OR5H14

Summary

OR5H14 (olfactory receptor family 5 subfamily H member 14, HGNC:31286) is a protein-coding gene on chromosome 3q11.2, encoding Olfactory receptor 5H14 (A6NHG9). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 403273 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 65 total
• MANE Select transcript: NM_001005514

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31286
Approved symbol	OR5H14
Name	olfactory receptor family 5 subfamily H member 14
Location	3q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000236032
Ensembl biotype	protein_coding
Entrez	403273

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000437310, ENST00000641380

RefSeq mRNA: 1 — MANE Select: NM_001005514 NM_001005514

CCDS: CCDS33798

Canonical transcript exons

ENST00000641380 — 2 exons

Exon	Start	End
ENSE00003812800	98147479	98147554
ENSE00003813954	98149368	98156614

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 44.60.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	44.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	41.66	gold quality
sural nerve	UBERON:0015488	39.52	gold quality
ganglionic eminence	UBERON:0004023	38.79	gold quality
monocyte	CL:0000576	38.21	gold quality
leukocyte	CL:0000738	37.73	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
bone marrow	UBERON:0002371	37.14	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
apex of heart	UBERON:0002098	34.97	gold quality
blood	UBERON:0000178	34.95	gold quality
skeletal muscle tissue	UBERON:0001134	34.75	gold quality
muscle tissue	UBERON:0002385	34.19	gold quality
granulocyte	CL:0000094	34.14	gold quality
calcaneal tendon	UBERON:0003701	33.40	gold quality
liver	UBERON:0002107	33.24	gold quality
myometrium	UBERON:0001296	32.43	gold quality
mucosa of stomach	UBERON:0001199	32.16	gold quality
ectocervix	UBERON:0012249	32.12	gold quality
descending thoracic aorta	UBERON:0002345	32.08	gold quality
superior frontal gyrus	UBERON:0002661	31.98	gold quality
uterine cervix	UBERON:0000002	31.88	gold quality
popliteal artery	UBERON:0002250	31.81	gold quality
left coronary artery	UBERON:0001626	31.77	gold quality
tibial artery	UBERON:0007610	31.77	gold quality
heart left ventricle	UBERON:0002084	31.43	gold quality
urinary bladder	UBERON:0001255	31.32	gold quality
cerebellum	UBERON:0002037	31.17	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.41
E-GEOD-83139	no	3.00

Regulation

Is transcription factor: no

Cross-species orthologs

20 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5h19	ENSMUSG00000043357
mus_musculus	Or5h18	ENSMUSG00000047960
mus_musculus	Or5h25	ENSMUSG00000060057
mus_musculus	Or5h17	ENSMUSG00000062105
mus_musculus	Or5h22	ENSMUSG00000064006
mus_musculus	Or5h23	ENSMUSG00000094539
mus_musculus	Or5h26	ENSMUSG00000096695
rattus_norvegicus	Or5h18	ENSRNOG00000066195
rattus_norvegicus	Or5h25b	ENSRNOG00000071849
rattus_norvegicus	Or5h25	ENSRNOG00000073369
rattus_norvegicus	Or5h17b	ENSRNOG00000073471
rattus_norvegicus	Or5h25d	ENSRNOG00000073651
rattus_norvegicus	Or5h27b	ENSRNOG00000075854
rattus_norvegicus	Or5h26b	ENSRNOG00000077075
rattus_norvegicus		ENSRNOG00000077444
rattus_norvegicus	Or5h24b	ENSRNOG00000079937
rattus_norvegicus	Or5h17c	ENSRNOG00000084393
rattus_norvegicus	Or5h26	ENSRNOG00000085701
rattus_norvegicus	Or5h17	ENSRNOG00000087735
rattus_norvegicus	Or5h24	ENSRNOG00000090523

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5H14 — A6NHG9 (reviewed: A6NHG9)

All UniProt accessions (1): A6NHG9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005514* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NHG9-F1	89.37	0.70

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr3q11

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

150 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5H14	ZNF562	Q6V9R5	506
OR5H14	DEFB113	Q30KQ7	475
OR5H14	C5orf63	A6NC05	448
OR5H14	INTS14	Q96SY0	448
OR5H14	SPAG11A	Q6PDA7	445
OR5H14	SWSAP1	Q6NVH7	431
OR5H14	ERI2	A8K979	419
OR5H14	ZNF611	Q8N823	419
OR5H14	RSAD1	Q9HA92	418
OR5H14	ZNF713	Q8N859	414
OR5H14	E7EVR1	E7EVR1	394
OR5H14	ZNF92	Q03936	370
OR5H14	TANGO2	Q6ICL3	370
OR5H14	M9MMK7	M9MMK7	367
OR5H14	PIGZ	Q86VD9	367

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NDH6, A6NDL8, A6NET4, A6NHG9, A6NKK0, A6NMS3, P0DN80, P23268, P34982, P35898, Q60887, Q60892, Q7TRF3, Q7TS48, Q8NG80, Q8NG85, Q8NGA0, Q8NGE2, Q8NGF7, Q8NGI8, Q8NGL4, Q8NGS5, Q8NGU1, Q8NGU2, Q8NGV6, Q8NGV7, Q8NGY2, Q8NGY6, Q8NGY9, Q8NH16, Q8NH92, Q8NHB7, Q8NHB8, Q8NHC5, Q8NHC6, Q8NHC7, Q8VEX5, Q8VEX6, Q8VF13, Q8VFB9

Diamond homologs: A6NDH6, A6NET4, A6NHG9, A6NKK0, A6NL26, A6NMS3, O95221, P0C626, P0C628, P0C7N1, P0C7N5, P0DMU2, P0DN80, P34985, P37068, P37070, P37071, P37072, Q13606, Q15617, Q15620, Q60880, Q60882, Q60884, Q60886, Q60893, Q60894, Q6UXT6, Q7TS48, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NG78, Q8NGC0, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	62
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

224 predictions. Top by Δscore:

Variant	Effect	Δscore
3:98149645:C:G	donor_gain	0.9800
3:98149649:GA:G	donor_gain	0.9800
3:98149536:A:T	donor_gain	0.9700
3:98149651:G:GG	donor_gain	0.9700
3:98149561:T:G	donor_gain	0.9000
3:98149839:G:GA	donor_gain	0.8700
3:98149566:T:G	donor_gain	0.8100
3:98149838:T:TA	donor_gain	0.8100
3:98149833:G:GG	donor_gain	0.7900
3:98149416:GA:G	donor_gain	0.7700
3:98149680:A:G	donor_gain	0.7300
3:98149432:G:GT	donor_gain	0.7200
3:98149993:CA:C	acceptor_loss	0.7100
3:98149994:A:AC	acceptor_loss	0.7100
3:98149986:A:AG	acceptor_gain	0.6900
3:98149418:G:GG	donor_gain	0.6700
3:98149417:A:AG	donor_gain	0.6600
3:98149455:A:T	donor_gain	0.6400
3:98149995:GGTTC:G	acceptor_gain	0.6200
3:98149995:GGTT:G	acceptor_gain	0.6100
3:98149648:AGA:A	donor_gain	0.5900
3:98149649:GAG:G	donor_gain	0.5900
3:98149987:T:G	acceptor_gain	0.5800
3:98149832:T:G	donor_gain	0.5500
3:98149840:G:GG	donor_gain	0.5500
3:98150041:T:G	acceptor_gain	0.5500
3:98149650:AGT:A	donor_loss	0.5400
3:98149651:GT:G	donor_loss	0.5400
3:98149420:T:A	donor_gain	0.5300
3:98149652:TAA:T	donor_loss	0.5300

AlphaMissense

2030 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:98149887:T:C	F168L	0.834
3:98149889:C:A	F168L	0.834
3:98149889:C:G	F168L	0.834
3:98149419:T:C	F12L	0.784
3:98149421:T:A	F12L	0.784
3:98149421:T:G	F12L	0.784
3:98149914:T:C	F177L	0.751
3:98149916:T:A	F177L	0.751
3:98149916:T:G	F177L	0.751
3:98150256:A:C	S291R	0.749
3:98150258:C:A	S291R	0.749
3:98150258:C:G	S291R	0.749
3:98149750:G:C	R122P	0.731
3:98149722:T:C	F113L	0.725
3:98149724:T:A	F113L	0.725
3:98149724:T:G	F113L	0.725
3:98149476:T:C	F31L	0.715
3:98149478:C:A	F31L	0.715
3:98149478:C:G	F31L	0.715
3:98150243:T:A	N286K	0.706
3:98150243:T:G	N286K	0.706
3:98149739:G:A	M118I	0.701
3:98149739:G:C	M118I	0.701
3:98149739:G:T	M118I	0.701
3:98149741:C:A	A119E	0.688
3:98150264:A:C	R293S	0.683
3:98150264:A:T	R293S	0.683
3:98149762:T:A	I126K	0.674
3:98149704:A:C	S107R	0.663
3:98149706:T:A	S107R	0.663

dbSNP variants (sampled 300 via entrez): RS1000387265 (3:98150268 A>C,G), RS1001202291 (3:98154149 G>T), RS1001283593 (3:98154337 A>G), RS1001401268 (3:98153070 G>A,C), RS1003034914 (3:98147095 C>A), RS1003044745 (3:98146704 G>A,T), RS1003963013 (3:98154292 G>A), RS1005577302 (3:98150468 A>T), RS1005666352 (3:98152911 C>T), RS1005761733 (3:98148347 CTT>C,CT), RS1005963098 (3:98147185 G>C), RS1006000085 (3:98154118 T>G), RS1006040246 (3:98153138 C>A,T), RS1006249652 (3:98148596 C>A,T), RS1006325084 (3:98147467 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005039_1	Uncontrolled blood pressure in combination therapy (beta blocker and thiazide diuretic)	4.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007766	response to beta blocker

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	decreases expression, affects cotreatment	2
sodium arsenite	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Copper	affects cotreatment, decreases expression	1
Plant Extracts	decreases expression, affects cotreatment	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.