OR5P2

Summary

OR5P2 (olfactory receptor family 5 subfamily P member 2, HGNC:14783) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 5P2 (Q8WZ92). Odorant receptor (Potential).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 120065 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 45 total
• MANE Select transcript: NM_153444

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14783
Approved symbol	OR5P2
Name	olfactory receptor family 5 subfamily P member 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	JCG3
Ensembl gene	ENSG00000183303
Ensembl biotype	protein_coding
Entrez	120065

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000329434

RefSeq mRNA: 1 — MANE Select: NM_153444 NM_153444

CCDS: CCDS7782

Canonical transcript exons

ENST00000329434 — 1 exons

Exon	Start	End
ENSE00001324685	7795974	7796942

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 44.67.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	44.67	silver quality
skin of abdomen	UBERON:0001416	42.31	gold quality
zone of skin	UBERON:0000014	40.64	gold quality
bone marrow cell	CL:0002092	39.61	gold quality
skin of leg	UBERON:0001511	38.93	gold quality
tonsil	UBERON:0002372	38.84	gold quality
granulocyte	CL:0000094	37.25	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
urinary bladder	UBERON:0001255	33.62	silver quality
bone marrow	UBERON:0002371	33.50	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
right uterine tube	UBERON:0001302	33.22	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
fundus of stomach	UBERON:0001160	28.91	silver quality
liver	UBERON:0002107	28.84	gold quality
duodenum	UBERON:0002114	28.14	gold quality
leukocyte	CL:0000738	28.12	gold quality
right coronary artery	UBERON:0001625	27.66	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.61	gold quality
lymph node	UBERON:0000029	27.57	gold quality
descending thoracic aorta	UBERON:0002345	27.56	gold quality
monocyte	CL:0000576	27.54	gold quality
placenta	UBERON:0001987	27.51	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

44 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5p76	ENSMUSG00000058014
mus_musculus	Or5p78	ENSMUSG00000058244
mus_musculus	Or5p58	ENSMUSG00000059031
mus_musculus	Or5p79	ENSMUSG00000061000
mus_musculus	Or5p59	ENSMUSG00000078118
mus_musculus	Or5p68	ENSMUSG00000093980
mus_musculus	Or5p6	ENSMUSG00000094426
mus_musculus	Or5p72	ENSMUSG00000095239
mus_musculus	Or5p50	ENSMUSG00000095910
mus_musculus	Or5p63	ENSMUSG00000095929
mus_musculus	Or5p62	ENSMUSG00000096068
mus_musculus	Or5p81	ENSMUSG00000096209
mus_musculus	Or5p64	ENSMUSG00000096465
mus_musculus	Or5p73	ENSMUSG00000096679
mus_musculus	Or5p61	ENSMUSG00000108995
mus_musculus	Or5p67	ENSMUSG00000109497
mus_musculus	Or5p51	ENSMUSG00000109542
mus_musculus	Or5p69	ENSMUSG00000109631
mus_musculus	Or5p66	ENSMUSG00000109884
mus_musculus	Or5p60	ENSMUSG00000110171
mus_musculus	Or5p70	ENSMUSG00000110253
rattus_norvegicus	Or5p68	ENSRNOG00000009748
rattus_norvegicus	Or5p66	ENSRNOG00000009791
rattus_norvegicus	Or5p59	ENSRNOG00000028802
rattus_norvegicus	Or5p78	ENSRNOG00000034061
rattus_norvegicus	Or5p81	ENSRNOG00000055310
rattus_norvegicus	Or5p78c	ENSRNOG00000074162
rattus_norvegicus	Or5p60c	ENSRNOG00000075573
rattus_norvegicus	Or5p58	ENSRNOG00000075908
rattus_norvegicus	Or5p50	ENSRNOG00000076533
rattus_norvegicus	Or5p69	ENSRNOG00000078075
rattus_norvegicus	Or5p76b	ENSRNOG00000081021
rattus_norvegicus	Or5p60d	ENSRNOG00000081075
rattus_norvegicus		ENSRNOG00000081302
rattus_norvegicus	Or5p72	ENSRNOG00000081705
rattus_norvegicus	Or5p66b	ENSRNOG00000082853
rattus_norvegicus	Or5p78	ENSRNOG00000082952
rattus_norvegicus	Or5p60b	ENSRNOG00000083433
rattus_norvegicus	Or5p69b	ENSRNOG00000085928
rattus_norvegicus	Or5p79	ENSRNOG00000087465
rattus_norvegicus	Or5p6b	ENSRNOG00000087763
rattus_norvegicus	Or5p6	ENSRNOG00000090272
rattus_norvegicus	Or5p73	ENSRNOG00000090552
rattus_norvegicus	Or5p76	ENSRNOG00000090917

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5P2 — Q8WZ92 (reviewed: Q8WZ92)

Alternative names: Olfactory receptor-like protein JCG3

All UniProt accessions (2): Q8WZ92, A0A126GVJ7

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor (Potential). May be involved in taste perception.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in the tongue.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_703145* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, glycosylation site 2, sequence variant 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WZ92-F1	78.97	0.28

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 93–185

Glycosylation sites (2): 8, 259

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 22 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, CHEN_METABOLIC_SYNDROM_NETWORK, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_A, RAO_BOUND_BY_SALL4_ISOFORM_B

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

270 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5P2	ZBED11	P0CF97	477
OR5P2	F5GXT2	F5GXT2	447
OR5P2	GOLGA6L10	A6NI86	436
OR5P2	ANKRD45	Q5TZF3	397
OR5P2	C1orf198	Q9H425	395
OR5P2	ZNF99	A8MXY4	394
OR5P2	TEKT5	Q96M29	339
OR5P2	LRRC55	Q6ZSA7	324
OR5P2	H3BVE0	H3BVE0	321
OR5P2	VEPH1	Q14D04	313
OR5P2	BRINP2	Q9C0B6	311
OR5P2	KRT84	Q9NSB2	307
OR5P2	ATP10B	O94823	305
OR5P2	KRT85	P78386	300
OR5P2	KRT83	P78385	300

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A6NL26, O95221, P0C626, P0C7N1, P0C7N5, P0DMU2, P37070, P37071, P37072, Q13606, Q15617, Q26418, Q26419, Q60880, Q60882, Q60894, Q6IEU7, Q6IF36, Q6UXT6, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NGC0, Q8NGF4, Q8NGG0, Q8NGG1, Q8NGG2, Q8NGG3, Q8NGG5, Q8NGI9, Q8NGJ0, Q8NGL0, Q8NGL1, Q8NGM9, Q8NGP2, Q8NGP4, Q8NGP6, Q8NGP9, Q8NGQ1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

45 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

116 predictions. Top by Δscore:

Variant	Effect	Δscore
11:7796345:C:CT	acceptor_gain	0.9600
11:7796345:C:T	acceptor_gain	0.9400
11:7796346:A:T	acceptor_gain	0.8700
11:7796363:CAA:C	acceptor_gain	0.8300
11:7796720:G:GC	acceptor_gain	0.8300
11:7796366:C:CC	acceptor_gain	0.7300
11:7796713:A:C	acceptor_gain	0.7000
11:7796828:GATTA:G	donor_loss	0.6800
11:7796829:ATTAC:A	donor_loss	0.6800
11:7796830:TTACC:T	donor_loss	0.6800
11:7796831:TAC:T	donor_loss	0.6800
11:7796331:C:CT	acceptor_gain	0.6700
11:7796720:G:C	acceptor_gain	0.6600
11:7796827:AGATT:A	donor_loss	0.6600
11:7796374:ACACT:A	acceptor_gain	0.6000
11:7796536:A:AC	donor_gain	0.6000
11:7796537:C:CC	donor_gain	0.6000
11:7796832:A:AC	donor_gain	0.6000
11:7796833:C:CC	donor_gain	0.6000
11:7796712:CA:C	acceptor_gain	0.5900
11:7796765:T:TG	acceptor_gain	0.5900
11:7796713:A:AC	acceptor_gain	0.5700
11:7796716:T:TC	acceptor_gain	0.5600
11:7796535:G:T	donor_gain	0.5500
11:7796722:G:C	acceptor_gain	0.5400
11:7796767:A:T	acceptor_gain	0.5400
11:7796722:G:GC	acceptor_gain	0.5200
11:7796538:T:C	donor_gain	0.5100
11:7796376:ACTG:A	acceptor_gain	0.5000
11:7796766:C:CT	acceptor_gain	0.5000

AlphaMissense

2106 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:7796898:G:C	F15L	0.923
11:7796898:G:T	F15L	0.923
11:7796900:A:G	F15L	0.923
11:7796424:A:C	F173L	0.889
11:7796424:A:T	F173L	0.889
11:7796426:A:G	F173L	0.889
11:7796850:G:C	F31L	0.887
11:7796850:G:T	F31L	0.887
11:7796852:A:G	F31L	0.887
11:7796451:G:C	F164L	0.867
11:7796451:G:T	F164L	0.867
11:7796453:A:G	F164L	0.867
11:7796082:G:C	S287R	0.839
11:7796082:G:T	S287R	0.839
11:7796084:T:G	S287R	0.839
11:7796586:A:C	F119L	0.827
11:7796586:A:T	F119L	0.827
11:7796588:A:G	F119L	0.827
11:7796421:G:C	F174L	0.824
11:7796421:G:T	F174L	0.824
11:7796423:A:G	F174L	0.824
11:7796899:A:G	F15S	0.820
11:7796306:A:G	C213R	0.790
11:7796829:A:C	N38K	0.789
11:7796829:A:T	N38K	0.789
11:7796601:C:A	M114I	0.771
11:7796601:C:G	M114I	0.771
11:7796601:C:T	M114I	0.771
11:7796247:C:A	K232N	0.766
11:7796247:C:G	K232N	0.766

dbSNP variants (sampled 300 via entrez): RS1000374176 (11:7798195 G>A), RS1002428144 (11:7798572 C>T), RS1003968809 (11:7797255 A>C), RS1005527151 (11:7796186 A>C), RS1005862720 (11:7798667 A>G), RS1005933787 (11:7798749 C>T), RS1008747537 (11:7795490 G>T), RS1009614049 (11:7798096 T>C), RS1009650497 (11:7798548 C>A,G,T), RS1010616638 (11:7795775 C>A,G), RS1013335990 (11:7797174 T>A), RS1013638103 (11:7797438 A>G), RS1013971613 (11:7798717 G>A,C), RS1015610106 (11:7798776 G>A,T), RS1015909653 (11:7798682 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST010397_59	Gut microbiota (bacterial taxa, rank normal transformation method)	4.000000e-06
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
arsenite	decreases methylation	1
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Asbestos, Crocidolite	affects expression	1
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.