OR6N2

Summary

OR6N2 (olfactory receptor family 6 subfamily N member 2, HGNC:15035) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 6N2 (Q8NGY6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81442 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001005278

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15035
Approved symbol	OR6N2
Name	olfactory receptor family 6 subfamily N member 2
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000188340
Ensembl biotype	protein_coding
Entrez	81442

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641131

RefSeq mRNA: 1 — MANE Select: NM_001005278 NM_001005278

CCDS: CCDS30906

Canonical transcript exons

ENST00000641131 — 2 exons

Exon	Start	End
ENSE00003812025	158774222	158777641
ENSE00003814095	158781170	158781204

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 58.03.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	58.03	gold quality
bone marrow cell	CL:0002092	57.97	silver quality
colonic epithelium	UBERON:0000397	45.18	gold quality
monocyte	CL:0000576	39.50	gold quality
leukocyte	CL:0000738	39.02	gold quality
granulocyte	CL:0000094	37.85	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
blood	UBERON:0000178	32.45	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
tonsil	UBERON:0002372	30.32	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	29.03	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
urinary bladder	UBERON:0001255	27.52	gold quality
islet of Langerhans	UBERON:0000006	26.88	gold quality
lung	UBERON:0002048	26.57	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
upper lobe of left lung	UBERON:0008952	25.69	gold quality
muscle of leg	UBERON:0001383	24.85	gold quality
pancreas	UBERON:0001264	24.73	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.95

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or6n2	ENSMUSG00000050134
rattus_norvegicus	Or6n2	ENSRNOG00000077027

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 6N2 — Q8NGY6 (reviewed: Q8NGY6)

Alternative names: Olfactory receptor OR1-23

All UniProt accessions (2): A0A126GV57, Q8NGY6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005278* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050939	Olfactory_GPCR1	Family

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGY6-F1	89.34	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

156 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR6N2	LITAFD	A0A1B0GVX0	641
OR6N2	KRTAP19-1	Q8IUB9	530
OR6N2	H3BQ15	H3BQ15	490
OR6N2	AMDHD2	Q9Y303	489
OR6N2	KRTAP24-1	Q3LI83	480
OR6N2	RCBTB1	Q8NDN9	463
OR6N2	PLEKHA4	Q9H4M7	390
OR6N2	CARHSP1	Q9Y2V2	389
OR6N2	MNDA	P41218	385
OR6N2	ABHD17B	Q5VST6	376
OR6N2	LRFN3	Q9BTN0	375
OR6N2	SETDB2	Q96T68	340
OR6N2	OLFM3	Q96PB7	323
OR6N2	PRLHR	P49683	320
OR6N2	TLDC2	A0PJX2	311
OR6N2	C11orf68	Q9H3H3	311

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A0A3B3IT45, A4D2G3, A6NGY5, A6NMU1, A6NND4, O43749, O88628, P0C646, P0C7T3, P23266, P23269, P23273, P23274, P30954, P34982, P34984, P70526, Q15619, Q60884, Q60892, Q6IF63, Q6IFG1, Q6W049, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

199 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158777463:G:C	donor_gain	0.9800
1:158777462:A:AC	donor_gain	0.9700
1:158777460:A:C	donor_gain	0.8700
1:158777447:G:T	donor_gain	0.8500
1:158777448:A:AC	donor_gain	0.8100
1:158777449:C:CC	donor_gain	0.8100
1:158777420:C:CT	donor_gain	0.7900
1:158777510:G:GC	donor_gain	0.7700
1:158777514:C:CT	donor_gain	0.7500
1:158777450:A:C	donor_gain	0.7300
1:158776991:CA:C	acceptor_gain	0.7200
1:158777414:TGTA:T	donor_gain	0.7100
1:158777064:T:TA	donor_gain	0.7000
1:158777507:CATG:C	donor_gain	0.7000
1:158777475:G:C	donor_gain	0.6700
1:158777455:G:GC	donor_gain	0.6500
1:158777154:A:AC	donor_gain	0.6300
1:158777481:T:TA	donor_gain	0.6300
1:158776992:A:C	acceptor_gain	0.6200
1:158777156:G:T	donor_gain	0.6200
1:158777458:A:AC	donor_gain	0.6200
1:158777459:C:CC	donor_gain	0.6200
1:158777041:C:CT	donor_gain	0.6100
1:158776977:C:CC	acceptor_gain	0.6000
1:158776977:C:T	acceptor_gain	0.6000
1:158776974:ATCCT:A	acceptor_loss	0.5900
1:158776975:TCC:T	acceptor_loss	0.5900
1:158776976:CC:C	acceptor_loss	0.5900
1:158776977:C:CG	acceptor_loss	0.5900
1:158776992:A:T	acceptor_gain	0.5900

AlphaMissense

2085 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158776763:A:C	S291R	0.987
1:158776763:A:T	S291R	0.987
1:158776765:T:G	S291R	0.987
1:158776874:G:C	S254R	0.977
1:158776874:G:T	S254R	0.977
1:158776876:T:G	S254R	0.977
1:158776778:A:C	N286K	0.974
1:158776778:A:T	N286K	0.974
1:158777102:G:C	F178L	0.974
1:158777102:G:T	F178L	0.974
1:158777104:A:G	F178L	0.974
1:158777282:C:A	M118I	0.973
1:158777282:C:G	M118I	0.973
1:158777282:C:T	M118I	0.973
1:158777274:T:G	D121A	0.968
1:158777600:A:C	F12L	0.966
1:158777600:A:T	F12L	0.966
1:158777602:A:G	F12L	0.966
1:158777274:T:A	D121V	0.963
1:158777259:A:T	I126N	0.960
1:158776776:G:T	P287Q	0.959
1:158776880:A:C	F252L	0.959
1:158776880:A:T	F252L	0.959
1:158776882:A:G	F252L	0.959
1:158777270:T:A	R122S	0.957
1:158777270:T:G	R122S	0.957
1:158777100:C:G	C179S	0.955
1:158777101:A:T	C179S	0.955
1:158777191:A:G	W149R	0.955
1:158777191:A:T	W149R	0.955

dbSNP variants (sampled 300 via entrez): RS1000556881 (1:158779568 A>G), RS1001040670 (1:158775171 G>A), RS1001182268 (1:158776894 C>A,T), RS1001447492 (1:158776208 T>C), RS1001639693 (1:158777213 A>C), RS1002275329 (1:158782605 G>C,T), RS1002580546 (1:158782270 T>C), RS1002592067 (1:158778148 T>C), RS1003262257 (1:158775654 T>C), RS1003303700 (1:158781280 C>T), RS1003369152 (1:158781666 G>A), RS1003971458 (1:158778476 C>T), RS1004023746 (1:158778741 A>G), RS1004312676 (1:158778374 G>T), RS1004967599 (1:158774559 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.