OR5H15

Summary

OR5H15 (olfactory receptor family 5 subfamily H member 15, HGNC:31287) is a protein-coding gene on chromosome 3q11.2, encoding Olfactory receptor 5H15 (A6NDH6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 403274 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 72 total
• MANE Select transcript: NM_001005515

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31287
Approved symbol	OR5H15
Name	olfactory receptor family 5 subfamily H member 15
Location	3q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000233412
Ensembl biotype	protein_coding
Entrez	403274

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641450

RefSeq mRNA: 1 — MANE Select: NM_001005515 NM_001005515

CCDS: CCDS33799

Canonical transcript exons

ENST00000641450 — 2 exons

Exon	Start	End
ENSE00003812778	98168682	98169774
ENSE00003813832	98166696	98166831

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 38.31.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	38.31	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
skeletal muscle tissue	UBERON:0001134	35.64	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
muscle tissue	UBERON:0002385	32.72	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.84	gold quality
monocyte	CL:0000576	29.38	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
lymph node	UBERON:0000029	28.90	gold quality
liver	UBERON:0002107	28.34	gold quality
duodenum	UBERON:0002114	28.14	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.70	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.14	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.40	gold quality
calcaneal tendon	UBERON:0003701	25.29	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Cross-species orthologs

20 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5h19	ENSMUSG00000043357
mus_musculus	Or5h18	ENSMUSG00000047960
mus_musculus	Or5h25	ENSMUSG00000060057
mus_musculus	Or5h17	ENSMUSG00000062105
mus_musculus	Or5h22	ENSMUSG00000064006
mus_musculus	Or5h23	ENSMUSG00000094539
mus_musculus	Or5h26	ENSMUSG00000096695
rattus_norvegicus	Or5h18	ENSRNOG00000066195
rattus_norvegicus	Or5h25b	ENSRNOG00000071849
rattus_norvegicus	Or5h25	ENSRNOG00000073369
rattus_norvegicus	Or5h17b	ENSRNOG00000073471
rattus_norvegicus	Or5h25d	ENSRNOG00000073651
rattus_norvegicus	Or5h27b	ENSRNOG00000075854
rattus_norvegicus	Or5h26b	ENSRNOG00000077075
rattus_norvegicus		ENSRNOG00000077444
rattus_norvegicus	Or5h24b	ENSRNOG00000079937
rattus_norvegicus	Or5h17c	ENSRNOG00000084393
rattus_norvegicus	Or5h26	ENSRNOG00000085701
rattus_norvegicus	Or5h17	ENSRNOG00000087735
rattus_norvegicus	Or5h24	ENSRNOG00000090523

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5H15 — A6NDH6 (reviewed: A6NDH6)

All UniProt accessions (1): A6NDH6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005515* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NDH6-F1	88.96	0.70

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_B, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

84 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5H15	RTP1	P59025	407
OR5H15	TAS2R60	P59551	339
OR5H15	BAG6	P46379	311
OR5H15	RIC8B	Q9NVN3	235
OR5H15	OR14K1	Q8NGZ2	213
OR5H15	OR2T3	Q8NH03	145
OR5H15	OR2G2	Q8NGZ5	140
OR5H15	OR2T34	Q8NGX1	139
OR5H15	OR14A16	Q8NHC5	139
OR5H15	OR4K17	Q8NGC6	126
OR5H15	OR1L3	Q8NH93	125
OR5H15	OR2B3	O76000	120
OR5H15	OR5B17	Q8NGF7	98
OR5H15	FAM187B	Q17R55	91
OR5H15	HAUS3	Q68CZ6	73

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NDH6, A6NDL8, A6NET4, A6NHG9, A6NKK0, A6NMS3, P0DN80, P23268, P34982, P35898, Q60887, Q60892, Q7TRF3, Q7TS48, Q8NG80, Q8NG85, Q8NGA0, Q8NGE2, Q8NGF7, Q8NGI8, Q8NGL4, Q8NGS5, Q8NGU1, Q8NGU2, Q8NGV6, Q8NGV7, Q8NGY2, Q8NGY6, Q8NGY9, Q8NH16, Q8NH92, Q8NHB7, Q8NHB8, Q8NHC5, Q8NHC6, Q8NHC7, Q8VEX5, Q8VEX6, Q8VF13, Q8VFB9

Diamond homologs: A6NDH6, A6NET4, A6NHG9, A6NKK0, A6NL26, A6NMS3, O95221, P0C626, P0C628, P0C7N1, P0C7N5, P0DMU2, P0DN80, P34985, P37068, P37070, P37071, P37072, Q13606, Q15617, Q15620, Q60880, Q60882, Q60884, Q60886, Q60893, Q60894, Q6UXT6, Q7TS48, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NG78, Q8NGC0, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	62
Likely benign	10
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

135 predictions. Top by Δscore:

Variant	Effect	Δscore
3:98168963:GA:G	donor_gain	0.9900
3:98168959:C:G	donor_gain	0.9800
3:98168965:G:GG	donor_gain	0.9800
3:98168850:A:T	donor_gain	0.9600
3:98168875:T:G	donor_gain	0.9300
3:98169585:C:T	donor_gain	0.9300
3:98168880:T:G	donor_gain	0.8800
3:98168769:A:T	donor_gain	0.7900
3:98168730:GA:G	donor_gain	0.7700
3:98169395:GGGT:G	donor_gain	0.7600
3:98169396:GGTG:G	donor_gain	0.7600
3:98168746:G:GT	donor_gain	0.7400
3:98169583:A:AG	donor_gain	0.7300
3:98169584:G:GG	donor_gain	0.7300
3:98168962:AGA:A	donor_gain	0.7200
3:98168963:GAG:G	donor_gain	0.7200
3:98168994:A:G	donor_gain	0.6800
3:98169517:TG:T	donor_gain	0.6800
3:98169518:GG:G	donor_gain	0.6800
3:98168732:G:GG	donor_gain	0.6600
3:98168796:G:GG	donor_gain	0.6600
3:98168731:A:AG	donor_gain	0.6400
3:98169337:C:G	donor_gain	0.6400
3:98169405:A:T	donor_gain	0.6300
3:98169580:A:G	donor_gain	0.6200
3:98169580:A:AG	donor_gain	0.6100
3:98168791:TCTTG:T	donor_loss	0.5700
3:98168792:CTTG:C	donor_loss	0.5700
3:98168793:TTG:T	donor_loss	0.5700
3:98168794:TG:T	donor_loss	0.5700

AlphaMissense

2046 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:98169201:T:C	F168L	0.899
3:98169203:C:A	F168L	0.899
3:98169203:C:G	F168L	0.899
3:98169327:A:C	S210R	0.895
3:98169329:C:A	S210R	0.895
3:98169329:C:G	S210R	0.895
3:98169064:G:C	R122P	0.870
3:98169570:A:C	S291R	0.850
3:98169572:T:A	S291R	0.850
3:98169572:T:G	S291R	0.850
3:98168733:T:C	F12L	0.840
3:98168735:T:A	F12L	0.840
3:98168735:T:G	F12L	0.840
3:98169055:C:A	A119E	0.808
3:98169061:A:C	D121A	0.800
3:98169578:A:C	R293S	0.799
3:98169578:A:T	R293S	0.799
3:98169062:T:A	D121E	0.795
3:98169062:T:G	D121E	0.795
3:98169053:G:A	M118I	0.789
3:98169053:G:C	M118I	0.789
3:98169053:G:T	M118I	0.789
3:98169444:T:C	C249R	0.788
3:98169557:T:A	N286K	0.784
3:98169557:T:G	N286K	0.784
3:98168790:T:C	F31L	0.771
3:98168792:C:A	F31L	0.771
3:98168792:C:G	F31L	0.771
3:98169072:G:C	A125P	0.757
3:98169076:T:A	I126K	0.754

dbSNP variants (sampled 300 via entrez): RS1000076710 (3:98164749 T>C), RS1000184884 (3:98168247 A>C), RS1000502827 (3:98167022 G>A,C), RS1000833378 (3:98165305 C>A,G), RS1001787557 (3:98168121 T>C), RS1001828284 (3:98167213 C>A,T), RS1002180719 (3:98165889 T>C), RS1002554309 (3:98166148 C>A,T), RS1002794055 (3:98167077 T>G), RS1002869345 (3:98167208 T>C), RS1003201264 (3:98168325 A>G), RS1003823821 (3:98165168 G>A), RS1004607962 (3:98170129 C>A), RS1004661003 (3:98167338 C>T), RS1004952788 (3:98169743 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.