OR7A10

Summary

OR7A10 (olfactory receptor family 7 subfamily A member 10, HGNC:8356) is a protein-coding gene on chromosome 19p13.12, encoding Olfactory receptor 7A10 (O76100). Odorant receptor. It is a selective cancer dependency (DepMap: 12.2% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390892 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 41 total
• Cancer dependency (DepMap): dependent in 12.2% of screened cell lines
• MANE Select transcript: NM_001005190

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8356
Approved symbol	OR7A10
Name	olfactory receptor family 7 subfamily A member 10
Location	19p13.12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000127515
Ensembl biotype	protein_coding
Entrez	390892

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641129

RefSeq mRNA: 1 — MANE Select: NM_001005190 NM_001005190

CCDS: CCDS32936

Canonical transcript exons

ENST00000641129 — 2 exons

Exon	Start	End
ENSE00003811925	14840466	14841889
ENSE00003813518	14848500	14848922

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 71.31.

Top tissues by expression

278 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cervix squamous epithelium	UBERON:0006922	71.31	gold quality
tongue squamous epithelium	UBERON:0006919	69.11	gold quality
olfactory bulb	UBERON:0002264	68.83	gold quality
hair follicle	UBERON:0002073	64.21	gold quality
type B pancreatic cell	CL:0000169	64.01	gold quality
epithelial cell of pancreas	CL:0000083	63.24	gold quality
cardiac muscle of right atrium	UBERON:0003379	59.59	gold quality
left ventricle myocardium	UBERON:0006566	58.90	gold quality
pancreatic ductal cell	CL:0002079	58.01	silver quality
diaphragm	UBERON:0001103	56.51	gold quality
lower lobe of lung	UBERON:0008949	56.20	silver quality
vastus lateralis	UBERON:0001379	56.17	gold quality
quadriceps femoris	UBERON:0001377	55.68	gold quality
myocardium	UBERON:0002349	55.30	gold quality
cervix epithelium	UBERON:0004801	55.16	gold quality
thymus	UBERON:0002370	54.44	gold quality
palpebral conjunctiva	UBERON:0001812	54.21	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	53.72	gold quality
inferior olivary complex	UBERON:0002127	53.47	gold quality
nasal cavity epithelium	UBERON:0005384	52.59	gold quality
oocyte	CL:0000023	52.01	gold quality
oral cavity	UBERON:0000167	51.93	gold quality
oviduct epithelium	UBERON:0004804	51.82	gold quality
kidney epithelium	UBERON:0004819	50.19	gold quality
Brodmann (1909) area 46	UBERON:0006483	49.81	gold quality
blood vessel layer	UBERON:0004797	49.29	gold quality
choroid plexus epithelium	UBERON:0003911	48.89	gold quality
deltoid	UBERON:0001476	48.87	gold quality
CA1 field of hippocampus	UBERON:0003881	48.50	gold quality
orbitofrontal cortex	UBERON:0004167	48.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.30

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 12.2% of screened cell lines.

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or7a36	ENSMUSG00000046493
mus_musculus	Or7a40	ENSMUSG00000048101
mus_musculus	Or7a42	ENSMUSG00000094080
mus_musculus	Or7a38	ENSMUSG00000094673
rattus_norvegicus	Or7a38d	ENSRNOG00000073775
rattus_norvegicus	Or7a36	ENSRNOG00000086119
rattus_norvegicus	Or7a38e	ENSRNOG00000091284

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 7A10 — O76100 (reviewed: O76100)

Alternative names: OST027, Olfactory receptor OR19-18

All UniProt accessions (2): O76100, A0A126GVC8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005190* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O76100-F1	87.87	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 25 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, PRC2_SUZ12_UP.V1_UP, BRCA1_DN.V1_DN, KRAS.KIDNEY_UP.V1_DN, GLI1_TARGET_GENES

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

206 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR7A10	POPDC3	Q9HBV1	480
OR7A10	COL21A1	Q96P44	380
OR7A10	COL27A1	Q8IZC6	351
OR7A10	COL9A3	Q14050	340
OR7A10	COL5A3	P25940	322
OR7A10	PRAME	P78395	305
OR7A10	COL7A1	Q02388	300
OR7A10	DEFB103A	P81534	247
OR7A10	COL6A3	P12111	243
OR7A10	COL11A1	P12107	240
OR7A10	CTIF	O43310	224
OR7A10	KCNMB3	Q9NPA1	222
OR7A10	TGFBI	Q15582	211
OR7A10	EDNRA	P25101	201
OR7A10	PPIA	P05092	191

IntAct

7 interactions, top by confidence:

A	B	Type	Score
OR7A10	SDHA	psi-mi:“MI:0915”(physical association)	0.400
OR7A10	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	OR7A10	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (3): OR7A10 (Affinity Capture-MS), SDHA (Proximity Label-MS), OR7A10 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NL26, A6NM76, O76001, O76002, O76100, O95007, P0C623, P0C626, P23266, P23267, P23272, P23274, P30953, P30955, P34985, P58173, P59922, P70526, Q13606, Q5TZ20, Q60882, Q60890, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N146, Q8N148, Q8N162, Q8N628, Q8NGA1, Q8NGC5, Q8NGE1, Q8NGE2, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

41 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

275 predictions. Top by Δscore:

Variant	Effect	Δscore
19:14841577:T:TA	donor_gain	0.8800
19:14841670:C:CT	donor_gain	0.8500
19:14841671:T:TT	donor_gain	0.8500
19:14841589:AG:A	donor_gain	0.8400
19:14841590:G:GA	donor_gain	0.8200
19:14841575:CAT:C	donor_gain	0.7800
19:14841178:T:TA	donor_gain	0.7700
19:14841627:T:C	donor_gain	0.7700
19:14841577:T:C	donor_gain	0.7300
19:14841640:TCGGG:T	donor_gain	0.7300
19:14841700:A:AC	donor_gain	0.7300
19:14841701:C:CC	donor_gain	0.7300
19:14841576:A:C	donor_gain	0.7100
19:14841819:T:TA	donor_gain	0.7000
19:14841702:A:C	donor_gain	0.6900
19:14841633:A:T	donor_gain	0.6800
19:14841763:CAG:C	donor_gain	0.6800
19:14841548:CAATC:C	acceptor_gain	0.6700
19:14841603:A:AC	donor_gain	0.6700
19:14841777:A:C	donor_gain	0.6700
19:14841571:A:C	donor_gain	0.6600
19:14841640:T:TA	donor_gain	0.6600
19:14841765:G:C	donor_gain	0.6600
19:14841672:A:AC	donor_gain	0.6500
19:14841673:C:CC	donor_gain	0.6500
19:14841767:G:T	donor_gain	0.6500
19:14841551:TC:T	acceptor_gain	0.6400
19:14841552:CC:C	acceptor_gain	0.6400
19:14841629:C:T	donor_gain	0.6300
19:14841770:CAGG:C	donor_gain	0.6300

AlphaMissense

2023 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:14841842:A:C	F12L	0.903
19:14841842:A:T	F12L	0.903
19:14841844:A:G	F12L	0.903
19:14841524:C:A	M118I	0.838
19:14841524:C:G	M118I	0.838
19:14841524:C:T	M118I	0.838
19:14841005:A:C	S291R	0.829
19:14841005:A:T	S291R	0.829
19:14841007:T:G	S291R	0.829
19:14841374:A:C	F168L	0.822
19:14841374:A:T	F168L	0.822
19:14841376:A:G	F168L	0.822
19:14841347:A:C	F177L	0.810
19:14841347:A:T	F177L	0.810
19:14841349:A:G	F177L	0.810
19:14841164:A:C	F238L	0.809
19:14841164:A:T	F238L	0.809
19:14841166:A:G	F238L	0.809
19:14841785:G:C	F31L	0.804
19:14841785:G:T	F31L	0.804
19:14841787:A:G	F31L	0.804
19:14841125:A:C	F251L	0.801
19:14841125:A:T	F251L	0.801
19:14841127:A:G	F251L	0.801
19:14841509:A:C	F123L	0.800
19:14841509:A:T	F123L	0.800
19:14841511:A:G	F123L	0.800
19:14841513:C:G	R122P	0.794
19:14841752:G:C	N42K	0.784
19:14841752:G:T	N42K	0.784

dbSNP variants (sampled 300 via entrez): RS1000070090 (19:14844991 C>T), RS1000230791 (19:14842665 C>A), RS1000281515 (19:14842504 G>T), RS1000590078 (19:14845695 A>G,T), RS1000619464 (19:14845888 A>G), RS1000745940 (19:14847606 G>A), RS1001096247 (19:14847294 T>C), RS1001558408 (19:14847155 T>G), RS1001632203 (19:14846875 T>C,G), RS1001946308 (19:14846446 T>A), RS1002181515 (19:14841916 G>A,C), RS1002949274 (19:14847743 C>T), RS1003235542 (19:14845970 C>A,G,T), RS1003888425 (19:14840910 G>C,T), RS1004268570 (19:14840689 T>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010397_1	Gut microbiota (bacterial taxa, rank normal transformation method)	7.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
propionaldehyde	decreases expression	1
CGP 52608	affects binding, increases reaction	1
Arsenic	affects methylation	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.