OR5H8

Summary

OR5H8 (olfactory receptor family 5 subfamily H member 8 (gene/pseudogene), HGNC:14773) is a protein-coding gene on chromosome 3q11.2, encoding Olfactory receptor 5H8 (P0DN80). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional.

Source: NCBI Gene 79289 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14773
Approved symbol	OR5H8
Name	olfactory receptor family 5 subfamily H member 8 (gene/pseudogene)
Location	3q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000232535
Ensembl biotype	protein_coding
Entrez	79289

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding_LoF

ENST00000394191

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000394191 — 2 exons

Exon	Start	End
ENSE00001594636	98311886	98312843
ENSE00003811654	98306752	98306838

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 86.81.

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.81	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
apex of heart	UBERON:0002098	37.14	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.12	gold quality
duodenum	UBERON:0002114	33.52	silver quality
muscle tissue	UBERON:0002385	32.34	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.48	gold quality
leukocyte	CL:0000738	29.31	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
lymph node	UBERON:0000029	29.02	silver quality
fundus of stomach	UBERON:0001160	28.10	silver quality
liver	UBERON:0002107	28.04	gold quality
placenta	UBERON:0001987	27.85	gold quality
pancreas	UBERON:0001264	27.44	gold quality
tonsil	UBERON:0002372	27.05	gold quality
body of pancreas	UBERON:0001150	26.99	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
prostate gland	UBERON:0002367	26.18	silver quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ENAD-17	no	140.23
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Cross-species orthologs

20 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5h19	ENSMUSG00000043357
mus_musculus	Or5h18	ENSMUSG00000047960
mus_musculus	Or5h25	ENSMUSG00000060057
mus_musculus	Or5h17	ENSMUSG00000062105
mus_musculus	Or5h22	ENSMUSG00000064006
mus_musculus	Or5h23	ENSMUSG00000094539
mus_musculus	Or5h26	ENSMUSG00000096695
rattus_norvegicus	Or5h18	ENSRNOG00000066195
rattus_norvegicus	Or5h25b	ENSRNOG00000071849
rattus_norvegicus	Or5h25	ENSRNOG00000073369
rattus_norvegicus	Or5h17b	ENSRNOG00000073471
rattus_norvegicus	Or5h25d	ENSRNOG00000073651
rattus_norvegicus	Or5h27b	ENSRNOG00000075854
rattus_norvegicus	Or5h26b	ENSRNOG00000077075
rattus_norvegicus		ENSRNOG00000077444
rattus_norvegicus	Or5h24b	ENSRNOG00000079937
rattus_norvegicus	Or5h17c	ENSRNOG00000084393
rattus_norvegicus	Or5h26	ENSRNOG00000085701
rattus_norvegicus	Or5h17	ENSRNOG00000087735
rattus_norvegicus	Or5h24	ENSRNOG00000090523

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5H8 — P0DN80 (reviewed: P0DN80)

Alternative names: Olfactory receptor 5H8 pseudogene, Olfactory receptor OR3-7

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Polymorphism. Segregating pseudogene, locus showing both intact and pseudogene forms in the population. A single nucleotide deletion at position Lys-229 in the gene coding for this protein is responsible for functional diversity, producing a pseudogene.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (17 total): topological domain 8, transmembrane region 7, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DN80-F1	90.04	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 14 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr3q11, GOBP_NERVOUS_SYSTEM_PROCESS

GO Biological Process (0):

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (1): plasma membrane (GO:0005886)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

3 interactions, top by confidence:

A	B	Type	Score
OR5H8	NIFK	psi-mi:“MI:0915”(physical association)	0.400
OR5H8	CCDC68	psi-mi:“MI:0915”(physical association)	0.400

ESM2 similar proteins: A6NDH6, A6NDL8, A6NET4, A6NHG9, A6NKK0, A6NMS3, P0DN80, P23268, P34982, P35898, Q60887, Q60892, Q7TRF3, Q7TS48, Q8NG80, Q8NG85, Q8NGA0, Q8NGE2, Q8NGF7, Q8NGI8, Q8NGL4, Q8NGS5, Q8NGU1, Q8NGU2, Q8NGV6, Q8NGV7, Q8NGY2, Q8NGY6, Q8NGY9, Q8NH16, Q8NH92, Q8NHB7, Q8NHB8, Q8NHC5, Q8NHC6, Q8NHC7, Q8VEX5, Q8VEX6, Q8VF13, Q8VFB9

Diamond homologs: A6NDH6, A6NET4, A6NHG9, A6NKK0, A6NL26, A6NMS3, O95221, P0C626, P0C628, P0C7N1, P0C7N5, P0DMU2, P0DN80, P34985, P37068, P37070, P37071, P37072, Q13606, Q15617, Q15620, Q60880, Q60882, Q60884, Q60886, Q60893, Q60894, Q6UXT6, Q7TS48, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NG78, Q8NGC0, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

199 predictions. Top by Δscore:

Variant	Effect	Δscore
3:98311943:GA:G	donor_gain	0.7000
3:98312004:TCTTG:T	donor_loss	0.6700
3:98312005:CTTG:C	donor_loss	0.6700
3:98312006:TTG:T	donor_loss	0.6700
3:98312007:TG:T	donor_loss	0.6700
3:98312008:GG:G	donor_loss	0.6700
3:98312009:G:GA	donor_loss	0.6700
3:98312010:T:G	donor_loss	0.6700
3:98311959:G:GT	donor_gain	0.6400
3:98311959:GACT:G	donor_loss	0.6400
3:98312011:A:C	donor_loss	0.6400
3:98312009:G:GG	donor_gain	0.6300
3:98312088:T:G	donor_gain	0.6200
3:98311945:G:GG	donor_gain	0.6100
3:98311944:A:AG	donor_gain	0.5900
3:98312584:A:AG	acceptor_gain	0.5900
3:98312093:T:G	donor_gain	0.5600
3:98312570:T:G	acceptor_gain	0.5400
3:98312665:ACTAT:A	acceptor_gain	0.5400
3:98311982:A:T	donor_gain	0.5300
3:98312176:GA:G	donor_gain	0.5300
3:98312690:T:G	acceptor_gain	0.5300
3:98311981:G:GT	donor_gain	0.5200
3:98312063:A:T	donor_gain	0.5200
3:98312172:C:G	donor_gain	0.5200
3:98312668:AT:A	acceptor_gain	0.5200
3:98312568:C:G	acceptor_gain	0.5100
3:98312686:T:G	acceptor_gain	0.5100
3:98312669:T:TA	acceptor_gain	0.5000
3:98312669:T:G	acceptor_gain	0.4900

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.