OR5T1

Summary

OR5T1 (olfactory receptor family 5 subfamily T member 1, HGNC:14821) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5T1 (Q8NG75). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390155 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 68 total
• MANE Select transcript: NM_001004745

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14821
Approved symbol	OR5T1
Name	olfactory receptor family 5 subfamily T member 1
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181698
Ensembl biotype	protein_coding
Entrez	390155

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641665

RefSeq mRNA: 1 — MANE Select: NM_001004745 NM_001004745

CCDS: CCDS31525

Canonical transcript exons

ENST00000576733 — 0 exons

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.66	gold quality
leukocyte	CL:0000738	29.47	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.60	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.92	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.13	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.93	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.26	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
frontal cortex	UBERON:0001870	23.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
danio_rerio	adra1ab	ENSDARG00000027638
mus_musculus	Or5t9	ENSMUSG00000044213
mus_musculus	Or5t5	ENSMUSG00000047969
mus_musculus	Or5t17	ENSMUSG00000049843
rattus_norvegicus	Or5t5b	ENSRNOG00000072236
rattus_norvegicus		ENSRNOG00000089058
rattus_norvegicus	Or5t9b	ENSRNOG00000089597
rattus_norvegicus	Or5t5	ENSRNOG00000091197
caenorhabditis_elegans	ser-5	WBGENE00008890

Paralogs (18): ADRB1 (ENSG00000043591), ADRA1A (ENSG00000120907), DRD2 (ENSG00000149295), ADRA2A (ENSG00000150594), GPR101 (ENSG00000165370), ADRB2 (ENSG00000169252), ADRA1B (ENSG00000170214), ADRA1D (ENSG00000171873), OR5T3 (ENSG00000172489), OR56A1 (ENSG00000180934), OR5T2 (ENSG00000181718), OR56A4 (ENSG00000183389), ADRA2C (ENSG00000184160), OR56A3 (ENSG00000184478), OR13F1 (ENSG00000186881), OR56A5 (ENSG00000188691), ADRB3 (ENSG00000188778), ADRA2B (ENSG00000274286)

Protein

Protein identifiers

Olfactory receptor 5T1 — Q8NG75 (reviewed: Q8NG75)

Alternative names: Olfactory receptor OR11-179

All UniProt accessions (2): A0A126GVL6, Q8NG75

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004745* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NG75-F1	86.99	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 17, 101

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, CAMPS_COLON_CANCER_COPY_NUMBER_UP, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, FIGUEROA_AML_METHYLATION_CLUSTER_6_DN, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

254 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5T1	ZC2HC1C	Q53FD0	571
OR5T1	VWA3A	A6NCI4	479
OR5T1	MIER2	Q8N344	449
OR5T1	ZNF721	Q8TF20	446
OR5T1	CCDC32	Q9BV29	431
OR5T1	THSD1	Q9NS62	368
OR5T1	ENOSF1	Q7L5Y1	359
OR5T1	NEXMIF	Q5QGS0	348
OR5T1	IGFN1	Q86VF2	348
OR5T1	PDE6G	P18545	323
OR5T1	ZFYVE16	Q7Z3T8	323
OR5T1	CPSF7	Q8N684	317
OR5T1	TENM1	Q9UKZ4	291
OR5T1	TENM3	Q9P273	280
OR5T1	TTC3	P78477	277

IntAct

0 interactions, top by confidence:

BioGRID (1): OR5T1 (Affinity Capture-Luminescence)

ESM2 similar proteins: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NM76, P0C617, P0C628, P34983, P37067, P37069, P37070, Q13606, Q60884, Q60886, Q7TR96, Q8N127, Q8N162, Q8NG75, Q8NGE1, Q8NGE2, Q8NGF7, Q8NGG5, Q8NGI8, Q8NGL1, Q8NGL4, Q8NGQ3, Q8NGS5, Q8NGV7, Q8NH51, Q8NH92, Q8NH93, Q8VEW2, Q8VEW6, Q8VEX6, Q8VF12, Q8VF66, Q8VFB9, Q8VFD0, Q8VFD1

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

68 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	67
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

254 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56276282:T:TA	acceptor_gain	0.8200
11:56276339:T:TA	acceptor_gain	0.7900
11:56276283:G:A	acceptor_gain	0.7800
11:56276328:T:TA	acceptor_gain	0.7600
11:56276342:T:A	acceptor_gain	0.7500
11:56276327:AT:A	acceptor_gain	0.6900
11:56276335:ATTCT:A	acceptor_gain	0.6800
11:56276351:T:TA	acceptor_gain	0.6800
11:56276354:A:AG	acceptor_gain	0.6700
11:56276355:G:GG	acceptor_gain	0.6700
11:56276335:A:AG	acceptor_gain	0.6500
11:56276355:GAT:G	acceptor_gain	0.6500
11:56276342:T:TA	acceptor_loss	0.6400
11:56276353:AAGAT:A	acceptor_loss	0.6400
11:56276355:G:A	acceptor_loss	0.6400
11:56276328:T:G	acceptor_gain	0.6300
11:56276293:G:GC	acceptor_gain	0.6200
11:56276343:G:A	acceptor_gain	0.6000
11:56276253:C:G	acceptor_gain	0.5900
11:56276244:T:TA	acceptor_gain	0.5800
11:56276347:A:AG	acceptor_gain	0.5700
11:56275742:TGC:T	donor_gain	0.5600
11:56276336:T:G	acceptor_gain	0.5500
11:56276347:ATTCT:A	acceptor_gain	0.5500
11:56276348:T:G	acceptor_gain	0.5500
11:56276355:GATGC:G	acceptor_gain	0.5500
11:56276451:T:G	acceptor_gain	0.5400
11:56276213:A:AG	donor_gain	0.5300
11:56276290:ATT:A	acceptor_gain	0.5300
11:56275696:G:GT	donor_gain	0.5200

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000246014 (11:56277225 A>C,T), RS1000423141 (11:56276951 A>G), RS1000882775 (11:56272884 G>A), RS1002194934 (11:56272291 A>G), RS1003800630 (11:56274791 A>C), RS1004054794 (11:56276024 C>A,T), RS1004201416 (11:56275121 G>T), RS1004341912 (11:56274940 T>C), RS1006016327 (11:56273406 A>G), RS1006202992 (11:56275519 C>A,T), RS1006930363 (11:56272491 T>G), RS1006985852 (11:56272731 A>C), RS1007385345 (11:56273258 T>C), RS1007432610 (11:56272929 G>A), RS1007884790 (11:56276110 A>C,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Fulvestrant	decreases methylation	1
Benzo(a)pyrene	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.