OR5M10

Summary

OR5M10 (olfactory receptor family 5 subfamily M member 10, HGNC:15290) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5M10 (Q6IEU7). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390167 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_001004741

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15290
Approved symbol	OR5M10
Name	olfactory receptor family 5 subfamily M member 10
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000254834
Ensembl biotype	protein_coding
Entrez	390167

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000526538

RefSeq mRNA: 1 — MANE Select: NM_001004741 NM_001004741

CCDS: CCDS53630

Canonical transcript exons

ENST00000526538 — 1 exons

Exon	Start	End
ENSE00002176915	56576774	56577721

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 38.72.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	38.72	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.60	gold quality
duodenum	UBERON:0002114	28.14	gold quality
right coronary artery	UBERON:0001625	27.64	gold quality
lymph node	UBERON:0000029	27.57	gold quality
leukocyte	CL:0000738	27.17	gold quality
monocyte	CL:0000576	27.12	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.84	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.23	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.14	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.53	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5m10	ENSMUSG00000050128
mus_musculus	Or5m10b	ENSMUSG00000057761
rattus_norvegicus	Or5m10b	ENSRNOG00000058567
rattus_norvegicus	Or5m10	ENSRNOG00000060260

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5M10 — Q6IEU7 (reviewed: Q6IEU7)

Alternative names: Olfactory receptor OR11-207

All UniProt accessions (1): Q6IEU7

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004741* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6IEU7-F1	89.09	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

166 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5M10	KRTAP19-8	Q3LI54	608
OR5M10	CCDC126	Q96EE4	532
OR5M10	KRTAP5-7	Q6L8G8	507
OR5M10	ASB17	Q8WXJ9	501
OR5M10	DPY19L3	Q6ZPD9	467
OR5M10	KRTAP5-11	Q6L8G4	434
OR5M10	KRTAP5-5	Q701N2	432
OR5M10	GALNTL5	Q7Z4T8	420
OR5M10	ENOX1	Q8TC92	405
OR5M10	RAP1GDS1	P52306	396
OR5M10	NKAIN2	Q5VXU1	374
OR5M10	PCDHB14	Q9Y5E9	372
OR5M10	ANO3	Q9BYT9	328
OR5M10	KHDRBS2	Q5VWX1	327
OR5M10	GNG13	Q9P2W3	323

IntAct

0 interactions, top by confidence:

BioGRID (1): OR5M10 (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NCV1, O95221, P0C7N1, P0C7N5, Q60881, Q60888, Q6IEU7, Q8NGA8, Q8NGB6, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD4, Q8NGD5, Q8NGE8, Q8NGF8, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGM9, Q8NGP8, Q8NGP9, Q8NGS9, Q8NGT0, Q8NH01, Q8NH10, Q8NH18, Q8NH21, Q8NH41, Q8NH42, Q8NH43, Q8NH49, Q8NH69, Q8NH85, Q8VEW5, Q8VF65, Q8VFD3

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	56
Likely benign	6
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

267 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56577571:T:TA	donor_gain	0.9200
11:56577316:T:TA	donor_gain	0.9000
11:56577392:A:AC	donor_gain	0.8500
11:56577599:G:A	donor_gain	0.8300
11:56577434:T:TA	donor_gain	0.8000
11:56577356:G:C	donor_gain	0.7900
11:56577393:G:C	donor_gain	0.7800
11:56577052:C:CC	acceptor_gain	0.7400
11:56577603:G:A	donor_gain	0.7300
11:56577056:A:T	acceptor_gain	0.7200
11:56577047:GATCG:G	acceptor_gain	0.7100
11:56577055:C:CT	acceptor_gain	0.7000
11:56577396:A:AC	donor_gain	0.7000
11:56577060:A:AC	acceptor_gain	0.6900
11:56577399:A:AC	donor_gain	0.6800
11:56577060:A:C	acceptor_gain	0.6600
11:56577649:T:TA	donor_gain	0.6600
11:56577050:CG:C	acceptor_gain	0.6500
11:56577051:GC:G	acceptor_loss	0.6500
11:56577129:G:A	donor_gain	0.6500
11:56577049:TCG:T	acceptor_gain	0.6400
11:56577050:CGC:C	acceptor_gain	0.6400
11:56577107:AAAG:A	donor_gain	0.6400
11:56577273:A:C	donor_gain	0.6400
11:56577118:C:CT	donor_gain	0.6200
11:56577119:T:TT	donor_gain	0.6200
11:56577136:TTTTG:T	donor_gain	0.6200
11:56577287:G:T	donor_gain	0.6200
11:56577514:C:CT	donor_gain	0.6200
11:56577515:T:TT	donor_gain	0.6200

AlphaMissense

2083 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56613467:G:C	F12L	0.937
11:56613467:G:T	F12L	0.937
11:56613469:A:G	F12L	0.937
11:56612972:G:C	F177L	0.915
11:56612972:G:T	F177L	0.915
11:56612974:A:G	F177L	0.915
11:56612999:G:C	F168L	0.900
11:56612999:G:T	F168L	0.900
11:56613001:A:G	F168L	0.900
11:56612657:G:C	S282R	0.844
11:56612657:G:T	S282R	0.844
11:56612659:T:G	S282R	0.844
11:56613468:A:G	F12S	0.836
11:56613138:C:G	R122P	0.828
11:56612630:G:C	S291R	0.822
11:56612630:G:T	S291R	0.822
11:56612632:T:G	S291R	0.822
11:56613191:G:C	F104L	0.822
11:56613191:G:T	F104L	0.822
11:56613193:A:G	F104L	0.822
11:56613410:G:C	F31L	0.822
11:56613410:G:T	F31L	0.822
11:56613412:A:G	F31L	0.822
11:56612795:T:A	K236N	0.814
11:56612795:T:G	K236N	0.814
11:56612876:G:C	S209R	0.812
11:56612876:G:T	S209R	0.812
11:56612878:T:G	S209R	0.812
11:56612750:A:C	F251L	0.784
11:56612750:A:T	F251L	0.784

dbSNP variants (sampled 300 via entrez): RS1001764636 (11:56578461 C>G,T), RS1003471730 (11:56577622 T>A,G), RS1005448875 (11:56579706 G>A,T), RS1006054292 (11:56576679 C>G,T), RS1007716626 (11:56577811 A>G), RS1008882052 (11:56579098 T>C), RS1008916150 (11:56579361 T>C), RS1009904037 (11:56579101 G>C,T), RS1009965628 (11:56578632 T>C), RS1010411291 (11:56578844 G>A,T), RS1010443079 (11:56578744 G>T), RS1010474195 (11:56578977 T>C), RS1011109825 (11:56576578 A>C,G), RS1014477926 (11:56578342 A>G), RS1018231575 (11:56578882 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-palmitoylglycerol	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Acetaminophen	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.