OR6B3

Summary

OR6B3 (olfactory receptor family 6 subfamily B member 3, HGNC:15042) is a protein-coding gene on chromosome 2q37.3, encoding Olfactory receptor 6B3 (Q8NGW1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 150681 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 50 total
• MANE Select transcript: NM_173351

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15042
Approved symbol	OR6B3
Name	olfactory receptor family 6 subfamily B member 3
Location	2q37.3
Locus type	gene with protein product
Status	Approved
Aliases	OR6B3Q
Ensembl gene	ENSG00000178586
Ensembl biotype	protein_coding
Entrez	150681

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641019, ENST00000943407

RefSeq mRNA: 1 — MANE Select: NM_173351 NM_173351

CCDS: CCDS42837

Canonical transcript exons

ENST00000641019 — 3 exons

Exon	Start	End
ENSE00003811777	240044571	240046097
ENSE00003811983	240046952	240047060
ENSE00003997517	240053460	240053521

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 83.17.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.17	gold quality
tibial nerve	UBERON:0001323	70.41	gold quality
sural nerve	UBERON:0015488	55.93	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	42.14	gold quality
substantia nigra	UBERON:0002038	37.87	gold quality
granulocyte	CL:0000094	37.34	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	37.09	silver quality
right testis	UBERON:0004534	36.79	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
Ammon’s horn	UBERON:0001954	34.97	gold quality
prefrontal cortex	UBERON:0000451	34.39	gold quality
testis	UBERON:0000473	34.39	silver quality
left testis	UBERON:0004533	33.99	silver quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
urinary bladder	UBERON:0001255	32.12	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	30.91	silver quality
frontal cortex	UBERON:0001870	30.73	gold quality
Brodmann (1909) area 9	UBERON:0013540	30.41	silver quality
temporal lobe	UBERON:0001871	30.11	gold quality
leukocyte	CL:0000738	30.08	gold quality
amygdala	UBERON:0001876	30.08	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
cerebral cortex	UBERON:0000956	29.79	gold quality
monocyte	CL:0000576	29.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or6b3	ENSMUSG00000042849
mus_musculus	Or6b2b	ENSMUSG00000057464
mus_musculus	Or6b2	ENSMUSG00000067064
rattus_norvegicus	Or6b3	ENSRNOG00000086068
rattus_norvegicus	Or6b2b	ENSRNOG00000090099

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 6B3 — Q8NGW1 (reviewed: Q8NGW1)

Alternative names: Olfactory receptor OR2-2

All UniProt accessions (1): Q8NGW1

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_775486* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050516	Olfactory_GPCR	Family

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGW1-F1	82.53	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 21 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, METTL14_TARGET_GENES, chr2q37, REACTOME_OLFACTORY_SIGNALING_PATHWAY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (3): cytosol (GO:0005829), plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cellular anatomical structure	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
cytoplasm	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

202 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR6B3	VWC2L	B2RUY7	480
OR6B3	RTP2	Q5QGT7	471
OR6B3	CRACDL	Q6NV74	445
OR6B3	WDR17	Q8IZU2	398
OR6B3	RTP1	P59025	391
OR6B3	ACOXL	Q9NUZ1	338
OR6B3	TRIM58	Q8NG06	328
OR6B3	AK3	Q9UIJ7	290
OR6B3	REEP1	Q9H902	278
OR6B3	TCEAL9	Q9UHQ7	252
OR6B3	YAE1	Q9NRH1	247
OR6B3	VN1R1	Q9GZP7	245
OR6B3	PCYT1A	P49585	232
OR6B3	PIEZO1	Q92508	223
OR6B3	AK4	P27144	222

IntAct

2 interactions, top by confidence:

A	B	Type	Score
SRPK1	OR6B3	psi-mi:“MI:0217”(phosphorylation reaction)	0.440

BioGRID (3): OR6B3 (Reconstituted Complex), OR6B3 (Affinity Capture-MS), OR6B3 (Biochemical Activity)

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A3KFT3, A4D2G3, A6NF89, A6NND4, O43749, O60412, O76099, O76100, O95007, O95222, O95918, P0C7N1, P0C7N5, P0DN81, P23265, P23266, P23267, P23268, P23269, P23270, P23272, P23273, P30953, P34984, P34986, P47881, P47890, P58173, Q0VAX9, Q15619, Q15622, Q5JQS5, Q5TZ20, Q60879, Q60882, Q60886, Q6IFH4, Q7TRF3, Q8NG83, Q8NG98

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

50 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

231 predictions. Top by Δscore:

Variant	Effect	Δscore
2:240045332:C:CT	donor_gain	0.6900
2:240045332:CACGG:C	donor_gain	0.6700
2:240045329:G:T	donor_gain	0.6600
2:240045230:GATAA:G	acceptor_gain	0.6300
2:240045235:C:CC	acceptor_gain	0.6300
2:240045437:C:CT	acceptor_gain	0.6200
2:240045331:C:CT	donor_gain	0.6100
2:240045328:TG:T	donor_gain	0.5900
2:240045367:T:A	donor_gain	0.5900
2:240045232:TAA:T	acceptor_gain	0.5800
2:240045246:A:C	donor_gain	0.5800
2:240045325:CGG:C	donor_gain	0.5800
2:240045624:A:AC	donor_gain	0.5700
2:240045625:C:CC	donor_gain	0.5700
2:240045516:T:TC	acceptor_gain	0.5600
2:240045241:A:AC	donor_gain	0.5500
2:240045242:C:CC	donor_gain	0.5500
2:240045278:AATGG:A	donor_gain	0.5500
2:240045242:CAAAA:C	donor_gain	0.5400
2:240045512:CAGCT:C	acceptor_gain	0.5300
2:240045516:T:C	acceptor_gain	0.5200
2:240045182:AAATT:A	donor_gain	0.5100
2:240045295:CATA:C	donor_loss	0.5100
2:240045296:ATAC:A	donor_loss	0.5100
2:240045297:TA:T	donor_loss	0.5100
2:240045298:A:AC	donor_gain	0.5100
2:240045298:AC:A	donor_loss	0.5100
2:240045299:C:CC	donor_gain	0.5100
2:240045531:ATGTC:A	acceptor_gain	0.5100
2:240045237:G:C	acceptor_gain	0.5000

AlphaMissense

2166 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:240046037:G:C	F12L	0.924
2:240046037:G:T	F12L	0.924
2:240046039:A:G	F12L	0.924
2:240045569:G:C	F168L	0.920
2:240045569:G:T	F168L	0.920
2:240045571:A:G	F168L	0.920
2:240045620:A:C	S151R	0.912
2:240045620:A:T	S151R	0.912
2:240045622:T:G	S151R	0.912
2:240045537:C:G	C179S	0.878
2:240045538:A:T	C179S	0.878
2:240045539:G:C	F178L	0.877
2:240045539:G:T	F178L	0.877
2:240045541:A:G	F178L	0.877
2:240045542:G:C	F177L	0.873
2:240045542:G:T	F177L	0.873
2:240045544:A:G	F177L	0.873
2:240045320:G:C	F251L	0.863
2:240045320:G:T	F251L	0.863
2:240045322:A:G	F251L	0.863
2:240046038:A:C	F12C	0.848
2:240045758:G:C	S105R	0.842
2:240045758:G:T	S105R	0.842
2:240045760:T:G	S105R	0.842
2:240045761:G:C	F104L	0.837
2:240045761:G:T	F104L	0.837
2:240045763:A:G	F104L	0.837
2:240045476:A:C	D199E	0.835
2:240045476:A:T	D199E	0.835
2:240045864:T:A	E70V	0.834

dbSNP variants (sampled 300 via entrez): RS1000151774 (2:240052937 G>A), RS1000285555 (2:240046481 G>A), RS1000732670 (2:240045299 C>A,T), RS1000757271 (2:240051361 G>C), RS1000947530 (2:240044857 G>A), RS1000980086 (2:240044541 G>A), RS1001226832 (2:240049176 A>G), RS1001232169 (2:240051069 G>A), RS1001676983 (2:240050441 G>A), RS1002160128 (2:240050051 C>T), RS1002286375 (2:240044244 C>T), RS1002706179 (2:240048504 G>A), RS1002900758 (2:240047922 T>C), RS1002932638 (2:240054684 G>A), RS1003036397 (2:240053986 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Valproic Acid	increases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.