OR5L2

Summary

OR5L2 (olfactory receptor family 5 subfamily L member 2, HGNC:8351) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5L2 (Q8NGL0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26338 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 56 total
• MANE Select transcript: NM_001004739

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8351
Approved symbol	OR5L2
Name	olfactory receptor family 5 subfamily L member 2
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	HTPCRX16, HSHTPCRX16
Ensembl gene	ENSG00000205030
Ensembl biotype	protein_coding
Entrez	26338

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000378397

RefSeq mRNA: 1 — MANE Select: NM_001004739 NM_001004739

CCDS: CCDS31511

Canonical transcript exons

ENST00000378397 — 1 exons

Exon	Start	End
ENSE00001791207	55827219	55828154

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 57.36.

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
upper leg skin	UBERON:0004262	57.36	silver quality
amniotic fluid	UBERON:0000173	48.98	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
vastus lateralis	UBERON:0001379	41.41	gold quality
quadriceps femoris	UBERON:0001377	41.37	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
granulocyte	CL:0000094	41.07	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
epithelium of nasopharynx	UBERON:0001951	40.45	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
germinal epithelium of ovary	UBERON:0001304	40.33	gold quality
esophagus squamous epithelium	UBERON:0006920	40.29	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	40.27	gold quality
jejunum	UBERON:0002115	40.18	gold quality
cartilage tissue	UBERON:0002418	40.06	gold quality
mammary duct	UBERON:0001765	39.98	gold quality
mucosa of sigmoid colon	UBERON:0004993	39.95	gold quality
skin of hip	UBERON:0001554	39.86	silver quality
deltoid	UBERON:0001476	39.83	gold quality
saphenous vein	UBERON:0007318	39.83	gold quality
parotid gland	UBERON:0001831	39.81	gold quality
oocyte	CL:0000023	39.80	gold quality
urethra	UBERON:0000057	39.80	gold quality
heart right ventricle	UBERON:0002080	39.79	gold quality
pericardium	UBERON:0002407	39.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5l14	ENSMUSG00000075143
mus_musculus	Or5l13	ENSMUSG00000075144
rattus_norvegicus		ENSRNOG00000080593
rattus_norvegicus	Or5l14b	ENSRNOG00000082542
rattus_norvegicus	Or5l13	ENSRNOG00000091137

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5L2 — Q8NGL0 (reviewed: Q8NGL0)

Alternative names: HTPCRX16, Olfactory receptor OR11-153

All UniProt accessions (1): Q8NGL0

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004739* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, glycosylation site 2, sequence variant 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGL0-F1	89.60	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 5, 195

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 25 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GSE15659_TREG_VS_TCONV_UP, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

344 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5L2	KRTAP19-8	Q3LI54	581
OR5L2	AKAP3	O75969	518
OR5L2	KRTAP10-1	P60331	506
OR5L2	FRMPD3	Q5JV73	435
OR5L2	KNOP1	Q1ED39	417
OR5L2	TRIM48	Q8IWZ4	395
OR5L2	PRKACA	P17612	388
OR5L2	PRKACB	P22694	388
OR5L2	PRKACG	P22612	388
OR5L2	TRIM51	Q9BSJ1	371
OR5L2	GPATCH4	Q5T3I0	368
OR5L2	RPUSD3	Q6P087	348
OR5L2	TAAR8	Q969N4	338
OR5L2	MRM1	Q6IN84	337
OR5L2	OTOG	Q6ZRI0	335

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6ND48, B2RN74, O60412, O76099, O76100, O95047, P23271, P23272, P34982, P37069, P37072, P47884, P47890, P58170, Q15622, Q60879, Q8NG84, Q8NG94, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA2, Q8NGE0, Q8NGG1, Q8NGL0, Q8NGP2, Q8NGS2, Q8NGW1, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07, Q8NH80, Q8NHA4, Q8NHC7, Q8VEY3, Q8VFC9, Q8WZA6

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	49
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

178 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55827535:C:G	acceptor_gain	0.8600
11:55827537:T:G	acceptor_gain	0.8400
11:55827534:A:AG	acceptor_gain	0.8300
11:55827621:ACCAT:A	donor_gain	0.7700
11:55827539:T:TA	acceptor_gain	0.7500
11:55827674:G:GT	donor_gain	0.7200
11:55827774:A:G	acceptor_gain	0.7200
11:55827921:C:T	donor_gain	0.7100
11:55827536:ATGT:A	acceptor_gain	0.7000
11:55827364:TTCAG:T	donor_loss	0.6900
11:55827365:TCAGG:T	donor_loss	0.6900
11:55827366:CAGGT:C	donor_loss	0.6900
11:55827367:AGGTC:A	donor_loss	0.6900
11:55827368:GGTCA:G	donor_loss	0.6900
11:55827369:GTCAG:G	donor_loss	0.6900
11:55827370:T:G	donor_loss	0.6900
11:55827485:CAAAG:C	acceptor_gain	0.6600
11:55827534:ACAT:A	acceptor_gain	0.6600
11:55827487:AAGCC:A	acceptor_gain	0.6400
11:55827488:AGCCA:A	acceptor_gain	0.6400
11:55827536:ATGTG:A	acceptor_gain	0.6400
11:55827285:T:G	donor_gain	0.6300
11:55827681:T:A	donor_gain	0.6300
11:55827900:A:G	donor_gain	0.6300
11:55827479:CAAGG:C	acceptor_gain	0.6200
11:55827480:AAGGA:A	acceptor_gain	0.6200
11:55827481:AGGAC:A	acceptor_gain	0.6200
11:55827486:AAAGC:A	acceptor_gain	0.6200
11:55827674:G:T	donor_gain	0.6200
11:55827371:CAG:C	donor_loss	0.5800

AlphaMissense

2030 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55827252:T:C	F12L	0.834
11:55827254:C:A	F12L	0.834
11:55827254:C:G	F12L	0.834
11:55827747:T:C	F177L	0.738
11:55827749:C:A	F177L	0.738
11:55827749:C:G	F177L	0.738
11:55827585:T:C	F123L	0.695
11:55827587:T:A	F123L	0.695
11:55827587:T:G	F123L	0.695
11:55827930:T:C	F238L	0.694
11:55827932:C:A	F238L	0.694
11:55827932:C:G	F238L	0.694
11:55827528:T:C	F104L	0.673
11:55827530:T:A	F104L	0.673
11:55827530:T:G	F104L	0.673
11:55827309:T:C	F31L	0.664
11:55827311:C:A	F31L	0.664
11:55827311:C:G	F31L	0.664
11:55827750:T:C	F178L	0.662
11:55827752:C:A	F178L	0.662
11:55827752:C:G	F178L	0.662
11:55827519:T:C	F101L	0.606
11:55827521:C:A	F101L	0.606
11:55827521:C:G	F101L	0.606
11:55827555:T:C	F113L	0.573
11:55827557:C:A	F113L	0.573
11:55827557:C:G	F113L	0.573
11:55828089:A:C	S291R	0.570
11:55828091:C:A	S291R	0.570
11:55828091:C:G	S291R	0.570

dbSNP variants (sampled 300 via entrez): RS1000012435 (11:55826221 A>G), RS1000085459 (11:55826032 A>G), RS1000726862 (11:55827189 T>C), RS1000778154 (11:55827367 A>G,T), RS1003376437 (11:55828393 CATT>C), RS1003489721 (11:55828226 T>A,C), RS1003560520 (11:55825732 A>T), RS1004058710 (11:55826005 T>C), RS1005515552 (11:55825548 C>A,G), RS1005627067 (11:55827971 C>G,T), RS1008212829 (11:55828650 T>C), RS1008826953 (11:55826624 T>C), RS1009486882 (11:55826027 G>A), RS1010125611 (11:55826632 A>G,T), RS1010272372 (11:55825804 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST008839_600	Height	2.000000e-10

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cupric oxide	increases expression	1
Antirheumatic Agents	increases expression	1
Cadmium Chloride	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.