F168L	0.845
11:55994122:G:T	F168L	0.845
11:55994124:A:G	F168L	0.845
11:55994095:G:C	F177L	0.791
11:55994095:G:T	F177L	0.791
11:55994097:A:G	F177L	0.791
11:55994272:C:A	M118I	0.788
11:55994272:C:G	M118I	0.788
11:55994272:C:T	M118I	0.788
11:55994092:G:C	F178L	0.737
11:55994092:G:T	F178L	0.737
11:55994094:A:G	F178L	0.737
11:55994542:A:C	F28L	0.735
11:55994542:A:T	F28L	0.735
11:55994544:A:G	F28L	0.735
11:55994179:A:C	F149L	0.700
11:55994179:A:T	F149L	0.700
11:55994181:A:G	F149L	0.700
11:55994591:A:C	F12C	0.678
11:55993873:G:C	F251L	0.675
11:55993873:G:T	F251L	0.675
11:55993875:A:G	F251L	0.675
11:55994344:A:C	F94L	0.658
11:55994344:A:T	F94L	0.658
11:55994346:A:G	F94L	0.658
11:55994443:G:C	F61L	0.650
11:55994443:G:T	F61L	0.650

dbSNP variants (sampled 300 via entrez): RS1000084850 (11:55994473 G>A,T), RS1002155086 (11:55994998 G>A), RS1002208725 (11:55994809 T>A), RS1004541080 (11:55994799 G>A), RS1005836403 (11:55996178 G>C), RS1007450115 (11:55995669 T>C), RS1008020050 (11:55993224 C>T), RS1008317617 (11:55995106 T>C), RS1009344369 (11:55994079 G>T), RS1009478754 (11:55994259 A>G), RS1011817430 (11:55995312 C>G), RS1012821517 (11:55996250 G>A,C), RS1013694935 (11:55995116 A>C), RS1014057443 (11:55995341 G>A), RS1014728080 (11:55995441 T>A,C)

Disease associations

OMIM: gene MIM:608492 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-palmitoylglycerol	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.