OR6A2

Summary

OR6A2 (olfactory receptor family 6 subfamily A member 2, HGNC:15301) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 6A2 (O95222). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 8590 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_003696

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15301
Approved symbol	OR6A2
Name	olfactory receptor family 6 subfamily A member 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	OR11-55
Ensembl gene	ENSG00000184933
Ensembl biotype	protein_coding
OMIM	608495
Entrez	8590

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641196

RefSeq mRNA: 1 — MANE Select: NM_003696 NM_003696

CCDS: CCDS7772

Canonical transcript exons

ENST00000641196 — 2 exons

Exon	Start	End
ENSE00003812698	6791736	6795884
ENSE00003813717	6799544	6799689

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 83.10.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.10	gold quality
bone marrow cell	CL:0002092	59.51	silver quality
sural nerve	UBERON:0015488	47.26	gold quality
bone marrow	UBERON:0002371	44.98	silver quality
calcaneal tendon	UBERON:0003701	41.46	gold quality
colonic epithelium	UBERON:0000397	41.16	gold quality
primary visual cortex	UBERON:0002436	39.15	gold quality
superior frontal gyrus	UBERON:0002661	38.30	gold quality
tonsil	UBERON:0002372	38.19	gold quality
ganglionic eminence	UBERON:0004023	37.14	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
skeletal muscle tissue	UBERON:0001134	34.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	33.71	gold quality
lymph node	UBERON:0000029	33.70	gold quality
uterine cervix	UBERON:0000002	33.23	gold quality
monocyte	CL:0000576	33.10	gold quality
leukocyte	CL:0000738	32.61	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	32.06	gold quality
adrenal tissue	UBERON:0018303	31.99	gold quality
urinary bladder	UBERON:0001255	31.84	gold quality
endometrium	UBERON:0001295	31.72	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	31.24	gold quality
liver	UBERON:0002107	30.95	gold quality
endocervix	UBERON:0000458	30.81	gold quality
putamen	UBERON:0001874	30.66	gold quality
ectocervix	UBERON:0012249	30.24	gold quality
body of uterus	UBERON:0009853	30.19	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.25

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): LHX2

miRNA regulators (miRDB)

11 targeting OR6A2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-376A-3P	99.06	69.17	1128
HSA-MIR-376B-3P	99.06	69.17	1128
HSA-MIR-361-5P	98.95	70.16	1340
HSA-MIR-374A-3P	98.87	67.82	1531
HSA-MIR-640	98.44	66.93	644
HSA-MIR-4529-3P	96.40	66.46	582
HSA-MIR-5704	94.82	67.46	448
HSA-MIR-6503-3P	93.87	66.39	348
HSA-MIR-1295A	85.69	62.42	75

Literature-anchored findings (GeneRIF, showing 3)

• I7 olfactory receptor (PMID:20608641)
• Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. (PMID:35025664)
• Odorant receptors in macrophages: potential targets for atherosclerosis. (PMID:35283015)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or6a2	ENSMUSG00000070417
rattus_norvegicus	Or6a2	ENSRNOG00000085613

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 6A2 — O95222 (reviewed: O95222)

Alternative names: Olfactory receptor 11-55, Olfactory receptor 6A1, Olfactory receptor OR11-83, hP2 olfactory receptor

All UniProt accessions (2): O95222, A0A126GW91

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_003687* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050939	Olfactory_GPCR1	Family

Pfam: PF13853

UniProt features (28 total): topological domain 8, sequence conflict 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95222-F1	83.59	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 102–194

Glycosylation sites (2): 5, 191

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 51 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_DN, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, YOSHIMURA_MAPK8_TARGETS_UP, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, PEDRIOLI_MIR31_TARGETS_DN, PRC2_SUZ12_UP.V1_DN, IL2_UP.V1_UP

GO Biological Process (4): signal transduction (GO:0007165), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911), G protein-coupled receptor signaling pathway (GO:0007186)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor activity	1
signal transduction	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

352 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR6A2	BRI3	O95415	766
OR6A2	TAS2R1	Q9NYW7	471
OR6A2	GSG1	Q2KHT4	369
OR6A2	SCNN1B	P51168	336
OR6A2	MTRNR2L7	P0CJ74	328
OR6A2	TMEM39B	Q9GZU3	310
OR6A2	TAS1R2	Q8TE23	304
OR6A2	CASKIN2	Q8WXE0	269
OR6A2	RIC8B	Q9NVN3	259
OR6A2	SLF2	Q8IX21	246
OR6A2	TAS2R19	P59542	228
OR6A2	SH3BGR	P55822	223
OR6A2	CNGA4	Q8IV77	222
OR6A2	TAS2R38	P59533	219
OR6A2	RHEBL1	Q8TAI7	217
OR6A2	CNGA2	Q16280	217

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR6A2	KIAA1549	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): KIAA1549 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O95006, O95047, O95222, O95371, P23270, P34982, P34984, P58170, Q15622, Q5TZ20, Q60883, Q60889, Q60891, Q6IF42, Q6IFH4, Q7Z3T1, Q8N349, Q8N628, Q8NG92, Q8NG95, Q8NG98, Q8NGA1, Q8NGE9, Q8NGQ2, Q8NGQ5, Q8NGR1, Q8NGR9, Q8NGS0, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGX1, Q8NH03, Q8NH80, Q8NHA4, Q8NHA6

Diamond homologs: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NL26, A6NM76, O14581, O76000, O76100, O95007, O95222, P0C617, P0C626, P0C7N5, P23266, P23267, P23269, P23270, P23272, P30955, P34985, P34986, P47890, P58173, P59922, P70526, Q15622, Q5TZ20, Q60882, Q60886, Q6IEU7, Q6UXT6, Q8N0Y5, Q8N127, Q8N146, Q8N148, Q8N162, Q8N628

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	63
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

172 predictions. Top by Δscore:

Variant	Effect	Δscore
11:6795677:CTCA:C	donor_gain	0.9700
11:6795680:A:AC	donor_gain	0.9700
11:6795681:C:CC	donor_gain	0.9700
11:6795681:CT:C	donor_gain	0.9700
11:6795676:A:AC	donor_gain	0.9600
11:6795677:C:CC	donor_gain	0.9600
11:6795684:T:A	donor_gain	0.9600
11:6795218:TTG:T	donor_gain	0.9500
11:6795680:ACTCT:A	donor_gain	0.9500
11:6795681:CTCTC:C	donor_gain	0.9500
11:6795681:CTCT:C	donor_gain	0.9200
11:6795725:A:AC	donor_gain	0.9100
11:6795726:C:CC	donor_gain	0.9100
11:6795726:CTG:C	donor_gain	0.8600
11:6795677:CT:C	donor_gain	0.8400
11:6795726:CTGCT:C	donor_gain	0.7900
11:6795407:C:A	donor_gain	0.7600
11:6795705:C:CA	donor_gain	0.7600
11:6795721:T:TA	donor_gain	0.7400
11:6795628:TAGTA:T	donor_loss	0.7000
11:6795629:AGTAC:A	donor_loss	0.7000
11:6795630:GTACC:G	donor_loss	0.7000
11:6795631:TA:T	donor_loss	0.7000
11:6795632:ACCTG:A	donor_loss	0.7000
11:6795633:C:A	donor_loss	0.7000
11:6795634:C:A	donor_loss	0.7000
11:6795678:T:C	donor_gain	0.6900
11:6794930:CTGG:C	acceptor_gain	0.6700
11:6795635:T:C	donor_loss	0.6700
11:6794937:C:CA	acceptor_gain	0.6300

AlphaMissense

2133 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:6795670:A:C	F13L	0.978
11:6795670:A:T	F13L	0.978
11:6795672:A:G	F13L	0.978
11:6795143:A:G	L189S	0.965
11:6795671:A:C	F13C	0.959
11:6795163:A:C	F182L	0.958
11:6795163:A:T	F182L	0.958
11:6795165:A:G	F182L	0.958
11:6795158:C:G	C184S	0.955
11:6795159:A:T	C184S	0.955
11:6795160:G:C	F183L	0.952
11:6795160:G:T	F183L	0.952
11:6795162:A:G	F183L	0.952
11:6795665:A:G	L15S	0.947
11:6795158:C:T	C184Y	0.943
11:6795140:A:G	L190P	0.940
11:6795143:A:C	L189W	0.938
11:6795671:A:G	F13S	0.936
11:6794929:A:C	S260R	0.934
11:6794929:A:T	S260R	0.934
11:6794931:T:G	S260R	0.934
11:6795159:A:G	C184R	0.934
11:6795382:G:C	F109L	0.931
11:6795382:G:T	F109L	0.931
11:6795384:A:G	F109L	0.931
11:6794941:G:C	F256L	0.930
11:6794941:G:T	F256L	0.930
11:6794943:A:G	F256L	0.930
11:6795158:C:A	C184F	0.929
11:6795134:A:G	L192P	0.924

dbSNP variants (sampled 300 via entrez): RS1000997044 (11:6800985 C>T), RS1001182659 (11:6799098 A>C), RS1001479897 (11:6797670 C>T), RS1001844619 (11:6799128 G>A,C), RS1002059624 (11:6794996 C>T), RS1002211351 (11:6800681 T>A,C), RS1002697123 (11:6792287 C>T), RS1002733182 (11:6792558 A>G), RS1002846447 (11:6800505 T>C), RS1002987654 (11:6794491 T>C,G), RS1003261240 (11:6792391 AACATTGGAAACC>A), RS1003443788 (11:6800290 G>A,C), RS1004227606 (11:6791905 A>G), RS1005124022 (11:6797804 T>C), RS1005234783 (11:6793087 G>A)

Disease associations

OMIM: gene MIM:608495 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	increases reaction, affects binding	1
Benzo(a)pyrene	increases methylation	1
Lead	increases expression	1
Methotrexate	increases expression	1
Rotenone	increases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.