OR6P1

Summary

OR6P1 (olfactory receptor family 6 subfamily P member 1, HGNC:15036) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 6P1 (Q8NGX9). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 128366 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_001160325

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15036
Approved symbol	OR6P1
Name	olfactory receptor family 6 subfamily P member 1
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000186440
Ensembl biotype	protein_coding
Entrez	128366

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641540

RefSeq mRNA: 1 — MANE Select: NM_001160325 NM_001160325

CCDS: CCDS53391

Canonical transcript exons

ENST00000641540 — 3 exons

Exon	Start	End
ENSE00003811631	158560606	158563626
ENSE00003812184	158566764	158566858
ENSE00003812517	158570442	158570580

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 41.24.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	41.24	gold quality
bone marrow cell	CL:0002092	38.18	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.18	gold quality
sural nerve	UBERON:0015488	34.99	gold quality
granulocyte	CL:0000094	34.27	gold quality
bone marrow	UBERON:0002371	32.78	gold quality
muscle tissue	UBERON:0002385	32.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
leukocyte	CL:0000738	31.69	gold quality
monocyte	CL:0000576	31.58	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.34	gold quality
liver	UBERON:0002107	28.31	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.27	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	24.91	gold quality
calcaneal tendon	UBERON:0003701	24.76	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 6P1 — Q8NGX9 (reviewed: Q8NGX9)

Alternative names: Olfactory receptor OR1-12

All UniProt accessions (2): A0A126GV72, Q8NGX9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001153797* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050939	Olfactory_GPCR1	Family

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGX9-F1	85.34	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 3, 186

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, chr1q23

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

290 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR6P1	PCDHGA8	Q9Y5G5	480
OR6P1	PCDHGA5	Q9Y5G8	479
OR6P1	PCDHGA10	Q9Y5H3	476
OR6P1	PCDHGA7	Q9Y5G6	475
OR6P1	PCDHGA4	Q9Y5G9	469
OR6P1	ZNF677	Q86XU0	447
OR6P1	PCDHGA6	Q9Y5G7	445
OR6P1	PCDHGA2	Q9Y5H1	441
OR6P1	PCDHGA9	Q9Y5G4	439
OR6P1	PCDHGA3	Q9Y5H0	432
OR6P1	NUDT16L1	Q9BRJ7	419
OR6P1	TAS2R16	Q9NYV7	418
OR6P1	PCDHGA11	Q9Y5H2	417
OR6P1	PCDHGA1	Q9Y5H4	405
OR6P1	PCDHGA12	O60330	379

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NL26, A6NM76, O76001, O76002, O76100, O95007, P0C623, P0C626, P23266, P23267, P23272, P23274, P30953, P30955, P34985, P58173, P59922, P70526, Q13606, Q5TZ20, Q60882, Q60890, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N146, Q8N148, Q8N162, Q8N628, Q8NGA1, Q8NGC5, Q8NGE1, Q8NGE2, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	60
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

283 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158562828:A:C	acceptor_gain	0.7000
1:158562963:C:CT	acceptor_gain	0.6800
1:158562969:CAA:C	acceptor_gain	0.6800
1:158562932:TGG:T	acceptor_gain	0.6600
1:158562935:C:CC	acceptor_gain	0.6600
1:158562949:G:GC	acceptor_gain	0.6600
1:158562947:CAG:C	acceptor_gain	0.6400
1:158563316:A:AT	donor_gain	0.6100
1:158562823:CG:C	acceptor_gain	0.6000
1:158562956:A:C	acceptor_gain	0.6000
1:158562860:C:CT	donor_gain	0.5900
1:158563039:CAGG:C	acceptor_gain	0.5900
1:158563055:G:C	acceptor_gain	0.5900
1:158563339:T:TA	donor_gain	0.5900
1:158562824:G:C	acceptor_gain	0.5800
1:158563048:T:TC	acceptor_gain	0.5800
1:158563055:G:GC	acceptor_gain	0.5800
1:158563040:A:T	acceptor_gain	0.5700
1:158563052:G:C	acceptor_gain	0.5700
1:158563052:G:GC	acceptor_gain	0.5700
1:158562966:A:T	acceptor_gain	0.5600
1:158563042:G:C	acceptor_gain	0.5600
1:158563332:TC:T	donor_gain	0.5600
1:158562743:C:CC	acceptor_gain	0.5500
1:158562861:A:AT	donor_gain	0.5500
1:158562863:C:CT	donor_gain	0.5500
1:158562956:A:AC	acceptor_gain	0.5500
1:158563321:A:AC	donor_gain	0.5500
1:158563322:C:CC	donor_gain	0.5500
1:158562970:A:T	acceptor_gain	0.5400

AlphaMissense

2066 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158563569:A:C	F12L	0.960
1:158563569:A:T	F12L	0.960
1:158563571:A:G	F12L	0.960
1:158563140:G:C	S155R	0.958
1:158563140:G:T	S155R	0.958
1:158563142:T:G	S155R	0.958
1:158563074:A:C	F177L	0.951
1:158563074:A:T	F177L	0.951
1:158563076:A:G	F177L	0.951
1:158563069:C:G	C179S	0.940
1:158563070:A:T	C179S	0.940
1:158563570:A:C	F12C	0.936
1:158563071:G:C	F178L	0.935
1:158563071:G:T	F178L	0.935
1:158563073:A:G	F178L	0.935
1:158563005:G:C	F200L	0.927
1:158563005:G:T	F200L	0.927
1:158563007:A:G	F200L	0.927
1:158563069:C:T	C179Y	0.920
1:158563008:G:C	D199E	0.917
1:158563008:G:T	D199E	0.917
1:158563396:T:A	E70V	0.917
1:158563152:A:C	S151R	0.915
1:158563152:A:T	S151R	0.915
1:158563154:T:G	S151R	0.915
1:158563391:A:G	W72R	0.914
1:158563391:A:T	W72R	0.914
1:158563070:A:G	C179R	0.913
1:158563554:G:C	F17L	0.913
1:158563554:G:T	F17L	0.913

dbSNP variants (sampled 300 via entrez): RS1000047765 (1:158564151 G>A,C), RS1000336570 (1:158564345 A>G), RS1000358697 (1:158563739 A>G), RS1000373794 (1:158570855 G>A), RS1000828120 (1:158570592 C>T), RS1000973654 (1:158565680 C>A), RS1001212940 (1:158570686 C>T), RS1001542148 (1:158560307 T>C,G), RS1001550301 (1:158563302 C>G,T), RS1001566007 (1:158560435 T>G), RS1001645143 (1:158563081 T>C), RS1001662392 (1:158570848 G>A), RS1001880627 (1:158561754 C>T), RS1001994422 (1:158572311 A>G), RS1001996686 (1:158561365 AT>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST003542_29	Night sleep phenotypes	6.000000e-06
GCST003649_6	Pneumococcal bacteremia	1.000000e-06
GCST007997_12	Obesity (extreme) (SNP x SNP interaction)	3.000000e-09
GCST007997_21	Obesity (extreme) (SNP x SNP interaction)	7.000000e-09
GCST007997_30	Obesity (extreme) (SNP x SNP interaction)	5.000000e-09
GCST007997_39	Obesity (extreme) (SNP x SNP interaction)	7.000000e-10
GCST90002384_12	Hemoglobin	3.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:1001925	pneumococcal bacteremia
EFO:0004509	hemoglobin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
butyraldehyde	increases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	decreases methylation, increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.