OR6K3

Summary

OR6K3 (olfactory receptor family 6 subfamily K member 3, HGNC:15030) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 6K3 (Q8NGY3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 391114 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 68 total
• MANE Select transcript: NM_001005327

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15030
Approved symbol	OR6K3
Name	olfactory receptor family 6 subfamily K member 3
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000203757
Ensembl biotype	protein_coding
Entrez	391114

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000368145, ENST00000368146

RefSeq mRNA: 1 — MANE Select: NM_001005327 NM_001005327

CCDS: CCDS30903

Canonical transcript exons

ENST00000368145 — 2 exons

Exon	Start	End
ENSE00001446416	158716327	158718132
ENSE00003813172	158720683	158720720

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 57.89.

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	57.89	gold quality
bone marrow cell	CL:0002092	54.78	silver quality
stromal cell of endometrium	CL:0002255	47.76	gold quality
monocyte	CL:0000576	43.46	silver quality
leukocyte	CL:0000738	43.30	silver quality
blood	UBERON:0000178	42.26	gold quality
right lung	UBERON:0002167	42.24	gold quality
granulocyte	CL:0000094	40.76	gold quality
cortical plate	UBERON:0005343	40.65	silver quality
ventricular zone	UBERON:0003053	40.18	gold quality
sural nerve	UBERON:0015488	40.14	gold quality
lower esophagus mucosa	UBERON:0035834	39.39	gold quality
upper lobe of left lung	UBERON:0008952	39.10	gold quality
lung	UBERON:0002048	37.58	gold quality
ganglionic eminence	UBERON:0004023	37.23	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	36.34	silver quality
lymph node	UBERON:0000029	34.60	gold quality
right coronary artery	UBERON:0001625	33.82	gold quality
calcaneal tendon	UBERON:0003701	33.48	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
duodenum	UBERON:0002114	32.49	gold quality
liver	UBERON:0002107	32.42	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	32.07	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
prefrontal cortex	UBERON:0000451	31.01	gold quality
gall bladder	UBERON:0002110	30.91	gold quality
placenta	UBERON:0001987	29.56	gold quality
corpus callosum	UBERON:0002336	29.29	gold quality
ectocervix	UBERON:0012249	29.02	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.29

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or6k4	ENSMUSG00000051528
rattus_norvegicus	Or6k4	ENSRNOG00000066569

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 6K3 — Q8NGY3 (reviewed: Q8NGY3)

Alternative names: Olfactory receptor OR1-18

All UniProt accessions (2): Q8NGY3, A0A0C4DFU5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005327* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050939	Olfactory_GPCR1	Family

Pfam: PF13853

UniProt features (25 total): topological domain 8, transmembrane region 7, sequence variant 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGY3-F1	87.92	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 113–205

Glycosylation sites (1): 21

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

182 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR6K3	SPATA45	Q537H7	580
OR6K3	LENEP	Q9Y5L5	474
OR6K3	C1orf141	Q5JVX7	446
OR6K3	POTEH	Q6S545	432
OR6K3	SH3BP5L	Q7L8J4	419
OR6K3	RMND5B	Q96G75	418
OR6K3	PLAAT2	Q9NWW9	396
OR6K3	FRRS1	Q6ZNA5	396
OR6K3	MRPS21	P82921	378
OR6K3	DYNLT2B	Q8WW35	373
OR6K3	JAKMIP1	Q96N16	363
OR6K3	AP3S1	Q92572	350
OR6K3	PCDHA8	Q9Y5H6	348
OR6K3	NDST3	O95803	325
OR6K3	C2CD4A	Q8NCU7	325

IntAct

2 interactions, top by confidence:

A	B	Type	Score
EPAS1	POLR2D	psi-mi:“MI:0914”(association)	0.350

BioGRID (4): OR6K3 (Affinity Capture-MS), OR6K3 (Affinity Capture-MS), CUL2 (Affinity Capture-MS), OR6K3 (Affinity Capture-MS)

ESM2 similar proteins: A0A3B3IT45, A6NMU1, A6NND4, O88628, P0C7T3, Q6W049, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGJ4, Q8NGJ8, Q8NGJ9, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK6, Q8NGU1, Q8NGW6, Q8NGY3, Q8NH53, Q8NH54, Q8NH55, Q8NH56, Q8NH57, Q8NH60, Q8NH61, Q8NH63, Q8NH67, Q8NH76, Q8TCB6, Q8VBV9

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

68 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	67
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

468 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158718051:T:A	donor_gain	0.9400
1:158717909:C:CT	acceptor_gain	0.9000
1:158717910:A:T	acceptor_gain	0.9000
1:158717750:T:C	donor_gain	0.8300
1:158717909:C:T	acceptor_gain	0.8000
1:158718047:ACCAT:A	donor_gain	0.7700
1:158718048:CCATC:C	donor_gain	0.7700
1:158717907:TCCA:T	acceptor_gain	0.7400
1:158717908:C:G	acceptor_gain	0.7200
1:158718050:AT:A	donor_gain	0.7000
1:158717813:CAT:C	donor_gain	0.6800
1:158718087:G:C	donor_gain	0.6600
1:158717331:C:CC	acceptor_gain	0.6500
1:158717262:T:TC	acceptor_gain	0.6400
1:158718048:C:A	donor_gain	0.6300
1:158717815:T:TA	donor_gain	0.6200
1:158717356:CA:C	acceptor_gain	0.6000
1:158717814:A:C	donor_gain	0.6000
1:158717247:C:CC	acceptor_gain	0.5900
1:158717329:CG:C	acceptor_gain	0.5900
1:158717968:T:C	acceptor_gain	0.5900
1:158718090:A:AC	donor_gain	0.5900
1:158718091:C:CC	donor_gain	0.5900
1:158718045:C:CT	donor_gain	0.5800
1:158718046:T:TT	donor_gain	0.5800
1:158717328:TCG:T	acceptor_gain	0.5700
1:158717329:CGC:C	acceptor_gain	0.5700
1:158717420:C:CA	donor_gain	0.5700
1:158717243:CAGG:C	acceptor_gain	0.5600
1:158717445:A:AC	donor_gain	0.5600

AlphaMissense

2099 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158717612:G:C	F184L	0.879
1:158717612:G:T	F184L	0.879
1:158717614:A:G	F184L	0.879
1:158717582:G:C	F194L	0.839
1:158717582:G:T	F194L	0.839
1:158717584:A:G	F194L	0.839
1:158718080:A:C	F28L	0.833
1:158718080:A:T	F28L	0.833
1:158718082:A:G	F28L	0.833
1:158718065:G:C	F33L	0.811
1:158718065:G:T	F33L	0.811
1:158718067:A:G	F33L	0.811
1:158717285:A:C	F293L	0.799
1:158717285:A:T	F293L	0.799
1:158717287:A:G	F293L	0.799
1:158717405:A:C	F253L	0.785
1:158717405:A:T	F253L	0.785
1:158717407:A:G	F253L	0.785
1:158717333:G:C	F277L	0.739
1:158717333:G:T	F277L	0.739
1:158717335:A:G	F277L	0.739
1:158717657:G:C	F169L	0.729
1:158717657:G:T	F169L	0.729
1:158717659:A:G	F169L	0.729
1:158717816:C:A	Q116H	0.684
1:158717816:C:G	Q116H	0.684
1:158717363:A:C	F267L	0.679
1:158717363:A:T	F267L	0.679
1:158717365:A:G	F267L	0.679
1:158717366:G:C	F266L	0.679

dbSNP variants (sampled 300 via entrez): RS1000098347 (1:158719470 C>G), RS1000111111 (1:158724180 T>C), RS1000173997 (1:158723623 A>G), RS1000356155 (1:158717626 A>C), RS1000932293 (1:158719107 T>G), RS1001324475 (1:158726364 C>T), RS1001552567 (1:158716846 G>A), RS1001804801 (1:158722123 C>A), RS1001961773 (1:158716555 C>A,T), RS1001965034 (1:158721997 G>A), RS1002095287 (1:158722487 A>C,G,T), RS1002238789 (1:158716837 G>T), RS1002585716 (1:158725487 G>A), RS1002659571 (1:158725848 A>G), RS1002936069 (1:158719148 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	increases reaction, affects binding	1
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.