OR6M1

Summary

OR6M1 (olfactory receptor family 6 subfamily M member 1, HGNC:14711) is a protein-coding gene on chromosome 11q24.1, encoding Olfactory receptor 6M1 (Q8NGM8). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390261 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 49 total
• MANE Select transcript: NM_001005325

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14711
Approved symbol	OR6M1
Name	olfactory receptor family 6 subfamily M member 1
Location	11q24.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000196099
Ensembl biotype	protein_coding
Entrez	390261

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000309154

RefSeq mRNA: 1 — MANE Select: NM_001005325 NM_001005325

CCDS: CCDS31696

Canonical transcript exons

ENST00000309154 — 1 exons

Exon	Start	End
ENSE00001204792	123805408	123806349

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 51.65.

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	51.65	gold quality
body of pancreas	UBERON:0001150	51.25	gold quality
right lobe of liver	UBERON:0001114	47.30	gold quality
pancreas	UBERON:0001264	43.52	gold quality
rectum	UBERON:0001052	41.67	silver quality
liver	UBERON:0002107	40.47	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	34.96	gold quality
muscle tissue	UBERON:0002385	32.22	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
transverse colon	UBERON:0001157	31.31	gold quality
superior frontal gyrus	UBERON:0002661	31.18	silver quality
sural nerve	UBERON:0015488	30.93	gold quality
tonsil	UBERON:0002372	30.45	gold quality
placenta	UBERON:0001987	30.35	silver quality
calcaneal tendon	UBERON:0003701	30.19	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.27	gold quality
leukocyte	CL:0000738	29.12	gold quality
duodenum	UBERON:0002114	28.14	gold quality
corpus callosum	UBERON:0002336	28.01	gold quality
adrenal tissue	UBERON:0018303	27.80	gold quality
primary visual cortex	UBERON:0002436	27.72	gold quality
colon	UBERON:0001155	27.65	silver quality
right coronary artery	UBERON:0001625	27.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.96

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (18): OR6F1 (ENSG00000169214), OR2AP1 (ENSG00000179615), OR6C4 (ENSG00000179626), OR6C2 (ENSG00000179695), OR6T1 (ENSG00000181499), OR6S1 (ENSG00000181803), OR6C70 (ENSG00000184954), OR6C76 (ENSG00000185821), OR6C75 (ENSG00000187857), OR6C6 (ENSG00000188324), OR6C74 (ENSG00000197706), OR6C68 (ENSG00000205327), OR6C65 (ENSG00000205328), OR6C3 (ENSG00000205329), OR6C1 (ENSG00000205330), OR6X1 (ENSG00000221931), OR6V1 (ENSG00000225781), OR6J1 (ENSG00000255804)

Protein

Protein identifiers

Olfactory receptor 6M1 — Q8NGM8 (reviewed: Q8NGM8)

Alternative names: Olfactory receptor OR11-271

All UniProt accessions (2): A0A126GVK2, Q8NGM8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005325* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR047132	Olfact_rcpt_6C-like	Family

Pfam: PF00001

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGM8-F1	91.03	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–186

Glycosylation sites (2): 3, 262

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

138 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR6M1	FAM217A	Q8IXS0	581
OR6M1	RSPH10B2	B2RC85	507
OR6M1	MROH9	Q5TGP6	507
OR6M1	RSPH10B	P0C881	474
OR6M1	CCDC81	Q6ZN84	447
OR6M1	MFSD6L	Q8IWD5	447
OR6M1	TMPRSS12	Q86WS5	436
OR6M1	RTP2	Q5QGT7	419
OR6M1	KRTCAP3	Q53RY4	417
OR6M1	ESPNL	Q6ZVH7	400
OR6M1	PCDHGA6	Q9Y5G7	396
OR6M1	GPR62	Q9BZJ7	395
OR6M1	SIAH3	Q8IW03	370
OR6M1	ZMAT4	Q9H898	358
OR6M1	LCE3A	Q5TA76	358

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR6M1	RPSA2	psi-mi:“MI:0914”(association)	0.350

BioGRID (7): OR6M1 (Negative Genetic), HERC3 (Affinity Capture-MS), RPSAP58 (Affinity Capture-MS), FAM63A (Affinity Capture-MS), NPLOC4 (Affinity Capture-MS), RHBDD1 (Affinity Capture-MS), ZFAND2B (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60878, Q60881, Q6IEV9, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGD0, Q8NGD1, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGL6, Q8NGL7, Q8NGL9, Q8NGM1, Q8NGM8, Q8NGN0, Q8NGN8, Q8NGP0, Q8NH05, Q8NH37, Q8NH42

Diamond homologs: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NL26, A6NM76, O76001, O76002, O76100, O95007, P0C623, P0C626, P23266, P23267, P23272, P23274, P30953, P30955, P34985, P58173, P59922, P70526, Q13606, Q5TZ20, Q60882, Q60890, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N146, Q8N148, Q8N162, Q8N628, Q8NGA1, Q8NGC5, Q8NGE1, Q8NGE2, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

305 predictions. Top by Δscore:

Variant	Effect	Δscore
11:123806164:A:AC	donor_gain	0.9400
11:123806165:C:CC	donor_gain	0.9400
11:123805950:TGATG:T	donor_gain	0.9100
11:123805938:C:CA	donor_gain	0.9000
11:123805916:C:A	donor_gain	0.8800
11:123805954:G:T	donor_gain	0.8700
11:123805952:A:AC	donor_gain	0.8400
11:123805915:T:TA	donor_gain	0.8300
11:123805935:AGGC:A	donor_gain	0.8100
11:123805463:T:TA	donor_gain	0.7700
11:123806180:A:C	donor_gain	0.7700
11:123805904:C:CA	donor_gain	0.7500
11:123806003:A:AC	donor_gain	0.7500
11:123806161:A:AC	donor_gain	0.7500
11:123806178:A:AC	donor_gain	0.6700
11:123806179:C:CC	donor_gain	0.6700
11:123805602:C:CT	acceptor_gain	0.6500
11:123806158:CAAA:C	donor_gain	0.6500
11:123805921:A:T	donor_gain	0.6400
11:123805602:C:T	acceptor_gain	0.6300
11:123805912:G:C	donor_gain	0.6100
11:123805845:T:A	donor_gain	0.6000
11:123805798:CAC:C	acceptor_gain	0.5800
11:123805911:AGCAT:A	donor_gain	0.5800
11:123806002:CA:C	donor_gain	0.5800
11:123806175:A:AC	donor_gain	0.5800
11:123805903:T:TA	donor_gain	0.5700
11:123805919:A:AC	donor_gain	0.5700
11:123805601:CCG:C	acceptor_gain	0.5600
11:123805904:CCC:C	donor_gain	0.5600

AlphaMissense

2042 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:123805825:G:C	F175L	0.907
11:123805825:G:T	F175L	0.907
11:123805827:A:G	F175L	0.907
11:123805732:G:C	S206R	0.899
11:123805732:G:T	S206R	0.899
11:123805734:T:G	S206R	0.899
11:123805486:G:C	S288R	0.880
11:123805486:G:T	S288R	0.880
11:123805488:T:G	S288R	0.880
11:123806020:A:C	F110L	0.873
11:123806020:A:T	F110L	0.873
11:123806022:A:G	F110L	0.873
11:123805828:G:C	F174L	0.867
11:123805828:G:T	F174L	0.867
11:123805830:A:G	F174L	0.867
11:123805991:C:G	R120P	0.865
11:123805645:A:C	F235L	0.859
11:123805645:A:T	F235L	0.859
11:123805647:A:G	F235L	0.859
11:123806002:C:A	M116I	0.852
11:123806002:C:G	M116I	0.852
11:123806002:C:T	M116I	0.852
11:123805597:G:C	S251R	0.851
11:123805597:G:T	S251R	0.851
11:123805599:T:G	S251R	0.851
11:123806230:G:C	N40K	0.839
11:123806230:G:T	N40K	0.839
11:123806041:G:C	F103L	0.831
11:123806041:G:T	F103L	0.831
11:123806043:A:G	F103L	0.831

dbSNP variants (sampled 300 via entrez): RS1001013634 (11:123805067 C>A,T), RS1001159134 (11:123806557 T>TG), RS1004938209 (11:123807175 C>T), RS1005308927 (11:123807353 T>C), RS1006416106 (11:123807214 C>T), RS1006751413 (11:123805827 A>C,G), RS1010134478 (11:123806544 G>C), RS1010994791 (11:123805090 C>T), RS1011168092 (11:123807956 C>T), RS1012847552 (11:123806615 C>T), RS1012900280 (11:123806870 A>G), RS1013236433 (11:123805511 G>A), RS1013553232 (11:123806592 G>A), RS1013893496 (11:123805240 G>T), RS1016318534 (11:123807355 T>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004751_16	Serum uric acid levels in response to allopurinol in gout	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004761	uric acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol F	affects cotreatment, decreases methylation	1
CGP 52608	increases reaction, affects binding	1
Fulvestrant	affects cotreatment, decreases methylation	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Endosulfan	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.