OR5M9

Summary

OR5M9 (olfactory receptor family 5 subfamily M member 9, HGNC:15294) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5M9 (Q8NGP3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390162 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 58 total
• MANE Select transcript: NM_001004743

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15294
Approved symbol	OR5M9
Name	olfactory receptor family 5 subfamily M member 9
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000150269
Ensembl biotype	protein_coding
Entrez	390162

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000279791

RefSeq mRNA: 1 — MANE Select: NM_001004743 NM_001004743

CCDS: CCDS31531

Canonical transcript exons

ENST00000279791 — 1 exons

Exon	Start	End
ENSE00000994295	56462469	56463401

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 41.14.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	41.14	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
sural nerve	UBERON:0015488	36.56	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
leukocyte	CL:0000738	26.14	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
blood	UBERON:0000178	25.81	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
monocyte	CL:0000576	25.21	gold quality
muscle of leg	UBERON:0001383	24.80	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
fundus of stomach	UBERON:0001160	24.45	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5m9b	ENSMUSG00000099820
mus_musculus	Or5m9	ENSMUSG00000102091
rattus_norvegicus	Or5m9	ENSRNOG00000078305

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 5M9 — Q8NGP3 (reviewed: Q8NGP3)

Alternative names: Olfactory receptor OR11-190

All UniProt accessions (2): Q8NGP3, A0A126GVK6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004743* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGP3-F1	89.78	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_A, GAO_LARGE_INTESTINE_ADULT_CE_OLFM4HIGH_STEM_CELL, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

232 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5M9	TSGA10IP	Q3SY00	612
OR5M9	MFSD11	O43934	505
OR5M9	PIGZ	Q86VD9	469
OR5M9	NPAP1	Q9NZP6	435
OR5M9	ABCC12	Q96J65	416
OR5M9	ADAMTS19	Q8TE59	367
OR5M9	ANAPC4	Q9UJX5	357
OR5M9	EPCIP	Q9NYP8	327
OR5M9	IL1RAPL2	Q9NP60	325
OR5M9	FAM149B1	Q96BN6	306
OR5M9	OOSP2	Q86WS3	299
OR5M9	C1orf159	Q96HA4	299
OR5M9	IZUMO4	Q1ZYL8	279
OR5M9	TTLL2	Q9BWV7	256
OR5M9	EPPIN	O95925	248
OR5M9	SLX4	Q8IY92	248

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NDL8, P0C7N8, P37067, P37070, P37071, Q13606, Q60884, Q60886, Q7TR96, Q8N146, Q8N162, Q8NG75, Q8NGE2, Q8NGF7, Q8NGG4, Q8NGI8, Q8NGP3, Q8NGS5, Q8NGV7, Q8NGZ3, Q8NH48, Q8NH87, Q8NHB7, Q8VEW5, Q8VEW6, Q8VEX6, Q8VEZ0, Q8VF13, Q8VF65, Q8VF66, Q8VFB9, Q8VFD1, Q8VFD2, Q8VFX2, Q8VG02, Q8VG03, Q8VG04, Q8VG06, Q8VG07, Q8VG08

Diamond homologs: A6NL26, O95221, P0C617, P0C626, P0C7N1, P0C7N5, P0DMU2, P34983, P34985, P37068, P37070, P37071, P37072, Q13606, Q15617, Q60880, Q60884, Q60893, Q60894, Q60895, Q6IEU7, Q6UXT6, Q8N0Y5, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NG78, Q8NGC0, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2, Q8NGG3, Q8NGG4, Q8NGG7, Q8NGH3, Q8NGI8, Q8NGI9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

255 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56462772:C:CT	acceptor_gain	0.7300
11:56462652:A:C	acceptor_gain	0.6600
11:56462773:G:T	acceptor_gain	0.6600
11:56462650:CCA:C	acceptor_gain	0.6400
11:56463006:A:AC	donor_gain	0.6400
11:56463007:C:CC	donor_gain	0.6400
11:56462866:TC:T	acceptor_loss	0.6100
11:56462867:CT:C	acceptor_loss	0.6100
11:56463201:C:CT	acceptor_gain	0.6100
11:56463340:AGCT:A	donor_gain	0.5900
11:56463341:G:C	donor_gain	0.5900
11:56462741:C:CC	acceptor_gain	0.5800
11:56462651:C:T	acceptor_gain	0.5700
11:56462738:CTA:C	acceptor_gain	0.5700
11:56462874:A:AC	acceptor_loss	0.5700
11:56462544:C:CT	acceptor_gain	0.5600
11:56462584:G:C	donor_gain	0.5600
11:56462752:G:GC	acceptor_gain	0.5600
11:56462837:T:A	donor_gain	0.5600
11:56462867:C:CC	acceptor_gain	0.5600
11:56462768:C:CT	donor_gain	0.5500
11:56463333:A:AT	donor_gain	0.5500
11:56462536:C:CC	acceptor_gain	0.5400
11:56462545:A:C	acceptor_gain	0.5400
11:56462609:ATT:A	donor_gain	0.5400
11:56462869:G:C	acceptor_loss	0.5400
11:56462649:CCCA:C	acceptor_gain	0.5100
11:56462651:CA:C	acceptor_gain	0.5100
11:56463343:T:TA	donor_gain	0.5000
11:56462471:ACTG:A	donor_gain	0.4900

AlphaMissense

2042 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56463372:A:C	F10L	0.900
11:56463372:A:T	F10L	0.900
11:56463374:A:G	F10L	0.900
11:56462877:G:C	F175L	0.865
11:56462877:G:T	F175L	0.865
11:56462879:A:G	F175L	0.865
11:56462940:G:C	S154R	0.851
11:56462940:G:T	S154R	0.851
11:56462942:T:G	S154R	0.851
11:56462904:G:C	F166L	0.843
11:56462904:G:T	F166L	0.843
11:56462906:A:G	F166L	0.843
11:56463315:G:C	F29L	0.821
11:56463315:G:T	F29L	0.821
11:56463317:A:G	F29L	0.821
11:56462655:A:C	F249L	0.775
11:56462655:A:T	F249L	0.775
11:56462657:A:G	F249L	0.775
11:56462577:A:C	F275L	0.740
11:56462577:A:T	F275L	0.740
11:56462579:A:G	F275L	0.740
11:56462694:G:C	F236L	0.736
11:56462694:G:T	F236L	0.736
11:56462696:A:G	F236L	0.736
11:56463189:G:C	F71L	0.730
11:56463189:G:T	F71L	0.730
11:56463191:A:G	F71L	0.730
11:56463096:G:C	F102L	0.717
11:56463096:G:T	F102L	0.717
11:56463098:A:G	F102L	0.717

dbSNP variants (sampled 300 via entrez): RS1000412784 (11:56464561 C>A,T), RS1001024368 (11:56462298 T>C), RS1003031156 (11:56464988 G>T), RS1003835923 (11:56464196 G>A), RS1004390671 (11:56463931 T>G), RS1007011257 (11:56465079 T>A,G), RS1011044579 (11:56463575 T>C,G), RS1012067902 (11:56462934 T>C,G), RS1012552438 (11:56463170 T>G), RS1013140143 (11:56464514 A>C), RS1014446659 (11:56464531 T>A), RS1014846458 (11:56464186 T>A), RS1016272811 (11:56463824 T>C), RS1016303722 (11:56463514 A>G), RS1017138079 (11:56464213 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.