OR5M8

Summary

OR5M8 (olfactory receptor family 5 subfamily M member 8, HGNC:14846) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5M8 (Q8NGP6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219484 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 60 total
• MANE Select transcript: NM_001005282

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14846
Approved symbol	OR5M8
Name	olfactory receptor family 5 subfamily M member 8
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181371
Ensembl biotype	protein_coding
Entrez	219484

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000327216

RefSeq mRNA: 1 — MANE Select: NM_001005282 NM_001005282

CCDS: CCDS31533

Canonical transcript exons

ENST00000327216 — 1 exons

Exon	Start	End
ENSE00001269857	56490435	56491370

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 97.59.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.59	gold quality
sural nerve	UBERON:0015488	41.18	gold quality
lower esophagus mucosa	UBERON:0035834	39.17	gold quality
granulocyte	CL:0000094	37.38	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.22	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
leukocyte	CL:0000738	26.87	gold quality
urinary bladder	UBERON:0001255	26.85	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.21	gold quality
monocyte	CL:0000576	26.15	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
calcaneal tendon	UBERON:0003701	25.00	gold quality
muscle of leg	UBERON:0001383	24.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5m8	ENSMUSG00000043267
rattus_norvegicus	Or5m8	ENSRNOG00000009670

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 5M8 — Q8NGP6 (reviewed: Q8NGP6)

Alternative names: Olfactory receptor OR11-194

All UniProt accessions (2): A0A126GWD6, Q8NGP6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005282* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGP6-F1	89.92	0.63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (1): 4

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

90 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5M8	ELAPOR2	A8MWY0	575
OR5M8	PRB4	P02813	506
OR5M8	ZNF366	Q8N895	474
OR5M8	ZNF281	Q9Y2X9	370
OR5M8	EIF4E2	O60573	369
OR5M8	TAS2R19	P59542	348
OR5M8	WNT10A	Q9GZT5	259
OR5M8	DNM1	Q05193	257
OR5M8	TAS2R14	Q9NYV8	256
OR5M8	FIBIN	Q8TAL6	251
OR5M8	HTR2A	P28223	220
OR5M8	GALNT18	Q6P9A2	214
OR5M8	DHX58	Q96C10	203
OR5M8	TAS2R38	P59533	203
OR5M8	ENSA	O43768	194

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR5M8	UBE3A	psi-mi:“MI:0914”(association)	0.350

BioGRID (4): UBE3A (Affinity Capture-MS), RNF181 (Affinity Capture-MS), UNC45B (Affinity Capture-MS), OR5M8 (PCA)

ESM2 similar proteins: A6NL08, O76000, O95221, P0C626, P0C629, P0C7N1, P0C7N5, P0DMU2, P0DN81, P30955, P58173, P58181, P59922, P70526, Q15617, Q15620, Q60882, Q60890, Q60893, Q60895, Q6IEU7, Q8NG81, Q8NGF4, Q8NGG4, Q8NGG6, Q8NGH3, Q8NGI9, Q8NGP6, Q8NGP8, Q8NGP9, Q8NGR5, Q8NGS4, Q8NGT0, Q8NGT1, Q8NGZ4, Q8NGZ9, Q8NH01, Q8NH04, Q8NH69, Q8VF76

Diamond homologs: A6NL26, O95221, P0C617, P0C626, P0C7N1, P0C7N5, P0C7N8, P0DMU2, P37068, P37070, P37071, P37072, Q13606, Q15617, Q15620, Q60880, Q60882, Q60886, Q60893, Q60894, Q60895, Q6IEU7, Q6UXT6, Q7TR96, Q8N0Y5, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NGC0, Q8NGE9, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2, Q8NGG3, Q8NGG4, Q8NGG5, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

60 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

290 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56491075:TG:T	donor_gain	0.7100
11:56491109:T:TA	donor_gain	0.7100
11:56491310:C:A	donor_gain	0.6600
11:56490671:G:A	donor_gain	0.6100
11:56491309:T:TA	donor_gain	0.6100
11:56491306:AATTC:A	donor_gain	0.6000
11:56491345:G:C	donor_gain	0.6000
11:56490532:A:AC	donor_gain	0.5900
11:56490533:C:CC	donor_gain	0.5900
11:56491198:A:C	donor_gain	0.5900
11:56490924:CA:C	donor_gain	0.5800
11:56490577:T:A	donor_gain	0.5700
11:56490957:A:AC	donor_gain	0.5700
11:56490958:C:CC	donor_gain	0.5700
11:56491147:T:TC	acceptor_gain	0.5700
11:56491256:C:CT	donor_gain	0.5700
11:56491341:CTCAG:C	donor_gain	0.5700
11:56491342:TCAGT:T	donor_gain	0.5700
11:56491343:CAGTC:C	donor_gain	0.5700
11:56491344:AGTCA:A	donor_gain	0.5700
11:56490561:AC:A	donor_gain	0.5600
11:56490562:CC:C	donor_gain	0.5600
11:56490958:CT:C	donor_gain	0.5600
11:56491141:G:C	donor_gain	0.5600
11:56491193:A:AC	donor_gain	0.5500
11:56490675:G:A	donor_gain	0.5200
11:56490695:T:G	acceptor_gain	0.5200
11:56491251:C:A	donor_gain	0.5200
11:56491254:TGC:T	donor_gain	0.5200
11:56490575:ATT:A	donor_gain	0.5100

AlphaMissense

2049 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56491338:G:C	F11L	0.925
11:56491338:G:T	F11L	0.925
11:56491340:A:G	F11L	0.925
11:56490870:G:C	F167L	0.874
11:56490870:G:T	F167L	0.874
11:56490872:A:G	F167L	0.874
11:56490843:G:C	F176L	0.732
11:56490843:G:T	F176L	0.732
11:56490845:A:G	F176L	0.732
11:56491062:A:C	F103L	0.723
11:56491062:A:T	F103L	0.723
11:56491064:A:G	F103L	0.723
11:56491290:G:C	F27L	0.712
11:56491290:G:T	F27L	0.712
11:56491292:A:G	F27L	0.712
11:56491281:A:C	F30L	0.703
11:56491281:A:T	F30L	0.703
11:56491283:A:G	F30L	0.703
11:56490789:C:A	K194N	0.701
11:56490789:C:G	K194N	0.701
11:56490621:G:C	F250L	0.683
11:56490621:G:T	F250L	0.683
11:56490623:A:G	F250L	0.683
11:56491339:A:G	F11S	0.682
11:56490660:A:C	F237L	0.657
11:56490660:A:T	F237L	0.657
11:56490662:A:G	F237L	0.657
11:56491155:G:C	F72L	0.635
11:56491155:G:T	F72L	0.635
11:56491157:A:G	F72L	0.635

dbSNP variants (sampled 300 via entrez): RS1001900621 (11:56491837 C>T), RS1002839596 (11:56492199 G>C), RS1003063020 (11:56490173 G>T), RS1004776951 (11:56493050 A>T), RS1004811138 (11:56493287 T>C), RS1005303121 (11:56490410 T>G), RS1006239505 (11:56490125 A>T), RS1008577887 (11:56492677 A>T), RS1009225302 (11:56492613 T>A), RS1009277509 (11:56492269 A>G), RS1010232411 (11:56491209 G>A), RS1011189762 (11:56490427 A>G), RS1012746196 (11:56490142 C>A), RS1013822597 (11:56491513 A>T), RS1013853859 (11:56491796 TAA>T,TA)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.