OR6T1

Summary

OR6T1 (olfactory receptor family 6 subfamily T member 1, HGNC:14848) is a protein-coding gene on chromosome 11q24.1, encoding Olfactory receptor 6T1 (Q8NGN1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219874 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 44 total
• MANE Select transcript: NM_001005187

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14848
Approved symbol	OR6T1
Name	olfactory receptor family 6 subfamily T member 1
Location	11q24.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181499
Ensembl biotype	protein_coding
Entrez	219874

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000321252

RefSeq mRNA: 1 — MANE Select: NM_001005187 NM_001005187

CCDS: CCDS31700

Canonical transcript exons

ENST00000321252 — 1 exons

Exon	Start	End
ENSE00001262215	123942867	123943838

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 46.82.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	46.82	gold quality
colonic epithelium	UBERON:0000397	46.21	gold quality
pancreas	UBERON:0001264	41.45	gold quality
rectum	UBERON:0001052	41.27	gold quality
mucosa of transverse colon	UBERON:0004991	38.33	silver quality
bone marrow cell	CL:0002092	37.97	gold quality
granulocyte	CL:0000094	37.05	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.67	gold quality
muscle tissue	UBERON:0002385	32.27	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
placenta	UBERON:0001987	30.02	gold quality
islet of Langerhans	UBERON:0000006	29.99	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
calcaneal tendon	UBERON:0003701	29.79	gold quality
prefrontal cortex	UBERON:0000451	29.39	gold quality
leukocyte	CL:0000738	29.33	gold quality
corpus callosum	UBERON:0002336	29.21	gold quality
monocyte	CL:0000576	28.87	gold quality
transverse colon	UBERON:0001157	28.77	silver quality
liver	UBERON:0002107	28.64	gold quality
adrenal tissue	UBERON:0018303	28.63	gold quality
duodenum	UBERON:0002114	28.14	gold quality
smooth muscle tissue	UBERON:0001135	27.93	gold quality
lymph node	UBERON:0000029	27.57	gold quality
superior frontal gyrus	UBERON:0002661	27.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (18): OR6F1 (ENSG00000169214), OR2AP1 (ENSG00000179615), OR6C4 (ENSG00000179626), OR6C2 (ENSG00000179695), OR6S1 (ENSG00000181803), OR6C70 (ENSG00000184954), OR6C76 (ENSG00000185821), OR6C75 (ENSG00000187857), OR6C6 (ENSG00000188324), OR6M1 (ENSG00000196099), OR6C74 (ENSG00000197706), OR6C68 (ENSG00000205327), OR6C65 (ENSG00000205328), OR6C3 (ENSG00000205329), OR6C1 (ENSG00000205330), OR6X1 (ENSG00000221931), OR6V1 (ENSG00000225781), OR6J1 (ENSG00000255804)

Protein

Protein identifiers

Olfactory receptor 6T1 — Q8NGN1 (reviewed: Q8NGN1)

Alternative names: Olfactory receptor OR11-277

All UniProt accessions (1): Q8NGN1

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005187* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR047132	Olfact_rcpt_6C-like	Family

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGN1-F1	76.29	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

152 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR6T1	FAM221A	A4D161	580
OR6T1	HEATR9	A2RTY3	542
OR6T1	C17orf78	Q8N4C9	540
OR6T1	AMZ1	Q400G9	505
OR6T1	TERB2	Q8NHR7	474
OR6T1	CCDC57	Q2TAC2	462
OR6T1	FASTKD3	Q14CZ7	450
OR6T1	VCX3A	Q9NNX9	444
OR6T1	STK31	Q9BXU1	431
OR6T1	FDCSP	Q8NFU4	418
OR6T1	NKAIN4	Q8IVV8	418
OR6T1	CMYA5	Q8N3K9	408
OR6T1	RDM1	Q8NG50	401
OR6T1	MESP2	Q0VG99	400
OR6T1	KRT75	O95678	391

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR6T1	PSMD11	psi-mi:“MI:0914”(association)	0.350

BioGRID (40): PSMC6 (Affinity Capture-MS), PSMD11 (Affinity Capture-MS), TSPAN10 (Affinity Capture-MS), GUCY1B3 (Affinity Capture-MS), TMEM259 (Affinity Capture-MS), PCYOX1L (Affinity Capture-MS), UBQLN1 (Affinity Capture-MS), EIF2AK3 (Affinity Capture-MS), REEP4 (Affinity Capture-MS), ESYT1 (Affinity Capture-MS), ANKLE2 (Affinity Capture-MS), KCNT2 (Affinity Capture-MS), PKD2 (Affinity Capture-MS), UBQLN4 (Affinity Capture-MS), UBE3A (Affinity Capture-MS)

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NL26, A6NM76, O76001, O76002, O76100, O95007, P0C623, P0C626, P23266, P23267, P23272, P23274, P30953, P30955, P34985, P58173, P59922, P70526, Q13606, Q5TZ20, Q60882, Q60890, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N146, Q8N148, Q8N162, Q8N628, Q8NGA1, Q8NGC5, Q8NGE1, Q8NGE2, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

44 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	42
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

291 predictions. Top by Δscore:

Variant	Effect	Δscore
11:123943601:TGGGA:T	donor_gain	0.9100
11:123943809:TGTTA:T	donor_loss	0.7600
11:123943810:GTTAC:G	donor_loss	0.7600
11:123943811:TTA:T	donor_loss	0.7600
11:123943812:TA:T	donor_loss	0.7600
11:123943813:AC:A	donor_loss	0.7600
11:123943814:C:A	donor_loss	0.7600
11:123943723:GCT:G	acceptor_gain	0.7300
11:123943815:C:A	donor_loss	0.7300
11:123943648:C:CT	acceptor_gain	0.7100
11:123943156:GCCCT:G	acceptor_gain	0.6800
11:123943724:C:A	acceptor_gain	0.6400
11:123943607:C:CT	donor_gain	0.5900
11:123943613:CAG:C	donor_gain	0.5900
11:123943517:C:CC	acceptor_gain	0.5800
11:123943615:G:C	donor_gain	0.5800
11:123943648:C:T	acceptor_gain	0.5800
11:123943662:CAT:C	donor_gain	0.5800
11:123943157:CCCT:C	acceptor_gain	0.5300
11:123943422:A:C	donor_gain	0.5300
11:123943621:A:T	donor_gain	0.5100
11:123943167:A:T	acceptor_gain	0.5000
11:123943244:C:CT	donor_gain	0.5000
11:123943614:AGT:A	donor_gain	0.5000
11:123943159:C:CC	acceptor_gain	0.4900
11:123943155:GGCCC:G	acceptor_gain	0.4500
11:123943155:GGCC:G	acceptor_gain	0.4400
11:123943243:G:C	donor_gain	0.4400
11:123943156:GCC:G	acceptor_gain	0.4300
11:123943157:CCC:C	acceptor_gain	0.4300

AlphaMissense

2090 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:123942969:G:C	F290L	0.781
11:123942969:G:T	F290L	0.781
11:123942971:A:G	F290L	0.781
11:123943335:G:C	F168L	0.768
11:123943335:G:T	F168L	0.768
11:123943337:A:G	F168L	0.768
11:123943125:A:C	F238L	0.724
11:123943125:A:T	F238L	0.724
11:123943127:A:G	F238L	0.724
11:123943803:A:C	F12L	0.711
11:123943803:A:T	F12L	0.711
11:123943805:A:G	F12L	0.711
11:123943788:G:C	F17L	0.710
11:123943788:G:T	F17L	0.710
11:123943790:A:G	F17L	0.710
11:123942975:G:C	F288L	0.685
11:123942975:G:T	F288L	0.685
11:123942977:A:G	F288L	0.685
11:123943308:G:C	F177L	0.672
11:123943308:G:T	F177L	0.672
11:123943310:A:G	F177L	0.672
11:123943755:G:C	F28L	0.644
11:123943755:G:T	F28L	0.644
11:123943757:A:G	F28L	0.644
11:123943503:G:C	F112L	0.642
11:123943503:G:T	F112L	0.642
11:123943505:A:G	F112L	0.642
11:123943068:A:C	F257L	0.636
11:123943068:A:T	F257L	0.636
11:123943070:A:G	F257L	0.636

dbSNP variants (sampled 300 via entrez): RS1003324950 (11:123945789 T>G), RS1003388788 (11:123945284 A>T), RS1003760422 (11:123944837 T>A), RS1004271177 (11:123942690 G>T), RS1005618264 (11:123945579 T>G), RS1006881694 (11:123943947 A>G), RS1007531591 (11:123944266 G>A), RS1007608679 (11:123944934 A>G), RS1007991074 (11:123943887 T>C), RS1009653384 (11:123942603 C>T), RS1009664334 (11:123942836 C>T), RS1012483420 (11:123945176 A>G), RS1012513565 (11:123944241 T>C), RS1018126721 (11:123944972 A>G), RS1018627098 (11:123942841 A>C,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004751_11	Serum uric acid levels in response to allopurinol in gout	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004761	uric acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

9 total (human), top 9 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	3
Benzo(a)pyrene	affects methylation, increases mutagenesis	2
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
bisphenol S	increases methylation	1
Amiodarone	increases expression	1
Cadmium	increases abundance, decreases expression	1
Catechin	increases expression, affects cotreatment	1
Valproic Acid	decreases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.