OR5P3

Summary

OR5P3 (olfactory receptor family 5 subfamily P member 3, HGNC:14784) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 5P3 (Q8WZ94). Odorant receptor (Potential).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 120066 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 50 total
• MANE Select transcript: NM_153445

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14784
Approved symbol	OR5P3
Name	olfactory receptor family 5 subfamily P member 3
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	JCG1
Ensembl gene	ENSG00000182334
Ensembl biotype	protein_coding
Entrez	120066

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641167

RefSeq mRNA: 1 — MANE Select: NM_153445 NM_153445

CCDS: CCDS7783

Canonical transcript exons

ENST00000619725 — 0 exons

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 41.46.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of abdomen	UBERON:0001416	41.46	gold quality
zone of skin	UBERON:0000014	40.40	gold quality
tonsil	UBERON:0002372	40.27	gold quality
skin of leg	UBERON:0001511	39.02	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
urinary bladder	UBERON:0001255	33.26	silver quality
muscle tissue	UBERON:0002385	32.32	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
right uterine tube	UBERON:0001302	30.25	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
thoracic mammary gland	UBERON:0005200	28.79	silver quality
duodenum	UBERON:0002114	28.14	gold quality
monocyte	CL:0000576	28.06	gold quality
liver	UBERON:0002107	28.04	gold quality
leukocyte	CL:0000738	28.02	gold quality
placenta	UBERON:0001987	27.69	gold quality
lymph node	UBERON:0000029	27.57	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.31	gold quality
right lung	UBERON:0002167	26.17	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5p57	ENSMUSG00000063120
mus_musculus	Or5p80	ENSMUSG00000063764
rattus_norvegicus	Or5p80	ENSRNOG00000081541
rattus_norvegicus		ENSRNOG00000090212

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5P3 — Q8WZ94 (reviewed: Q8WZ94)

Alternative names: Olfactory receptor OR11-94, Olfactory receptor-like protein JCG1

All UniProt accessions (2): Q8WZ94, A0A126GVE6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor (Potential). May be involved in taste perception.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in the tongue.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_703146* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WZ94-F1	87.00	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 28 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, SUPT16H_TARGET_GENES, GSE17721_CTRL_VS_LPS_0.5H_BMDC_DN, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

242 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5P3	ZNF835	Q9Y2P0	447
OR5P3	JHY	Q6NUN7	419
OR5P3	MOGAT3	Q86VF5	400
OR5P3	TAS2R38	P59533	394
OR5P3	GNG8	Q9UK08	371
OR5P3	BTBD10	Q9BSF8	365
OR5P3	CHRM4	P08173	353
OR5P3	HOMEZ	Q8IX15	352
OR5P3	CHRM1	P11229	351
OR5P3	UXS1	Q8NBZ7	321
OR5P3	B4GALNT3	Q6L9W6	313
OR5P3	GNAL	P38405	311
OR5P3	CNGA2	Q16280	310
OR5P3	TAS2R14	Q9NYV8	305
OR5P3	ANO2	Q9NQ90	302

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NL26, O14581, O76100, O95006, P34986, P37068, P37070, P37071, P58173, Q5TZ20, Q60890, Q60893, Q6IEU7, Q8N146, Q8NGA1, Q8NGE9, Q8NGG1, Q8NGG4, Q8NGI9, Q8NGL2, Q8NGP8, Q8NGQ1, Q8NGQ6, Q8NGS0, Q8NGZ4, Q8NGZ9, Q8NH01, Q8NH04, Q8NHC8, Q8VEW5, Q8VEZ0, Q8VF65, Q8VF66, Q8VF76, Q8VFD2, Q8VFL9, Q8VFM9, Q8VFX2, Q8VG02, Q8VG05

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P58180, Q13606, Q15615, Q60878, Q60881, Q60888, Q60893, Q6IEV9, Q6IEY1, Q6IF82, Q6UXT6, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8NGA1, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD3, Q8NGD4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

50 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

178 predictions. Top by Δscore:

Variant	Effect	Δscore
11:7825711:T:A	donor_gain	0.8000
11:7825535:G:A	donor_gain	0.6800
11:7825945:C:CT	donor_gain	0.6700
11:7825433:G:C	donor_gain	0.6300
11:7825941:TC:T	donor_gain	0.5700
11:7825216:CA:C	acceptor_gain	0.5300
11:7825363:C:CT	acceptor_gain	0.5300
11:7825847:A:AC	donor_gain	0.5300
11:7825905:A:AC	donor_gain	0.5300
11:7825906:C:CC	donor_gain	0.5300
11:7825517:TCC:T	donor_gain	0.5200
11:7825082:AATCT:A	donor_gain	0.5000
11:7825196:A:C	acceptor_gain	0.5000
11:7825797:A:C	donor_gain	0.5000
11:7825093:T:A	donor_gain	0.4900
11:7825374:GCTGG:G	acceptor_loss	0.4900
11:7825375:CTGG:C	acceptor_loss	0.4900
11:7825376:T:A	acceptor_loss	0.4800
11:7825910:AGTAT:A	donor_gain	0.4800
11:7825942:C:CT	donor_gain	0.4700
11:7825943:T:TT	donor_gain	0.4700
11:7825185:T:C	acceptor_gain	0.4600
11:7825215:CCA:C	acceptor_gain	0.4600
11:7825363:C:T	acceptor_gain	0.4600
11:7825539:A:AC	donor_gain	0.4600
11:7825540:C:CC	donor_gain	0.4600
11:7825132:C:CT	donor_gain	0.4400
11:7825375:C:CC	acceptor_gain	0.4400
11:7825388:A:T	acceptor_gain	0.4400
11:7825370:GATAG:G	acceptor_gain	0.4300

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000133675 (11:7829642 C>T), RS1000263835 (11:7824413 A>C), RS1000507101 (11:7829265 A>G), RS1000535663 (11:7826850 AT>A), RS1001272451 (11:7829693 G>A), RS1001305064 (11:7829956 A>C), RS1001483469 (11:7824690 T>C), RS1001633525 (11:7829894 T>C), RS1001855568 (11:7824470 G>A,C), RS1002692290 (11:7828679 G>C), RS1002939736 (11:7830936 C>A), RS1003307700 (11:7832383 T>C), RS1003487261 (11:7827126 A>T), RS1003864062 (11:7826881 A>C), RS1004519866 (11:7824732 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Acetaminophen	increases expression	1
Ethanol	affects cotreatment, increases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Folic Acid	affects cotreatment, increases expression	1
Oxygen	increases expression	1
Aflatoxin B1	decreases methylation	1
Asbestos, Crocidolite	affects expression	1
Cadmium Chloride	increases abundance, increases expression	1
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.