OR5T2

Summary

OR5T2 (olfactory receptor family 5 subfamily T member 2, HGNC:15296) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5T2 (Q8NGG2). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219464 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 74 total
• MANE Select transcript: NM_001004746

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15296
Approved symbol	OR5T2
Name	olfactory receptor family 5 subfamily T member 2
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181718
Ensembl biotype	protein_coding
Entrez	219464

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641661

RefSeq mRNA: 1 — MANE Select: NM_001004746 NM_001004746

CCDS: CCDS31523

Canonical transcript exons

ENST00000573647 — 0 exons

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 49.18.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	49.18	gold quality
calcaneal tendon	UBERON:0003701	43.72	gold quality
granulocyte	CL:0000094	42.32	silver quality
sural nerve	UBERON:0015488	41.48	gold quality
ventricular zone	UBERON:0003053	40.10	gold quality
lower esophagus mucosa	UBERON:0035834	37.75	gold quality
bone marrow	UBERON:0002371	37.46	gold quality
ganglionic eminence	UBERON:0004023	37.27	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
endometrium	UBERON:0001295	36.78	silver quality
cortical plate	UBERON:0005343	36.47	gold quality
mucosa of transverse colon	UBERON:0004991	36.23	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
corpus callosum	UBERON:0002336	35.00	gold quality
skeletal muscle tissue	UBERON:0001134	34.77	gold quality
muscle tissue	UBERON:0002385	33.21	gold quality
muscle of leg	UBERON:0001383	32.71	gold quality
leukocyte	CL:0000738	32.65	gold quality
lymph node	UBERON:0000029	32.39	gold quality
monocyte	CL:0000576	32.32	gold quality
mucosa of stomach	UBERON:0001199	32.31	gold quality
vermiform appendix	UBERON:0001154	32.23	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
tonsil	UBERON:0002372	32.07	gold quality
urinary bladder	UBERON:0001255	31.96	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	31.82	gold quality
liver	UBERON:0002107	31.31	gold quality
gastrocnemius	UBERON:0001388	31.28	gold quality
cerebellar hemisphere	UBERON:0002245	30.82	gold quality
cerebellar cortex	UBERON:0002129	30.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

10 orthologs

Organism	Symbol	Gene ID
danio_rerio	adra1ab	ENSDARG00000027638
mus_musculus	Or5t16	ENSMUSG00000075167
mus_musculus	Or5t15	ENSMUSG00000075171
mus_musculus	Or5t7	ENSMUSG00000075175
mus_musculus	Or5t18	ENSMUSG00000078420
rattus_norvegicus	Or5t16	ENSRNOG00000030825
rattus_norvegicus	Olr520	ENSRNOG00000049954
rattus_norvegicus	Or5t7	ENSRNOG00000052014
rattus_norvegicus	Olr520	ENSRNOG00000073927
caenorhabditis_elegans	ser-5	WBGENE00008890

Paralogs (18): ADRB1 (ENSG00000043591), ADRA1A (ENSG00000120907), DRD2 (ENSG00000149295), ADRA2A (ENSG00000150594), GPR101 (ENSG00000165370), ADRB2 (ENSG00000169252), ADRA1B (ENSG00000170214), ADRA1D (ENSG00000171873), OR5T3 (ENSG00000172489), OR56A1 (ENSG00000180934), OR5T1 (ENSG00000181698), OR56A4 (ENSG00000183389), ADRA2C (ENSG00000184160), OR56A3 (ENSG00000184478), OR13F1 (ENSG00000186881), OR56A5 (ENSG00000188691), ADRB3 (ENSG00000188778), ADRA2B (ENSG00000274286)

Protein

Protein identifiers

Olfactory receptor 5T2 — Q8NGG2 (reviewed: Q8NGG2)

Alternative names: Olfactory receptor OR11-177

All UniProt accessions (1): A0A286YF86

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004746* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 6, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGG2-F1	80.40	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 44

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

154 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5T2	TRIM48	Q8IWZ4	447
OR5T2	FRMPD3	Q5JV73	445
OR5T2	TRIM51	Q9BSJ1	435
OR5T2	UTP20	O75691	371
OR5T2	CMYA5	Q8N3K9	333
OR5T2	ZNF737	O75373	325
OR5T2	ARL15	Q9NXU5	325
OR5T2	MYADM	Q96S97	312
OR5T2	KRTAP9-1	A8MXZ3	311
OR5T2	NDNF	Q8TB73	306
OR5T2	CFAP47	Q6ZTR5	265
OR5T2	KRTAP9-2	Q9BYQ4	258
OR5T2	LAPTM5	Q13571	257
OR5T2	POTEM	A6NI47	257
OR5T2	VWA3B	Q502W6	247

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A6NDH6, A6NET4, A6NHG9, A6NKK0, A6NL26, A6NMS3, O95221, P0C626, P0C628, P0C7N1, P0C7N5, P0DMU2, P0DN80, P34985, P37068, P37070, P37071, P37072, Q13606, Q15617, Q15620, Q60880, Q60882, Q60884, Q60886, Q60893, Q60894, Q6UXT6, Q7TS48, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NG78, Q8NGC0, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

74 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	68
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

302 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56232403:C:CT	acceptor_gain	0.8500
11:56232410:A:T	acceptor_gain	0.8500
11:56232409:C:CT	acceptor_gain	0.8100
11:56232460:C:CT	acceptor_gain	0.8100
11:56232415:A:T	acceptor_gain	0.8000
11:56232404:A:T	acceptor_gain	0.7800
11:56232414:CA:C	acceptor_gain	0.7800
11:56232486:T:C	acceptor_gain	0.7700
11:56232460:C:T	acceptor_gain	0.7600
11:56232400:C:T	acceptor_gain	0.7500
11:56232415:A:AC	acceptor_gain	0.7400
11:56232400:C:CT	acceptor_gain	0.7300
11:56232415:A:C	acceptor_gain	0.7300
11:56232401:A:T	acceptor_gain	0.7100
11:56232488:G:GC	acceptor_gain	0.7100
11:56232385:CAT:C	acceptor_gain	0.7000
11:56232391:C:CT	acceptor_gain	0.7000
11:56232392:A:T	acceptor_gain	0.6800
11:56232215:A:T	acceptor_gain	0.6700
11:56232499:A:T	acceptor_gain	0.6700
11:56232462:CAAAG:C	acceptor_gain	0.6600
11:56232486:T:TC	acceptor_gain	0.6500
11:56232395:A:AC	acceptor_gain	0.6200
11:56232383:TACAT:T	acceptor_gain	0.6100
11:56232388:C:CC	acceptor_gain	0.6100
11:56232413:CCA:C	acceptor_gain	0.6100
11:56232466:G:GC	acceptor_gain	0.6000
11:56232488:G:C	acceptor_gain	0.6000
11:56232498:C:CT	acceptor_gain	0.6000
11:56232466:G:C	acceptor_gain	0.5900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000334622 (11:56233449 A>G), RS1000399375 (11:56234110 T>C), RS1000784386 (11:56233701 T>C), RS1001400386 (11:56235418 T>C), RS1001800007 (11:56235195 C>A,T), RS1002334145 (11:56234035 C>T), RS1003188194 (11:56230988 C>T), RS1003219342 (11:56231232 A>C,G,T), RS1003944701 (11:56230889 C>T), RS1004230834 (11:56231122 C>T), RS1004477095 (11:56236237 A>G), RS1004490364 (11:56231490 C>A,T), RS1005845239 (11:56235333 G>A), RS1007377850 (11:56234589 A>C,T), RS1007460833 (11:56234606 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST005580_59	Intraocular pressure	3.000000e-12
GCST007637_51	Diffusing capacity of carbon monoxide	6.000000e-06
GCST010241_129	Apolipoprotein A1 levels	3.000000e-24

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement
EFO:0009369	diffusing capacity of the lung for carbon monoxide
EFO:0004614	apolipoprotein A 1 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol F	affects cotreatment, decreases methylation	1
2-butenal	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Benzo(a)pyrene	affects methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	affects expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.