OR5M1

Summary

OR5M1 (olfactory receptor family 5 subfamily M member 1, HGNC:8352) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5M1 (Q8NGP8). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390168 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 52 total
• MANE Select transcript: NM_001004740

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8352
Approved symbol	OR5M1
Name	olfactory receptor family 5 subfamily M member 1
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	OST050
Ensembl gene	ENSG00000255012
Ensembl biotype	protein_coding
Entrez	390168

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641076

RefSeq mRNA: 1 — MANE Select: NM_001004740 NM_001004740

CCDS: CCDS53631

Canonical transcript exons

ENST00000641076 — 2 exons

Exon	Start	End
ENSE00003812567	56609236	56613519
ENSE00003814078	56614857	56614874

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 74.56.

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.56	gold quality
stromal cell of endometrium	CL:0002255	38.79	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	34.96	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
tonsil	UBERON:0002372	32.02	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
monocyte	CL:0000576	29.99	gold quality
leukocyte	CL:0000738	29.77	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.57	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
islet of Langerhans	UBERON:0000006	26.88	gold quality
urinary bladder	UBERON:0001255	26.81	gold quality
blood	UBERON:0000178	26.53	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
right coronary artery	UBERON:0001625	26.36	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.20	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.78

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5m10	ENSMUSG00000050128
mus_musculus	Or5m10b	ENSMUSG00000057761
rattus_norvegicus	Or5m10b	ENSRNOG00000058567
rattus_norvegicus	Or5m10	ENSRNOG00000060260

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5M1 — Q8NGP8 (reviewed: Q8NGP8)

Alternative names: OST050, Olfactory receptor OR11-208

All UniProt accessions (1): Q8NGP8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004740* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGP8-F1	89.72	0.70

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

162 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5M1	LINC03042	Q6ZUL3	479
OR5M1	TGDS	O95455	358
OR5M1	ATAD3B	Q5T9A4	352
OR5M1	ZNF208	O43345	311
OR5M1	ANO2	Q9NQ90	308
OR5M1	FCF1	Q9Y324	306
OR5M1	GNG13	Q9P2W3	304
OR5M1	GNG8	Q9UK08	293
OR5M1	NKAPD1	Q6ZUT1	287
OR5M1	ADCY3	O60266	278
OR5M1	CNGA2	Q16280	274
OR5M1	TEX22	C9J3V5	271
OR5M1	VPS13B	Q7Z7G8	265
OR5M1	ZFYVE26	Q68DK2	258
OR5M1	NBPF1	Q3BBV0	256

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NCV1, O95221, P0C7N1, P0C7N5, Q60881, Q60888, Q6IEU7, Q8NGA8, Q8NGB6, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD4, Q8NGD5, Q8NGE8, Q8NGF8, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGM9, Q8NGP8, Q8NGP9, Q8NGS9, Q8NGT0, Q8NH01, Q8NH10, Q8NH18, Q8NH21, Q8NH41, Q8NH42, Q8NH43, Q8NH49, Q8NH69, Q8NH85, Q8VEW5, Q8VF65, Q8VFD3

Diamond homologs: A4D2G3, A6NCV1, A6NF89, A6NFC9, A6NIJ9, A6NJZ3, A6NL26, O14581, O76000, O76001, O76002, O76099, O76100, O95221, O95371, O95918, P0DN82, P23275, P34984, P35898, P58173, P58182, P59922, P70526, Q13607, Q15615, Q15622, Q5JQS5, Q5TZ20, Q60883, Q60887, Q60889, Q60890, Q60892, Q60894, Q6IEU7, Q6IF82, Q7TR96, Q7Z3T1, Q8N628

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	49
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

298 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56613097:T:TA	donor_gain	0.9700
11:56613352:T:TA	donor_gain	0.9400
11:56613137:G:C	donor_gain	0.9300
11:56613173:A:AC	donor_gain	0.9000
11:56613215:T:TA	donor_gain	0.7900
11:56613174:G:C	donor_gain	0.7800
11:56612833:C:CC	acceptor_gain	0.7600
11:56613054:A:C	donor_gain	0.7400
11:56613380:G:A	donor_gain	0.7400
11:56613038:A:AC	donor_gain	0.7200
11:56613039:C:CC	donor_gain	0.7200
11:56613136:A:AC	donor_gain	0.7200
11:56612836:C:CT	acceptor_gain	0.7000
11:56612841:A:AC	acceptor_gain	0.7000
11:56612828:GATCG:G	acceptor_gain	0.6900
11:56612831:CG:C	acceptor_gain	0.6900
11:56613066:G:C	donor_gain	0.6900
11:56613177:A:AC	donor_gain	0.6900
11:56612830:TCG:T	acceptor_gain	0.6800
11:56612831:CGC:C	acceptor_gain	0.6800
11:56612837:A:T	acceptor_gain	0.6800
11:56613068:G:T	donor_gain	0.6800
11:56613430:T:TA	donor_gain	0.6700
11:56612833:C:T	acceptor_loss	0.6600
11:56612834:T:A	acceptor_loss	0.6600
11:56612841:A:C	acceptor_gain	0.6600
11:56612888:AAAG:A	donor_gain	0.6400
11:56613130:C:CT	donor_gain	0.6400
11:56613131:T:TT	donor_gain	0.6400
11:56613327:A:C	donor_gain	0.6400

AlphaMissense

2083 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56613467:G:C	F12L	0.937
11:56613467:G:T	F12L	0.937
11:56613469:A:G	F12L	0.937
11:56612972:G:C	F177L	0.915
11:56612972:G:T	F177L	0.915
11:56612974:A:G	F177L	0.915
11:56612999:G:C	F168L	0.900
11:56612999:G:T	F168L	0.900
11:56613001:A:G	F168L	0.900
11:56612657:G:C	S282R	0.844
11:56612657:G:T	S282R	0.844
11:56612659:T:G	S282R	0.844
11:56613468:A:G	F12S	0.836
11:56613138:C:G	R122P	0.828
11:56612630:G:C	S291R	0.822
11:56612630:G:T	S291R	0.822
11:56612632:T:G	S291R	0.822
11:56613191:G:C	F104L	0.822
11:56613191:G:T	F104L	0.822
11:56613193:A:G	F104L	0.822
11:56613410:G:C	F31L	0.822
11:56613410:G:T	F31L	0.822
11:56613412:A:G	F31L	0.822
11:56612795:T:A	K236N	0.814
11:56612795:T:G	K236N	0.814
11:56612876:G:C	S209R	0.812
11:56612876:G:T	S209R	0.812
11:56612878:T:G	S209R	0.812
11:56612750:A:C	F251L	0.784
11:56612750:A:T	F251L	0.784

dbSNP variants (sampled 300 via entrez): RS1000876154 (11:56616236 A>C), RS1000909146 (11:56614185 T>C), RS1001227728 (11:56612332 T>A), RS1001260151 (11:56612599 G>C,T), RS1001967 (11:56612252 C>A,G,T), RS1002764767 (11:56615875 C>A), RS1002929023 (11:56611139 A>G,T), RS1003206034 (11:56614202 G>A), RS1003876870 (11:56616431 A>C), RS1004272065 (11:56615934 C>G,T), RS1004420498 (11:56610200 A>T), RS1004450221 (11:56610404 A>C,G), RS1004482424 (11:56610675 C>A), RS1004490738 (11:56614148 C>T), RS1006354557 (11:56614606 C>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	affects methylation	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.