OR6Y1

Summary

OR6Y1 (olfactory receptor family 6 subfamily Y member 1, HGNC:14823) is a protein-coding gene on chromosome 1q23.1, encoding Olfactory receptor 6Y1 (Q8NGX8). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 391112 — RefSeq curated summary.

At a glance

• GWAS associations: 29
• Clinical variants (ClinVar): 66 total
• MANE Select transcript: NM_001005189

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14823
Approved symbol	OR6Y1
Name	olfactory receptor family 6 subfamily Y member 1
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000197532
Ensembl biotype	protein_coding
Entrez	391112

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641282, ENST00000641622

RefSeq mRNA: 2 — MANE Select: NM_001005189 NM_001005189, NM_001386050

CCDS: CCDS30899

Canonical transcript exons

ENST00000641622 — 2 exons

Exon	Start	End
ENSE00003811946	158554266	158554405
ENSE00003812714	158544550	158549537

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 50.46.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	50.46	gold quality
stromal cell of endometrium	CL:0002255	48.13	gold quality
hindlimb stylopod muscle	UBERON:0004252	44.83	gold quality
calcaneal tendon	UBERON:0003701	42.28	gold quality
monocyte	CL:0000576	41.34	gold quality
leukocyte	CL:0000738	41.28	gold quality
bone marrow	UBERON:0002371	39.97	gold quality
endometrium	UBERON:0001295	37.66	gold quality
granulocyte	CL:0000094	37.61	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
skeletal muscle tissue	UBERON:0001134	36.42	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
primary visual cortex	UBERON:0002436	35.82	gold quality
blood	UBERON:0000178	35.61	gold quality
muscle tissue	UBERON:0002385	35.57	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
cortex of kidney	UBERON:0001225	35.44	gold quality
apex of heart	UBERON:0002098	35.30	gold quality
liver	UBERON:0002107	34.95	gold quality
adrenal tissue	UBERON:0018303	34.88	gold quality
right adrenal gland cortex	UBERON:0035827	34.21	gold quality
muscle of leg	UBERON:0001383	33.97	gold quality
mucosa of transverse colon	UBERON:0004991	33.93	gold quality
right coronary artery	UBERON:0001625	33.77	gold quality
popliteal artery	UBERON:0002250	33.56	gold quality
corpus callosum	UBERON:0002336	33.54	gold quality
tibial artery	UBERON:0007610	33.53	gold quality
gastrocnemius	UBERON:0001388	33.18	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.42
E-MTAB-6678	no	187.17
E-MTAB-7249	no	67.23

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or6p1	ENSMUSG00000051509
rattus_norvegicus	Or6p1	ENSRNOG00000077494

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 6Y1 — Q8NGX8 (reviewed: Q8NGX8)

Alternative names: Olfactory receptor 6Y2, Olfactory receptor OR1-11

All UniProt accessions (1): Q8NGX8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001005189, NP_001372979 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGX8-F1	86.47	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 102–194

Glycosylation sites (2): 10, 191

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, chr1q23

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

170 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR6Y1	TAS2R1	Q9NYW7	289
OR6Y1	TAS1R2	Q8TE23	282
OR6Y1	SCNN1B	P51168	247
OR6Y1	METRNL	Q641Q3	244
OR6Y1	PDE11A	Q9HCR9	225
OR6Y1	VN1R1	Q9GZP7	222
OR6Y1	PDE1A	P54750	213
OR6Y1	GALNT3	Q14435	201
OR6Y1	RIC8B	Q9NVN3	195
OR6Y1	SPTA1	P02549	195
OR6Y1	MRGPRX3	Q96LB0	185
OR6Y1	PKD2L1	Q9P0L9	170
OR6Y1	DLX1	P56177	170
OR6Y1	KCNK17	Q96T54	169
OR6Y1	MRGPRE	Q86SM8	167

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A4D2G3, O43749, O76001, O76002, O76100, O95006, P0DMU2, P23266, P23269, P23272, P23274, P30953, P30955, P58173, P59922, P70526, Q13607, Q15619, Q60890, Q6UXT6, Q8N148, Q8N628, Q8NGA6, Q8NGL2, Q8NGS0, Q8NGS2, Q8NGX8, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NH04, Q8VGI1, Q8VGK5, Q8VGR9, Q95156, Q96R09, Q96R47, Q96R48, Q96R84, Q9GZK6

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

370 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158547449:C:CT	acceptor_gain	0.8000
1:158547164:T:TA	donor_gain	0.7300
1:158547330:A:C	acceptor_gain	0.6700
1:158547255:G:GC	acceptor_gain	0.6600
1:158547330:A:AC	acceptor_gain	0.6500
1:158547519:T:TA	donor_gain	0.6500
1:158547348:A:AC	donor_gain	0.6400
1:158547349:C:CC	donor_gain	0.6400
1:158547204:T:TA	donor_gain	0.6300
1:158547409:T:TA	donor_gain	0.6300
1:158547618:A:C	donor_gain	0.6200
1:158547349:CGA:C	donor_gain	0.6000
1:158547507:G:GA	donor_gain	0.6000
1:158547650:T:TA	donor_gain	0.6000
1:158547131:A:C	donor_gain	0.5900
1:158547150:C:A	donor_gain	0.5900
1:158547253:CAG:C	acceptor_gain	0.5800
1:158547314:A:C	acceptor_gain	0.5800
1:158547653:T:TA	donor_gain	0.5800
1:158547138:AAAGC:A	donor_gain	0.5700
1:158547551:A:AC	donor_gain	0.5700
1:158547875:C:CT	donor_gain	0.5700
1:158547132:C:CT	donor_gain	0.5600
1:158547133:T:TT	donor_gain	0.5600
1:158547329:CA:C	acceptor_gain	0.5600
1:158547393:C:CA	donor_gain	0.5600
1:158548086:T:TA	donor_gain	0.5600
1:158547201:A:AC	donor_gain	0.5500
1:158547202:C:CC	donor_gain	0.5500
1:158547254:A:T	acceptor_gain	0.5500

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000140900 (1:158546811 G>A), RS1000257304 (1:158546547 TG>T), RS1000482095 (1:158552269 T>A,G), RS1000580024 (1:158554347 T>C), RS1000703733 (1:158553655 A>G), RS1001245565 (1:158551769 C>A,T), RS1001478783 (1:158546103 T>C,G), RS1001632990 (1:158551601 C>T), RS1002254582 (1:158552944 T>A), RS1002260911 (1:158548930 A>G), RS1002486741 (1:158550590 A>G,T), RS1002694914 (1:158546888 A>C), RS1003061531 (1:158550227 T>G), RS1003098819 (1:158544856 G>C), RS1003355955 (1:158550064 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

29 associations (top):

Study	Trait	p-value
GCST001765_34	Red blood cell traits	4.000000e-16
GCST007997_1	Obesity (extreme) (SNP x SNP interaction)	1.000000e-08
GCST007997_10	Obesity (extreme) (SNP x SNP interaction)	4.000000e-10
GCST007997_13	Obesity (extreme) (SNP x SNP interaction)	3.000000e-09
GCST007997_14	Obesity (extreme) (SNP x SNP interaction)	2.000000e-09
GCST007997_15	Obesity (extreme) (SNP x SNP interaction)	9.000000e-10
GCST007997_16	Obesity (extreme) (SNP x SNP interaction)	3.000000e-10
GCST007997_17	Obesity (extreme) (SNP x SNP interaction)	5.000000e-10
GCST007997_18	Obesity (extreme) (SNP x SNP interaction)	9.000000e-10
GCST007997_2	Obesity (extreme) (SNP x SNP interaction)	9.000000e-08
GCST007997_22	Obesity (extreme) (SNP x SNP interaction)	2.000000e-09
GCST007997_23	Obesity (extreme) (SNP x SNP interaction)	1.000000e-09
GCST007997_24	Obesity (extreme) (SNP x SNP interaction)	7.000000e-10
GCST007997_25	Obesity (extreme) (SNP x SNP interaction)	2.000000e-10
GCST007997_26	Obesity (extreme) (SNP x SNP interaction)	4.000000e-10
GCST007997_3	Obesity (extreme) (SNP x SNP interaction)	2.000000e-08
GCST007997_31	Obesity (extreme) (SNP x SNP interaction)	3.000000e-10
GCST007997_32	Obesity (extreme) (SNP x SNP interaction)	2.000000e-10
GCST007997_33	Obesity (extreme) (SNP x SNP interaction)	9.000000e-11
GCST007997_34	Obesity (extreme) (SNP x SNP interaction)	3.000000e-11
GCST007997_35	Obesity (extreme) (SNP x SNP interaction)	7.000000e-11
GCST007997_36	Obesity (extreme) (SNP x SNP interaction)	9.000000e-11
GCST007997_4	Obesity (extreme) (SNP x SNP interaction)	3.000000e-08
GCST007997_5	Obesity (extreme) (SNP x SNP interaction)	1.000000e-09
GCST007997_6	Obesity (extreme) (SNP x SNP interaction)	8.000000e-10
GCST007997_7	Obesity (extreme) (SNP x SNP interaction)	4.000000e-10
GCST007997_8	Obesity (extreme) (SNP x SNP interaction)	1.000000e-10
GCST007997_9	Obesity (extreme) (SNP x SNP interaction)	3.000000e-10
GCST90002404_432	Red cell distribution width	4.000000e-19

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0009188	Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression, increases abundance	1
Copper	affects cotreatment, decreases expression	1
Folic Acid	increases expression	1
Sodium Selenite	decreases expression	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.