OR6K6

Summary

OR6K6 (olfactory receptor family 6 subfamily K member 6, HGNC:15033) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 6K6 (Q8NGW6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 128371 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 40 total
• MANE Select transcript: NM_001005184

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15033
Approved symbol	OR6K6
Name	olfactory receptor family 6 subfamily K member 6
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000180433
Ensembl biotype	protein_coding
Entrez	128371

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641861

RefSeq mRNA: 1 — MANE Select: NM_001005184 NM_001005184

CCDS: CCDS30904

Canonical transcript exons

ENST00000641861 — 1 exons

Exon	Start	End
ENSE00001446414	158754720	158755891

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 50.84.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	50.84	gold quality
bone marrow	UBERON:0002371	43.05	gold quality
granulocyte	CL:0000094	39.80	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.49	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
monocyte	CL:0000576	28.95	gold quality
blood	UBERON:0000178	28.46	gold quality
liver	UBERON:0002107	28.31	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.73	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.12	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.14	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
gastrocnemius	UBERON:0001388	23.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or6k6	ENSMUSG00000046486
rattus_norvegicus	Or6k6	ENSRNOG00000085155

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 6K6 — Q8NGW6 (reviewed: Q8NGW6)

Alternative names: Olfactory receptor OR1-21

All UniProt accessions (1): A0A286YF06

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005184* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050939	Olfactory_GPCR1	Family

Pfam: PF13853

UniProt features (28 total): sequence variant 10, topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGW6-F1	83.28	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 125–217

Glycosylation sites (1): 33

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, BOSCO_TH1_CYTOTOXIC_MODULE, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

326 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR6K6	KRTAP12-3	P60328	597
OR6K6	TMEM235	A6NFC5	543
OR6K6	UNC5CL	Q8IV45	515
OR6K6	TMC3	Q7Z5M5	512
OR6K6	C1QTNF8	P60827	447
OR6K6	GOLGA7	Q7Z5G4	418
OR6K6	CCDC57	Q2TAC2	418
OR6K6	TMEM232	C9JQI7	417
OR6K6	LY6G6C	O95867	410
OR6K6	SPATA31D3	P0C874	404
OR6K6	MNDA	P41218	398
OR6K6	FCHSD2	O94868	374
OR6K6	DLEU7	Q6UYE1	369
OR6K6	SPATA31D4	Q6ZUB0	366
OR6K6	LHFPL6	Q9Y693	358

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

40 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	38
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

230 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158754969:G:GA	donor_gain	0.8700
1:158754968:T:TA	donor_gain	0.8600
1:158754886:A:AG	acceptor_gain	0.8300
1:158754887:G:GG	acceptor_gain	0.8300
1:158754928:C:G	donor_gain	0.7900
1:158754964:G:GT	donor_gain	0.7800
1:158754883:CACA:C	acceptor_loss	0.7600
1:158754885:CAG:C	acceptor_loss	0.7600
1:158754886:A:C	acceptor_loss	0.7600
1:158754887:G:A	acceptor_loss	0.7600
1:158754924:GTGAC:G	donor_gain	0.7600
1:158754925:TGACT:T	donor_gain	0.7600
1:158754926:GACTG:G	donor_gain	0.7600
1:158754927:ACTGA:A	donor_gain	0.7600
1:158754877:T:TA	acceptor_loss	0.7300
1:158754970:G:GG	donor_gain	0.7100
1:158754971:C:G	donor_gain	0.7100
1:158754877:T:A	acceptor_gain	0.6800
1:158754887:GAT:G	acceptor_gain	0.6500
1:158754737:G:GT	donor_gain	0.6300
1:158754886:AGAT:A	acceptor_gain	0.6000
1:158754887:GATG:G	acceptor_gain	0.6000
1:158754800:C:G	donor_gain	0.5900
1:158754796:G:GG	donor_gain	0.5800
1:158754795:A:AG	donor_gain	0.5700
1:158754838:A:AG	donor_gain	0.5500
1:158754792:T:G	donor_gain	0.5400
1:158754831:G:GG	donor_gain	0.5200
1:158754956:T:G	acceptor_gain	0.5200
1:158755105:T:TA	acceptor_gain	0.5200

AlphaMissense

2110 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158755431:T:C	F206L	0.921
1:158755433:C:A	F206L	0.921
1:158755433:C:G	F206L	0.921
1:158755401:T:C	F196L	0.918
1:158755403:C:A	F196L	0.918
1:158755403:C:G	F196L	0.918
1:158754933:T:C	F40L	0.910
1:158754935:C:A	F40L	0.910
1:158754935:C:G	F40L	0.910
1:158755728:T:C	F305L	0.894
1:158755730:T:A	F305L	0.894
1:158755730:T:G	F305L	0.894
1:158755656:A:C	S281R	0.888
1:158755658:T:A	S281R	0.888
1:158755658:T:G	S281R	0.888
1:158755199:G:C	Q128H	0.866
1:158755199:G:T	Q128H	0.866
1:158754934:T:C	F40S	0.852
1:158755647:T:C	F278L	0.836
1:158755649:T:A	F278L	0.836
1:158755649:T:G	F278L	0.836
1:158755402:T:G	F196C	0.825
1:158755650:T:C	F279L	0.819
1:158755652:T:A	F279L	0.819
1:158755652:T:G	F279L	0.819
1:158755767:A:C	S318R	0.815
1:158755769:C:A	S318R	0.815
1:158755769:C:G	S318R	0.815
1:158754934:T:G	F40C	0.814
1:158755608:T:C	F265L	0.807

dbSNP variants (sampled 300 via entrez): RS1001564939 (1:158753344 G>A), RS1001597548 (1:158753674 A>G), RS1003569883 (1:158755914 C>A,T), RS1003697930 (1:158753362 G>A), RS1004399036 (1:158756107 A>C), RS1004705412 (1:158752931 A>T), RS1005187800 (1:158753193 A>G,T), RS1006104537 (1:158755401 T>C), RS1006405605 (1:158754496 C>G), RS1006769784 (1:158752886 A>G), RS1009950137 (1:158755446 C>T), RS1010023801 (1:158755606 C>T), RS1010490294 (1:158753700 G>A), RS1010575846 (1:158753607 A>G), RS1010670548 (1:158753337 C>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	increases reaction, affects binding	1
Benzo(a)pyrene	affects methylation, increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.