OR5M11

Summary

OR5M11 (olfactory receptor family 5 subfamily M member 11, HGNC:15291) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5M11 (Q96RB7). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219487 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 44 total
• MANE Select transcript: NM_001005245

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15291
Approved symbol	OR5M11
Name	olfactory receptor family 5 subfamily M member 11
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	OR11-199
Ensembl gene	ENSG00000255223
Ensembl biotype	protein_coding
Entrez	219487

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000528616

RefSeq mRNA: 1 — MANE Select: NM_001005245 NM_001005245

CCDS: CCDS53629

Canonical transcript exons

ENST00000528616 — 1 exons

Exon	Start	End
ENSE00002160404	56542340	56543257

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 37.20.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
mucosa of transverse colon	UBERON:0004991	36.49	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
urinary bladder	UBERON:0001255	33.06	gold quality
monocyte	CL:0000576	32.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
leukocyte	CL:0000738	31.95	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
tonsil	UBERON:0002372	28.68	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.61	gold quality
lymph node	UBERON:0000029	27.57	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.10	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.87	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.15	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5m11	ENSMUSG00000057207
mus_musculus	Or5m11b	ENSMUSG00000059873
rattus_norvegicus	Or5m11	ENSRNOG00000033994
rattus_norvegicus	Or5m11	ENSRNOG00000049901

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5M11 — Q96RB7 (reviewed: Q96RB7)

All UniProt accessions (2): Q96RB7, A0A126GVL9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005245* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96RB7-F1	87.89	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr11q12

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

228 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5M11	CCDC126	Q96EE4	625
OR5M11	ASB17	Q8WXJ9	606
OR5M11	ENOX1	Q8TC92	540
OR5M11	DPY19L3	Q6ZPD9	493
OR5M11	GALNTL5	Q7Z4T8	456
OR5M11	TBC1D3G	Q6DHY5	447
OR5M11	ZNF831	Q5JPB2	429
OR5M11	RAP1GDS1	P52306	420
OR5M11	REX1BD	Q96EN9	419
OR5M11	MYOZ3	Q8TDC0	401
OR5M11	PCDHB14	Q9Y5E9	396
OR5M11	RDH13	Q8NBN7	395
OR5M11	PROZ	P22891	394
OR5M11	ANO3	Q9BYT9	389
OR5M11	TMCC2	O75069	386

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR5M11	RPSA2	psi-mi:“MI:0914”(association)	0.350

BioGRID (2): CLPTM1 (Affinity Capture-MS), RPSAP58 (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NCV1, A6NHA9, A6NMZ5, P0C604, P0C645, P0C7N5, P0DN82, P58182, Q60881, Q62007, Q6IEU7, Q6IEV9, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGD0, Q8NGD2, Q8NGE8, Q8NGF8, Q8NGF9, Q8NGI6, Q8NGL6, Q8NGL7, Q8NGL9, Q8NGM1, Q8NGM8, Q8NGN8, Q8NGP9, Q8NH10, Q8NH21, Q8NH42, Q8NH49, Q8NH72, Q8NH83

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

44 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	42
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

337 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56542389:C:CC	acceptor_gain	0.7800
11:56542418:C:CT	acceptor_gain	0.7500
11:56542425:G:C	acceptor_gain	0.7300
11:56542425:G:GC	acceptor_gain	0.7200
11:56542846:T:A	donor_gain	0.7200
11:56542412:C:CT	acceptor_gain	0.6900
11:56542413:G:T	acceptor_gain	0.6900
11:56542385:CAGA:C	acceptor_gain	0.6800
11:56542484:A:C	acceptor_gain	0.6600
11:56542419:A:AC	donor_gain	0.6400
11:56542420:C:CC	donor_gain	0.6400
11:56542452:T:TA	donor_gain	0.6400
11:56542467:T:C	donor_gain	0.6300
11:56542448:AGATT:A	donor_gain	0.6100
11:56542707:A:C	donor_gain	0.6100
11:56542420:C:CT	acceptor_gain	0.6000
11:56542458:A:C	donor_gain	0.5900
11:56542682:A:C	acceptor_gain	0.5900
11:56542480:T:C	acceptor_gain	0.5800
11:56542488:A:C	acceptor_gain	0.5800
11:56542521:G:GA	donor_gain	0.5800
11:56542957:A:AC	donor_gain	0.5800
11:56542972:A:AT	donor_gain	0.5800
11:56542343:T:C	donor_gain	0.5600
11:56542379:ATT:A	donor_gain	0.5600
11:56542381:T:TA	donor_gain	0.5600
11:56542411:CCGGA:C	acceptor_gain	0.5600
11:56542676:T:TG	acceptor_gain	0.5600
11:56542388:A:AC	acceptor_gain	0.5500
11:56542421:A:T	acceptor_gain	0.5500

AlphaMissense

2000 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56543222:G:C	F12L	0.900
11:56543222:G:T	F12L	0.900
11:56543224:A:G	F12L	0.900
11:56542730:G:C	F176L	0.864
11:56542730:G:T	F176L	0.864
11:56542732:A:G	F176L	0.864
11:56542757:G:C	F167L	0.825
11:56542757:G:T	F167L	0.825
11:56542759:A:G	F167L	0.825
11:56542415:A:C	S281R	0.767
11:56542415:A:T	S281R	0.767
11:56542417:T:G	S281R	0.767
11:56542508:A:C	F250L	0.750
11:56542508:A:T	F250L	0.750
11:56542510:A:G	F250L	0.750
11:56542421:A:C	F279L	0.724
11:56542421:A:T	F279L	0.724
11:56542423:A:G	F279L	0.724
11:56542547:G:C	F237L	0.717
11:56542547:G:T	F237L	0.717
11:56542549:A:G	F237L	0.717
11:56542949:G:C	F103L	0.690
11:56542949:G:T	F103L	0.690
11:56542951:A:G	F103L	0.690
11:56542430:A:C	F276L	0.687
11:56542430:A:T	F276L	0.687
11:56542432:A:G	F276L	0.687
11:56542634:G:C	S208R	0.667
11:56542634:G:T	S208R	0.667
11:56542636:T:G	S208R	0.667

dbSNP variants (sampled 300 via entrez): RS1000235326 (11:56544270 T>A,C), RS1001565587 (11:56542642 G>A,T), RS1005326212 (11:56543543 C>T), RS1005708086 (11:56543808 A>G,T), RS1006395050 (11:56545086 T>C), RS1006427820 (11:56542233 A>G), RS1006744236 (11:56544873 G>A), RS1006754397 (11:56544890 G>A), RS1006833405 (11:56543185 A>G), RS1007691754 (11:56543300 A>G), RS1007702130 (11:56544231 A>G,T), RS1007837570 (11:56544499 G>A,T), RS1008157283 (11:56543537 A>G), RS1010020762 (11:56544506 C>G), RS1010306151 (11:56542930 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Acetaminophen	increases expression	1
Endosulfan	decreases expression	1
Phthalic Acids	decreases expression	1
Plant Extracts	decreases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.