OR7A17

Summary

OR7A17 (olfactory receptor family 7 subfamily A member 17, HGNC:8363) is a protein-coding gene on chromosome 19p13.12, encoding Olfactory receptor 7A17 (O14581). Odorant receptor. It is a selective cancer dependency (DepMap: 24.4% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26333 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 53 total
• Cancer dependency (DepMap): dependent in 24.4% of screened cell lines
• MANE Select transcript: NM_030901

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8363
Approved symbol	OR7A17
Name	olfactory receptor family 7 subfamily A member 17
Location	19p13.12
Locus type	gene with protein product
Status	Approved
Aliases	HTPCRX19
Ensembl gene	ENSG00000185385
Ensembl biotype	protein_coding
Entrez	26333

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641113, ENST00000642123

RefSeq mRNA: 1 — MANE Select: NM_030901 NM_030901

CCDS: CCDS12319

Canonical transcript exons

ENST00000641113 — 3 exons

Exon	Start	End
ENSE00003812396	14881774	14881871
ENSE00003813469	14878203	14881551
ENSE00003813914	14885941	14886132

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 52.83.

Top tissues by expression

231 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	52.83	silver quality
tendon of biceps brachii	UBERON:0008188	52.68	gold quality
endothelial cell	CL:0000115	51.39	gold quality
buccal mucosa cell	CL:0002336	51.35	gold quality
colonic epithelium	UBERON:0000397	45.16	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
oviduct epithelium	UBERON:0004804	43.21	gold quality
amniotic fluid	UBERON:0000173	43.00	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
bone marrow cell	CL:0002092	42.36	gold quality
skin of hip	UBERON:0001554	41.69	silver quality
vastus lateralis	UBERON:0001379	41.41	gold quality
quadriceps femoris	UBERON:0001377	41.37	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
skeletal muscle tissue	UBERON:0001134	41.19	gold quality
upper leg skin	UBERON:0004262	41.13	silver quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
muscle tissue	UBERON:0002385	40.69	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
epithelium of nasopharynx	UBERON:0001951	40.45	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
germinal epithelium of ovary	UBERON:0001304	40.33	gold quality
esophagus squamous epithelium	UBERON:0006920	40.29	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	40.27	gold quality
jejunum	UBERON:0002115	40.18	gold quality
cartilage tissue	UBERON:0002418	40.06	gold quality
cortical plate	UBERON:0005343	40.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.04

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 24.4% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• Olfactory Receptor OR7A17 Expression Correlates with All-Trans Retinoic Acid (ATRA)-Induced Suppression of Proliferation in Human Keratinocyte Cells. (PMID:34830183)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or7a36	ENSMUSG00000046493
mus_musculus	Or7a40	ENSMUSG00000048101
mus_musculus	Or7a42	ENSMUSG00000094080
mus_musculus	Or7a38	ENSMUSG00000094673
rattus_norvegicus	Or7a38d	ENSRNOG00000073775
rattus_norvegicus	Or7a36	ENSRNOG00000086119
rattus_norvegicus	Or7a38e	ENSRNOG00000091284

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 7A17 — O14581 (reviewed: O14581)

All UniProt accessions (2): A0A126GVR5, O14581

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_112163* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14581-F1	85.47	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 37 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, IL15_UP.V1_DN, TGFB_UP.V1_DN, ZNF781_TARGET_GENES

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

106 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR7A17	SCART1	Q4G0T1	479
OR7A17	KIF26A	Q9ULI4	370
OR7A17	COL21A1	Q96P44	311
OR7A17	PRR7	Q8TB68	303
OR7A17	NALCN	Q8IZF0	293
OR7A17	TRIM52	Q96A61	289
OR7A17	BTNL9	Q6UXG8	285
OR7A17	LMAN2	Q12907	279
OR7A17	FAF2	Q96CS3	272
OR7A17	KDM3B	Q7LBC6	270
OR7A17	COL9A3	Q14050	269
OR7A17	COL5A3	P25940	251
OR7A17	TRIM41	Q8WV44	247
OR7A17	B4GALT7	Q9UBV7	238
OR7A17	COL7A1	Q02388	226

IntAct

13 interactions, top by confidence:

A	B	Type	Score
CYSRT1	OR7A17	psi-mi:“MI:0915”(physical association)	0.560
OR7A17	KRTAP11-1	psi-mi:“MI:0915”(physical association)	0.560
OR7A17	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	OR7A17	psi-mi:“MI:0915”(physical association)	0.370
OR7A17	ACTB	psi-mi:“MI:0914”(association)	0.350
OR7A17	CYSRT1	psi-mi:“MI:0915”(physical association)	0.000
OR7A17	KRTAP11-1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (5): OR7A17 (Two-hybrid), CYSRT1 (Two-hybrid), ACTC1 (Affinity Capture-MS), ACTB (Affinity Capture-MS), OR7A17 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

246 predictions. Top by Δscore:

Variant	Effect	Δscore
19:14880762:C:A	donor_gain	0.7400
19:14881426:A:AC	donor_gain	0.6800
19:14881427:C:CC	donor_gain	0.6800
19:14881427:CT:C	donor_gain	0.6700
19:14880656:T:TA	donor_gain	0.6600
19:14880594:C:CT	acceptor_gain	0.6500
19:14880592:CCCG:C	acceptor_gain	0.6400
19:14880594:C:T	acceptor_gain	0.6400
19:14880582:CACAC:C	acceptor_gain	0.6300
19:14880595:G:C	acceptor_gain	0.6200
19:14880584:CAC:C	acceptor_gain	0.6100
19:14880593:CCG:C	acceptor_gain	0.6100
19:14880595:G:GC	acceptor_gain	0.6000
19:14881068:G:GA	donor_gain	0.6000
19:14880599:A:T	acceptor_gain	0.5900
19:14881055:T:C	donor_gain	0.5900
19:14881180:A:C	donor_gain	0.5900
19:14880595:G:T	acceptor_gain	0.5800
19:14880761:T:TA	donor_gain	0.5800
19:14880657:C:A	donor_gain	0.5600
19:14880601:C:CT	acceptor_gain	0.5400
19:14881055:T:TA	donor_gain	0.5400
19:14880731:C:CT	donor_gain	0.5300
19:14881408:A:C	donor_gain	0.5300
19:14880484:C:CC	acceptor_gain	0.5100
19:14880838:T:TA	donor_gain	0.5100
19:14881031:C:T	acceptor_gain	0.5000
19:14881405:T:C	donor_gain	0.5000
19:14880583:ACACC:A	acceptor_loss	0.4800
19:14880584:CACCT:C	acceptor_loss	0.4800

AlphaMissense

2012 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:14881320:A:C	F12L	0.872
19:14881320:A:T	F12L	0.872
19:14881322:A:G	F12L	0.872
19:14880852:G:C	F168L	0.852
19:14880852:G:T	F168L	0.852
19:14880854:A:G	F168L	0.852
19:14881002:C:A	M118I	0.851
19:14881002:C:G	M118I	0.851
19:14881002:C:T	M118I	0.851
19:14880825:A:C	F177L	0.819
19:14880825:A:T	F177L	0.819
19:14880827:A:G	F177L	0.819
19:14880483:A:C	S291R	0.816
19:14880483:A:T	S291R	0.816
19:14880485:T:G	S291R	0.816
19:14880991:C:G	R122P	0.815
19:14880603:A:C	F251L	0.812
19:14880603:A:T	F251L	0.812
19:14880605:A:G	F251L	0.812
19:14881263:A:C	F31L	0.809
19:14881263:A:T	F31L	0.809
19:14881265:A:G	F31L	0.809
19:14880642:A:C	F238L	0.797
19:14880642:A:T	F238L	0.797
19:14880644:A:G	F238L	0.797
19:14881230:A:C	N42K	0.787
19:14881230:A:T	N42K	0.787
19:14880648:C:A	K236N	0.775
19:14880648:C:G	K236N	0.775
19:14880993:A:C	D121E	0.768

dbSNP variants (sampled 300 via entrez): RS1000035896 (19:14882288 G>T), RS1000706317 (19:14879752 C>T), RS1000736671 (19:14884207 GA>G,GAA), RS1000815249 (19:14878517 C>A), RS1001073518 (19:14884044 C>T), RS1001579944 (19:14884585 T>C), RS1001752483 (19:14879473 C>T), RS1001941557 (19:14884636 C>T), RS1002309028 (19:14884364 G>A,T), RS1002696916 (19:14887046 T>A), RS1002909036 (19:14885697 C>A), RS1003357674 (19:14878294 C>T), RS1003429671 (19:14877950 C>T), RS1004360480 (19:14878402 T>A,C), RS1004494049 (19:14887862 T>C,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST008114_16	Type 2 diabetes	5.000000e-06
GCST008748_11	Epigenetic age acceleration in alcohol use disorder	9.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0000473	epigenetic status
EFO:0022597	aging

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	increases reaction, affects binding	1
Resveratrol	decreases expression, affects cotreatment	1
Fulvestrant	increases methylation	1
Benzo(a)pyrene	increases methylation	1
Copper	affects cotreatment, decreases expression	1
Aflatoxin B1	increases methylation	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.