OR6N1

Summary

OR6N1 (olfactory receptor family 6 subfamily N member 1, HGNC:15034) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 6N1 (Q8NGY5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 128372 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 88 total
• MANE Select transcript: NM_001005185

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15034
Approved symbol	OR6N1
Name	olfactory receptor family 6 subfamily N member 1
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000197403
Ensembl biotype	protein_coding
Entrez	128372

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding_CDS_not_defined, 1 protein_coding

ENST00000641189, ENST00000641846

RefSeq mRNA: 1 — MANE Select: NM_001005185 NM_001005185

CCDS: CCDS30905

Canonical transcript exons

ENST00000641846 — 2 exons

Exon	Start	End
ENSE00003812225	158764236	158766700
ENSE00003813559	158772021	158772195

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 70.55.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	70.55	gold quality
granulocyte	CL:0000094	58.04	gold quality
bone marrow cell	CL:0002092	57.66	gold quality
blood	UBERON:0000178	55.50	gold quality
monocyte	CL:0000576	51.15	gold quality
leukocyte	CL:0000738	50.33	gold quality
upper lobe of left lung	UBERON:0008952	45.21	gold quality
lung	UBERON:0002048	42.41	gold quality
right testis	UBERON:0004534	39.92	gold quality
metanephros cortex	UBERON:0010533	39.31	gold quality
lower esophagus mucosa	UBERON:0035834	39.09	gold quality
sural nerve	UBERON:0015488	38.47	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
testis	UBERON:0000473	36.31	gold quality
left testis	UBERON:0004533	35.67	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
spleen	UBERON:0002106	34.32	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
right lung	UBERON:0002167	32.59	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
right uterine tube	UBERON:0001302	31.05	gold quality
cortex of kidney	UBERON:0001225	30.89	gold quality
lymph node	UBERON:0000029	29.98	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.51	gold quality
vermiform appendix	UBERON:0001154	29.25	gold quality
islet of Langerhans	UBERON:0000006	28.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.11

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or6n1	ENSMUSG00000049528
rattus_norvegicus	Or6n1	ENSRNOG00000022387

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 6N1 — Q8NGY5 (reviewed: Q8NGY5)

All UniProt accessions (1): Q8NGY5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005185* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050939	Olfactory_GPCR1	Family

Pfam: PF13853

UniProt features (24 total): topological domain 8, transmembrane region 7, sequence variant 5, chain 1, glycosylation site 1, disulfide bond 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGY5-F1	91.26	0.76

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, SRPK1_TARGET_GENES, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

156 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR6N1	LITAFD	A0A1B0GVX0	659
OR6N1	RCBTB1	Q8NDN9	570
OR6N1	H3BQ15	H3BQ15	494
OR6N1	AMDHD2	Q9Y303	493
OR6N1	TAS2R60	P59551	448
OR6N1	TMEM248	Q9NWD8	447
OR6N1	ADGRF3	Q8IZF5	419
OR6N1	CARHSP1	Q9Y2V2	410
OR6N1	SETDB2	Q96T68	408
OR6N1	ATP1B4	Q9UN42	391
OR6N1	STX10	O60499	358
OR6N1	NXNL1	Q96CM4	348
OR6N1	CSHL1	Q14406	348
OR6N1	HNF4G	Q14541	336
OR6N1	TAAR5	O14804	323

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR6N1	B3GALT5	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): B3GALT5 (Affinity Capture-MS)

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

88 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	84
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

381 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158766422:A:AC	donor_gain	0.9300
1:158766423:C:CC	donor_gain	0.9300
1:158766321:T:C	donor_gain	0.9200
1:158754969:G:GA	donor_gain	0.8700
1:158754968:T:TA	donor_gain	0.8600
1:158766538:C:CT	donor_gain	0.8400
1:158754886:A:AG	acceptor_gain	0.8300
1:158754887:G:GG	acceptor_gain	0.8300
1:158754928:C:G	donor_gain	0.7900
1:158754964:G:GT	donor_gain	0.7800
1:158766418:T:TA	donor_gain	0.7700
1:158754883:CACA:C	acceptor_loss	0.7600
1:158754885:CAG:C	acceptor_loss	0.7600
1:158754886:A:C	acceptor_loss	0.7600
1:158754887:G:A	acceptor_loss	0.7600
1:158754924:GTGAC:G	donor_gain	0.7600
1:158754925:TGACT:T	donor_gain	0.7600
1:158754926:GACTG:G	donor_gain	0.7600
1:158754927:ACTGA:A	donor_gain	0.7600
1:158766333:G:C	donor_gain	0.7500
1:158754877:T:TA	acceptor_loss	0.7300
1:158766618:C:CA	donor_gain	0.7200
1:158754970:G:GG	donor_gain	0.7100
1:158754971:C:G	donor_gain	0.7100
1:158765926:C:CT	acceptor_gain	0.7000
1:158766023:C:CC	acceptor_gain	0.6900
1:158754877:T:A	acceptor_gain	0.6800
1:158766029:A:C	acceptor_gain	0.6800
1:158766311:TAAA:T	donor_gain	0.6800
1:158766539:C:CT	donor_gain	0.6700

AlphaMissense

2022 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158766149:A:C	F178L	0.956
1:158766149:A:T	F178L	0.956
1:158766151:A:G	F178L	0.956
1:158766179:G:C	F168L	0.951
1:158766179:G:T	F168L	0.951
1:158766181:A:G	F168L	0.951
1:158766647:G:C	F12L	0.946
1:158766647:G:T	F12L	0.946
1:158766649:A:G	F12L	0.946
1:158765810:G:C	S291R	0.934
1:158765810:G:T	S291R	0.934
1:158765812:T:G	S291R	0.934
1:158766329:C:A	M118I	0.928
1:158766329:C:G	M118I	0.928
1:158766329:C:T	M118I	0.928
1:158766632:G:C	F17L	0.924
1:158766632:G:T	F17L	0.924
1:158766634:A:G	F17L	0.924
1:158765921:G:C	S254R	0.917
1:158765921:G:T	S254R	0.917
1:158765923:T:G	S254R	0.917
1:158765930:G:C	F251L	0.912
1:158765930:G:T	F251L	0.912
1:158765932:A:G	F251L	0.912
1:158766648:A:G	F12S	0.893
1:158766549:A:T	I45K	0.889
1:158766320:A:C	D121E	0.884
1:158766320:A:T	D121E	0.884
1:158766162:A:G	I174T	0.882
1:158766321:T:G	D121A	0.882

dbSNP variants (sampled 300 via entrez): RS1000012808 (1:158810973 T>C,G), RS1000020171 (1:158831854 G>A), RS1000026725 (1:158784357 G>T), RS1000110928 (1:158799147 A>G), RS1000140086 (1:158838491 T>C), RS1000225710 (1:158819721 C>T), RS1000261373 (1:158838779 A>G), RS1000271966 (1:158768705 C>A,T), RS1000328381 (1:158791450 G>C), RS1000358436 (1:158785300 T>C), RS1000389557 (1:158785678 C>G), RS1000465757 (1:158826108 A>C), RS1000556881 (1:158779568 A>G), RS1000563307 (1:158820785 G>C), RS1000573108 (1:158827228 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Resveratrol	decreases expression, affects cotreatment	1
Benzo(a)pyrene	decreases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.