OR5M3

Summary

OR5M3 (olfactory receptor family 5 subfamily M member 3, HGNC:14806) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5M3 (Q8NGP4). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219482 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 57 total
• MANE Select transcript: NM_001004742

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14806
Approved symbol	OR5M3
Name	olfactory receptor family 5 subfamily M member 3
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000174937
Ensembl biotype	protein_coding
Entrez	219482

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641993

RefSeq mRNA: 1 — MANE Select: NM_001004742 NM_001004742

CCDS: CCDS31532

Canonical transcript exons

ENST00000641993 — 2 exons

Exon	Start	End
ENSE00003811893	56473221	56473352
ENSE00003812381	56469274	56470541

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.79	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.55	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
leukocyte	CL:0000738	27.36	gold quality
monocyte	CL:0000576	27.33	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.71	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.09	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.17	gold quality
ectocervix	UBERON:0012249	25.08	gold quality
calcaneal tendon	UBERON:0003701	24.95	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5m3	ENSMUSG00000042796
mus_musculus	Or5m3b	ENSMUSG00000045392
rattus_norvegicus	Or5m3b	ENSRNOG00000074754
rattus_norvegicus	Or5m3	ENSRNOG00000086615

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 5M3 — Q8NGP4 (reviewed: Q8NGP4)

Alternative names: Olfactory receptor OR11-191

All UniProt accessions (1): Q8NGP4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004742* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGP4-F1	92.32	0.80

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

162 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5M3	C10orf62	Q5T681	604
OR5M3	CFAP141	Q5VU69	576
OR5M3	ZNF285	Q96NJ3	506
OR5M3	XAGE5	Q8WWM1	477
OR5M3	ARMCX6	Q7L4S7	475
OR5M3	DRG1	Q9Y295	396
OR5M3	TAS2R46	P59540	390
OR5M3	TRAPPC6B	Q86SZ2	371
OR5M3	TMPRSS11E	Q9UL52	363
OR5M3	PASK	Q96RG2	357
OR5M3	SLC12A9	Q9BXP2	353
OR5M3	NIBAN3	Q86XR2	349
OR5M3	TAS2R4	Q9NYW5	348
OR5M3	ARHGAP11B	Q3KRB8	314
OR5M3	SERF1A	O75920	303
OR5M3	OR4C13	Q8NGP0	303

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR5M3	TAX1BP1	psi-mi:“MI:0914”(association)	0.350

BioGRID (3): OR5M3 (Affinity Capture-MS), TAX1BP1 (Affinity Capture-MS), RNF181 (Affinity Capture-MS)

ESM2 similar proteins: P34982, P34986, P37071, Q60886, Q7TR96, Q8N146, Q8NG75, Q8NGG0, Q8NGG1, Q8NGI9, Q8NGL3, Q8NGP2, Q8NGP3, Q8NGP4, Q8NGP6, Q8NGQ6, Q8NGS7, Q8NGU2, Q8NGV7, Q8NGZ3, Q8NH48, Q8NH50, Q8NHC8, Q8VES2, Q8VEZ0, Q8VF13, Q8VF65, Q8VF66, Q8VFD1, Q8VFD2, Q8VFX2, Q8VG03, Q8VG04, Q8VG05, Q8VG06, Q8VG07, Q8VG08, Q8VG09, Q8VG42, Q8VGI4

Diamond homologs: A6NL26, O95221, P0C617, P0C626, P0C7N1, P0C7N5, P0C7N8, P0DMU2, P37068, P37070, P37071, P37072, Q13606, Q15617, Q15620, Q60880, Q60882, Q60886, Q60893, Q60894, Q60895, Q6IEU7, Q6UXT6, Q7TR96, Q8N0Y5, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NGC0, Q8NGE9, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2, Q8NGG3, Q8NGG4, Q8NGG5, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

171 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56470050:C:CT	acceptor_gain	0.9800
11:56469747:C:CT	acceptor_gain	0.9700
11:56470051:A:C	acceptor_gain	0.9600
11:56470043:A:T	acceptor_gain	0.9500
11:56470051:A:T	acceptor_gain	0.9300
11:56470042:C:CT	acceptor_gain	0.9100
11:56469836:A:AC	acceptor_gain	0.8900
11:56469748:A:C	acceptor_gain	0.8800
11:56470039:C:CT	acceptor_gain	0.8600
11:56470050:C:T	acceptor_gain	0.8600
11:56469731:A:C	acceptor_gain	0.8200
11:56469739:CAGAG:C	acceptor_gain	0.8200
11:56469836:A:C	acceptor_gain	0.8100
11:56470434:G:A	donor_gain	0.8000
11:56470049:CCA:C	acceptor_gain	0.7600
11:56469718:ACGTC:A	acceptor_gain	0.7400
11:56469719:CGTCT:C	acceptor_gain	0.7400
11:56469720:GTCTG:G	acceptor_gain	0.7400
11:56470038:TCGTC:T	acceptor_gain	0.7400
11:56469834:CAA:C	acceptor_gain	0.7300
11:56470055:A:C	acceptor_gain	0.7200
11:56469719:CGT:C	acceptor_gain	0.7000
11:56469748:A:T	acceptor_gain	0.6700
11:56470051:A:AC	acceptor_gain	0.6700
11:56470349:CTGA:C	donor_loss	0.6400
11:56470350:TGA:T	donor_loss	0.6400
11:56470351:GACCT:G	donor_loss	0.6400
11:56470352:ACCTT:A	donor_loss	0.6400
11:56470353:C:CA	donor_loss	0.6400
11:56469968:C:A	acceptor_gain	0.6300

AlphaMissense

2035 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56470036:A:C	S154R	0.984
11:56470036:A:T	S154R	0.984
11:56470038:T:G	S154R	0.984
11:56470468:G:C	F10L	0.976
11:56470468:G:T	F10L	0.976
11:56470470:A:G	F10L	0.976
11:56469973:G:C	F175L	0.975
11:56469973:G:T	F175L	0.975
11:56469975:A:G	F175L	0.975
11:56469631:A:C	S289R	0.946
11:56469631:A:T	S289R	0.946
11:56469633:T:G	S289R	0.946
11:56470469:A:G	F10S	0.946
11:56469953:A:T	L182H	0.938
11:56470000:G:C	F166L	0.935
11:56470000:G:T	F166L	0.935
11:56470002:A:G	F166L	0.935
11:56469968:C:G	C177S	0.932
11:56469969:A:T	C177S	0.932
11:56470049:C:T	G150D	0.932
11:56469953:A:G	L182P	0.929
11:56469974:A:G	F175S	0.925
11:56469963:C:G	D179H	0.923
11:56470050:C:G	G150R	0.923
11:56470378:A:C	N40K	0.923
11:56470378:A:T	N40K	0.923
11:56470285:A:C	F71L	0.919
11:56470285:A:T	F71L	0.919
11:56470287:A:G	F71L	0.919
11:56469886:G:C	N204K	0.918

dbSNP variants (sampled 300 via entrez): RS1000363473 (11:56472244 A>C,G), RS1000415863 (11:56471997 G>C), RS1000962542 (11:56474339 A>G,T), RS1001235970 (11:56471416 A>T), RS1001260043 (11:56468878 A>T), RS1001924448 (11:56471354 T>C), RS1002234204 (11:56472681 A>G,T), RS1002309354 (11:56472880 A>G), RS1003734912 (11:56472451 A>C), RS1003859516 (11:56472103 A>G), RS1004177314 (11:56474694 T>C), RS1004240574 (11:56474949 C>T), RS1004314315 (11:56475311 T>C), RS1004894818 (11:56470914 A>C,G), RS1005530594 (11:56473257 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.