OR5W2

Summary

OR5W2 (olfactory receptor family 5 subfamily W member 2, HGNC:15299) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 5W2 (Q8NH69). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390148 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 47 total
• MANE Select transcript: NM_001001960

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15299
Approved symbol	OR5W2
Name	olfactory receptor family 5 subfamily W member 2
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000187612
Ensembl biotype	protein_coding
Entrez	390148

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000344514

RefSeq mRNA: 1 — MANE Select: NM_001001960 NM_001001960

CCDS: CCDS31513

Canonical transcript exons

ENST00000344514 — 1 exons

Exon	Start	End
ENSE00001271651	55913650	55914582

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 94.91.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.91	silver quality
colonic epithelium	UBERON:0000397	46.66	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.24	silver quality
leukocyte	CL:0000738	29.09	silver quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.34	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.06	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	24.94	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.16	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.96

Regulation

Is transcription factor: no

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or5w8	ENSMUSG00000047039
mus_musculus	Or8w1	ENSMUSG00000068818
rattus_norvegicus	Or5w8	ENSRNOG00000069914
rattus_norvegicus	Or5w8b	ENSRNOG00000078814
rattus_norvegicus	Or8w1b	ENSRNOG00000081422
rattus_norvegicus	Or8w1	ENSRNOG00000087274

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 5W2 — Q8NH69 (reviewed: Q8NH69)

Alternative names: Olfactory receptor 5W3, Olfactory receptor OR11-155

All UniProt accessions (1): Q8NH69

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001960* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (24 total): topological domain 8, transmembrane region 7, sequence variant 7, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH69-F1	90.89	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_B, RAO_BOUND_BY_SALL4, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

240 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR5W2	C11orf87	Q6NUJ2	507
OR5W2	CCT8L2	Q96SF2	479
OR5W2	ZNF99	A8MXY4	430
OR5W2	TRIM48	Q8IWZ4	417
OR5W2	TRIM51	Q9BSJ1	396
OR5W2	LRRC55	Q6ZSA7	369
OR5W2	LCE3A	Q5TA76	325
OR5W2	ZIM2	Q9NZV7	311
OR5W2	LRFN5	Q96NI6	305
OR5W2	ZNF737	O75373	297
OR5W2	ADAM29	Q9UKF5	290
OR5W2	SEMG1	P04279	273
OR5W2	DOK5	Q9P104	270
OR5W2	PSG8	Q9UQ74	259
OR5W2	KEL	P23276	247
OR5W2	NLRP5	P59047	247

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NCV1, O95221, P0C7N1, P0C7N5, Q60881, Q60888, Q6IEU7, Q8NGA8, Q8NGB6, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD4, Q8NGD5, Q8NGE8, Q8NGF8, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGM9, Q8NGP8, Q8NGP9, Q8NGS9, Q8NGT0, Q8NH01, Q8NH10, Q8NH18, Q8NH21, Q8NH41, Q8NH42, Q8NH43, Q8NH49, Q8NH69, Q8NH85, Q8VEW5, Q8VF65, Q8VFD3

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

454 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55914513:T:A	donor_gain	0.8400
11:55914536:C:A	donor_gain	0.8400
11:55914373:A:AC	donor_gain	0.8200
11:55914535:T:TA	donor_gain	0.8100
11:55914572:T:A	donor_gain	0.7200
11:55914506:G:GC	donor_gain	0.7000
11:55914509:A:AC	donor_gain	0.7000
11:55914510:C:CC	donor_gain	0.7000
11:55913876:TTGA:T	donor_gain	0.6900
11:55914269:CAGA:C	donor_gain	0.6800
11:55914270:AGAA:A	donor_gain	0.6800
11:55914271:GAAG:G	donor_gain	0.6800
11:55914272:AAGA:A	donor_gain	0.6800
11:55914573:C:A	donor_gain	0.6800
11:55914311:G:T	donor_gain	0.6700
11:55914495:CAG:C	donor_gain	0.6700
11:55914511:T:C	donor_gain	0.6700
11:55914392:C:CC	acceptor_gain	0.6600
11:55913740:C:CT	acceptor_gain	0.6500
11:55914485:G:GA	donor_gain	0.6500
11:55914314:T:C	donor_gain	0.6300
11:55914494:A:AC	donor_gain	0.6300
11:55914495:C:CC	donor_gain	0.6300
11:55914312:A:AC	donor_gain	0.6100
11:55914313:C:CC	donor_gain	0.6100
11:55914309:T:C	donor_gain	0.6000
11:55914451:T:TA	donor_gain	0.6000
11:55913910:C:CC	acceptor_gain	0.5900
11:55914333:C:CT	donor_gain	0.5900
11:55914334:T:TT	donor_gain	0.5900

AlphaMissense

2029 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55914052:G:C	F177L	0.837
11:55914052:G:T	F177L	0.837
11:55914054:A:G	F177L	0.837
11:55914369:A:G	C72R	0.828
11:55914079:G:C	F168L	0.823
11:55914079:G:T	F168L	0.823
11:55914081:A:G	F168L	0.823
11:55913710:G:C	S291R	0.821
11:55913710:G:T	S291R	0.821
11:55913712:T:G	S291R	0.821
11:55914091:G:C	F164L	0.788
11:55914091:G:T	F164L	0.788
11:55914093:A:G	F164L	0.788
11:55913875:T:A	K236N	0.784
11:55913875:T:G	K236N	0.784
11:55914229:C:A	M118I	0.777
11:55914229:C:G	M118I	0.777
11:55914229:C:T	M118I	0.777
11:55913830:G:C	F251L	0.774
11:55913830:G:T	F251L	0.774
11:55913832:A:G	F251L	0.774
11:55914547:A:C	F12L	0.768
11:55914547:A:T	F12L	0.768
11:55914549:A:G	F12L	0.768
11:55914049:G:C	F178L	0.766
11:55914049:G:T	F178L	0.766
11:55914051:A:G	F178L	0.766
11:55914218:C:G	R122P	0.762
11:55913752:A:C	F277L	0.759
11:55913752:A:T	F277L	0.759

dbSNP variants (sampled 300 via entrez): RS1000550645 (11:55915660 G>A), RS1000604437 (11:55915982 C>T), RS1001406729 (11:55916550 G>C), RS1003015023 (11:55914787 C>A,T), RS1003047487 (11:55914998 A>G), RS1003929451 (11:55914138 A>G), RS1004171103 (11:55914704 A>T), RS1005886087 (11:55913371 T>A,C,G), RS1009299015 (11:55915101 T>C), RS1012127796 (11:55915291 C>T), RS1013156140 (11:55914730 T>C), RS1015473794 (11:55915815 A>T), RS1016868483 (11:55914999 T>C,G), RS1017611661 (11:55914453 C>A,T), RS1019804994 (11:55913204 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010988_418	Adult body size	3.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases methylation	1
bisphenol S	affects cotreatment, decreases methylation	1
Fulvestrant	decreases methylation, affects cotreatment	1
Arsenic	affects methylation	1
Benzo(a)pyrene	decreases methylation, increases methylation	1
Sodium Selenite	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.