OR5T3

Summary

OR5T3 (olfactory receptor family 5 subfamily T member 3, HGNC:15297) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5T3 (Q8NGG3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390154 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 59 total
• MANE Select transcript: NM_001004747

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15297
Approved symbol	OR5T3
Name	olfactory receptor family 5 subfamily T member 3
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	OR5T3Q
Ensembl gene	ENSG00000172489
Ensembl biotype	protein_coding
Entrez	390154

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000313033

RefSeq mRNA: 1 — MANE Select: NM_001004747 NM_001004747

CCDS: CCDS31524

Canonical transcript exons

ENST00000313033 — 1 exons

Exon	Start	End
ENSE00001270439	56252254	56253222

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 81.44.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.44	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
urinary bladder	UBERON:0001255	28.29	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.02	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
leukocyte	CL:0000738	24.80	gold quality
pancreas	UBERON:0001264	24.76	gold quality
muscle of leg	UBERON:0001383	24.74	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
monocyte	CL:0000576	24.52	gold quality
uterine cervix	UBERON:0000002	24.43	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
danio_rerio	adra1ab	ENSDARG00000027638
mus_musculus	Or5t9	ENSMUSG00000044213
mus_musculus	Or5t5	ENSMUSG00000047969
mus_musculus	Or5t17	ENSMUSG00000049843
rattus_norvegicus	Or5t5b	ENSRNOG00000072236
rattus_norvegicus		ENSRNOG00000089058
rattus_norvegicus	Or5t9b	ENSRNOG00000089597
rattus_norvegicus	Or5t5	ENSRNOG00000091197
caenorhabditis_elegans	ser-5	WBGENE00008890

Paralogs (18): ADRB1 (ENSG00000043591), ADRA1A (ENSG00000120907), DRD2 (ENSG00000149295), ADRA2A (ENSG00000150594), GPR101 (ENSG00000165370), ADRB2 (ENSG00000169252), ADRA1B (ENSG00000170214), ADRA1D (ENSG00000171873), OR56A1 (ENSG00000180934), OR5T1 (ENSG00000181698), OR5T2 (ENSG00000181718), OR56A4 (ENSG00000183389), ADRA2C (ENSG00000184160), OR56A3 (ENSG00000184478), OR13F1 (ENSG00000186881), OR56A5 (ENSG00000188691), ADRB3 (ENSG00000188778), ADRA2B (ENSG00000274286)

Protein

Protein identifiers

Olfactory receptor 5T3 — Q8NGG3 (reviewed: Q8NGG3)

Alternative names: Olfactory receptor OR11-178

All UniProt accessions (1): A0A2C9F2M2

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004747* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGG3-F1	85.54	0.52

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 127–219

Glycosylation sites (2): 35, 119

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, CAMPS_COLON_CANCER_COPY_NUMBER_UP, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

44 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5T3	B3GNT8	Q7Z7M8	187
OR5T3	PTCRA	Q6ISU1	182
OR5T3	CD72	P21854	164
OR5T3	SUGP2	Q8IX01	164
OR5T3	HAUS3	Q68CZ6	73
OR5T3	ARRB2	P32121	56
OR5T3	ARRB1	P49407	56
OR5T3	PRKACA	P17612	42
OR5T3	PRKACG	P22612	42
OR5T3	PRKACB	P22694	42
OR5T3	GRK2	P25098	42
OR5T3	GRK3	P35626	42
OR5T3	FGF23	Q9GZV9	0
OR5T3	GNG13	Q9P2W3	0
OR5T3	OR6C74	A6NCV1	0
OR5T3	GNG7	O60262	0
OR5T3	GNB1	P04697	0
OR5T3	GNAL	P38405	0

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

59 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	56
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

201 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56252966:T:TA	acceptor_gain	0.8200
11:56252954:T:A	acceptor_gain	0.8000
11:56252950:A:AG	acceptor_gain	0.7600
11:56252950:ATTCT:A	acceptor_gain	0.7600
11:56252957:T:TA	acceptor_gain	0.7500
11:56252943:T:TA	acceptor_gain	0.7300
11:56252963:T:G	acceptor_gain	0.7200
11:56252951:T:G	acceptor_gain	0.7100
11:56252908:G:GC	acceptor_gain	0.7000
11:56252962:ATTCT:A	acceptor_gain	0.7000
11:56252311:G:GT	donor_gain	0.6900
11:56252898:G:A	acceptor_gain	0.6900
11:56252941:T:A	acceptor_gain	0.6800
11:56252962:A:AG	acceptor_gain	0.6800
11:56252969:A:AG	acceptor_gain	0.6800
11:56252970:G:GG	acceptor_gain	0.6800
11:56252970:GATGC:G	acceptor_gain	0.6700
11:56252970:GAT:G	acceptor_gain	0.6500
11:56252969:AGAT:A	acceptor_gain	0.6400
11:56252970:GATG:G	acceptor_gain	0.6400
11:56252897:T:TA	acceptor_gain	0.6200
11:56252954:T:TA	acceptor_loss	0.6100
11:56252966:TGAA:T	acceptor_loss	0.6100
11:56252967:GAA:G	acceptor_loss	0.6100
11:56252969:A:AT	acceptor_loss	0.6100
11:56252987:G:GT	donor_gain	0.6100
11:56252355:GCT:G	donor_gain	0.6000
11:56252863:A:AG	acceptor_gain	0.6000
11:56252957:T:A	acceptor_loss	0.6000
11:56252315:TCACC:T	donor_gain	0.5900

AlphaMissense

2114 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56252791:T:C	F198L	0.855
11:56252793:C:A	F198L	0.855
11:56252793:C:G	F198L	0.855
11:56252779:T:C	F194L	0.827
11:56252781:T:A	F194L	0.827
11:56252781:T:G	F194L	0.827
11:56252323:T:C	F42L	0.804
11:56252325:T:A	F42L	0.804
11:56252325:T:G	F42L	0.804
11:56252821:T:C	F208L	0.769
11:56252823:T:A	F208L	0.769
11:56252823:T:G	F208L	0.769
11:56252371:T:C	F58L	0.617
11:56252373:T:A	F58L	0.617
11:56252373:T:G	F58L	0.617
11:56252324:T:C	F42S	0.613
11:56252380:T:C	F61L	0.578
11:56252382:T:A	F61L	0.578
11:56252382:T:G	F61L	0.578
11:56253001:T:C	F268L	0.568
11:56253003:C:A	F268L	0.568
11:56253003:C:G	F268L	0.568

dbSNP variants (sampled 300 via entrez): RS1001649979 (11:56250382 G>A,C), RS1002647835 (11:56251593 C>A,T), RS1002698673 (11:56251950 G>A), RS1003991488 (11:56252112 T>C,G), RS1004083509 (11:56250339 G>A,T), RS1005094081 (11:56251606 A>C), RS1006065408 (11:56251222 A>G), RS1006117853 (11:56251488 T>C), RS1008175753 (11:56250883 A>C,G), RS1008279226 (11:56253716 T>C), RS1008417692 (11:56251013 CCCTCTAATTTTA>C), RS1008776616 (11:56253253 A>G), RS1009504978 (11:56252542 T>C), RS1011176584 (11:56250882 C>G,T), RS1011228678 (11:56251305 T>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001762_844	Obesity-related traits	9.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004574	total cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
MT19c compound	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	decreases expression, increases abundance	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.