OR7A5

Summary

OR7A5 (olfactory receptor family 7 subfamily A member 5, HGNC:8368) is a protein-coding gene on chromosome 19p13.1, encoding Olfactory receptor 7A5 (Q15622). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26659 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_017506

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8368
Approved symbol	OR7A5
Name	olfactory receptor family 7 subfamily A member 5
Location	19p13.1
Locus type	gene with protein product
Status	Approved
Aliases	HTPCR2
Ensembl gene	ENSG00000188269
Ensembl biotype	protein_coding
Entrez	26659

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000322301, ENST00000594432

RefSeq mRNA: 5 — MANE Select: NM_017506 NM_001370480, NM_001370481, NM_001370482, NM_001370483, NM_017506

CCDS: CCDS12318

Canonical transcript exons

ENST00000322301 — 2 exons

Exon	Start	End
ENSE00002975689	14835074	14835185
ENSE00003813297	14826241	14828254

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 73.00.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3720 / max 59.7276, expressed in 88 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179684	0.4442	102
179683	0.3154	82
179682	0.0567	24

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
inferior olivary complex	UBERON:0002127	73.00	gold quality
mucosa of paranasal sinus	UBERON:0005030	72.75	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	70.42	gold quality
mucosa of urinary bladder	UBERON:0001259	64.88	gold quality
superficial temporal artery	UBERON:0001614	63.78	gold quality
cranial nerve II	UBERON:0000941	63.08	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	61.62	gold quality
corpus epididymis	UBERON:0004359	61.21	gold quality
CA1 field of hippocampus	UBERON:0003881	60.55	gold quality
substantia nigra	UBERON:0002038	60.09	gold quality
spinal cord	UBERON:0002240	59.55	gold quality
midbrain	UBERON:0001891	58.49	gold quality
pituitary gland	UBERON:0000007	57.73	gold quality
adenohypophysis	UBERON:0002196	57.17	gold quality
decidua	UBERON:0002450	56.55	gold quality
caput epididymis	UBERON:0004358	56.00	gold quality
lower lobe of lung	UBERON:0008949	55.39	silver quality
vastus lateralis	UBERON:0001379	54.95	gold quality
quadriceps femoris	UBERON:0001377	54.52	gold quality
skin of leg	UBERON:0001511	54.45	gold quality
epithelium of mammary gland	UBERON:0003244	54.17	gold quality
mammary duct	UBERON:0001765	54.07	gold quality
gingival epithelium	UBERON:0001949	53.40	gold quality
vena cava	UBERON:0004087	53.27	gold quality
inferior vagus X ganglion	UBERON:0005363	52.97	silver quality
medial globus pallidus	UBERON:0002477	52.71	silver quality
buccal mucosa cell	CL:0002336	52.66	silver quality
male germ cell	CL:0000015	52.57	gold quality
sperm	CL:0000019	52.47	gold quality
hair follicle	UBERON:0002073	52.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.94

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

55 targeting OR7A5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-202-3P	99.84	71.41	1290
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-548A-3P	99.76	70.58	3524
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-9851-3P	99.63	69.68	1110
HSA-MIR-5003-5P	99.61	69.13	1624
HSA-MIR-4480	99.42	66.02	735
HSA-MIR-4318	99.38	66.94	1505

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or7a36	ENSMUSG00000046493
mus_musculus	Or7a40	ENSMUSG00000048101
mus_musculus	Or7a42	ENSMUSG00000094080
mus_musculus	Or7a38	ENSMUSG00000094673
rattus_norvegicus	Or7a38d	ENSRNOG00000073775
rattus_norvegicus	Or7a36	ENSRNOG00000086119
rattus_norvegicus	Or7a38e	ENSRNOG00000091284

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 7A5 — Q15622 (reviewed: Q15622)

Alternative names: Olfactory receptor OR19-17, Olfactory receptor TPCR92

All UniProt accessions (2): A0A126GW60, Q15622

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (5): NP_001357409, NP_001357410, NP_001357411, NP_001357412, NP_059976* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q15622-F1	85.95	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 53 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, MORF_CTSB, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, MORF_MAP2K7, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, JNK_DN.V1_DN, KMT2D_TARGET_GENES

GO Biological Process (5): signal transduction (GO:0007165), sensory perception of smell (GO:0007608), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of chemical stimulus (GO:0007606), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of chemical stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

192 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR7A5	RNF175	Q8N4F7	370
OR7A5	RNPEPL1	Q9HAU8	352
OR7A5	VN1R1	Q9GZP7	350
OR7A5	CNGA2	Q16280	321
OR7A5	F2RL2	O00254	284
OR7A5	ANO2	Q9NQ90	256
OR7A5	ADCY3	O60266	254
OR7A5	CNGA4	Q8IV77	245
OR7A5	ADCY8	P40145	228
OR7A5	OMP	P47874	227
OR7A5	MRGPRX3	Q96LB0	225
OR7A5	MND1	Q9BWT6	224
OR7A5	GNG13	Q9P2W3	224
OR7A5	GNG8	Q9UK08	220
OR7A5	QRFPR	Q96P65	220

IntAct

7 interactions, top by confidence:

A	B	Type	Score
OR7A5	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	OR7A5	psi-mi:“MI:0915”(physical association)	0.370
OR7A5	UBE4B	psi-mi:“MI:0914”(association)	0.350

BioGRID (6): SLC25A42 (Affinity Capture-MS), KIAA1549 (Affinity Capture-MS), UBL7 (Affinity Capture-MS), GADL1 (Affinity Capture-MS), UBE4B (Affinity Capture-MS), APP (Reconstituted Complex)

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

404 predictions. Top by Δscore:

Variant	Effect	Δscore
19:14828255:C:CC	acceptor_gain	0.9900
19:14828251:GTGA:G	acceptor_gain	0.9800
19:14828252:TGA:T	acceptor_gain	0.9800
19:14828259:C:CT	acceptor_gain	0.9800
19:14829562:A:T	acceptor_gain	0.9800
19:14835069:CTCA:C	donor_loss	0.9800
19:14835070:TCA:T	donor_loss	0.9800
19:14835071:CA:C	donor_loss	0.9800
19:14835073:C:G	donor_loss	0.9800
19:14828250:AGTGA:A	acceptor_gain	0.9700
19:14828253:GA:G	acceptor_gain	0.9700
19:14835068:ACT:A	donor_loss	0.9700
19:14835072:A:AC	donor_gain	0.9700
19:14835073:C:CC	donor_gain	0.9700
19:14828260:A:T	acceptor_gain	0.9600
19:14833976:CAGG:C	donor_gain	0.9500
19:14835067:AACTC:A	donor_loss	0.9500
19:14828253:GAC:G	acceptor_loss	0.9400
19:14828254:AC:A	acceptor_loss	0.9400
19:14828256:T:A	acceptor_loss	0.9400
19:14835101:T:TA	donor_gain	0.9400
19:14833317:A:T	acceptor_gain	0.9300
19:14833316:C:CT	acceptor_gain	0.9200
19:14830452:G:T	donor_gain	0.8900
19:14833312:C:G	acceptor_gain	0.8600
19:14834926:A:AC	donor_gain	0.8600
19:14833975:A:AC	donor_gain	0.8500
19:14833976:C:CC	donor_gain	0.8500
19:14834948:A:AC	donor_gain	0.8400
19:14835066:CAACT:C	donor_loss	0.8400

AlphaMissense

2079 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:14827738:G:C	F168L	0.895
19:14827738:G:T	F168L	0.895
19:14827740:A:G	F168L	0.895
19:14828206:A:C	F12L	0.890
19:14828206:A:T	F12L	0.890
19:14828208:A:G	F12L	0.890
19:14827711:A:C	F177L	0.833
19:14827711:A:T	F177L	0.833
19:14827713:A:G	F177L	0.833
19:14827888:C:A	M118I	0.815
19:14827888:C:G	M118I	0.815
19:14827888:C:T	M118I	0.815
19:14827877:C:G	R122P	0.812
19:14828149:G:C	F31L	0.804
19:14828149:G:T	F31L	0.804
19:14828151:A:G	F31L	0.804
19:14827369:A:C	S291R	0.803
19:14827369:A:T	S291R	0.803
19:14827371:T:G	S291R	0.803
19:14827873:A:C	F123L	0.788
19:14827873:A:T	F123L	0.788
19:14827875:A:G	F123L	0.788
19:14827489:A:C	F251L	0.779
19:14827489:A:T	F251L	0.779
19:14827491:A:G	F251L	0.779
19:14828116:G:C	N42K	0.778
19:14828116:G:T	N42K	0.778
19:14827534:C:A	K236N	0.774
19:14827534:C:G	K236N	0.774
19:14827797:A:G	W149R	0.769

dbSNP variants (sampled 300 via entrez): RS1000244047 (19:14835080 G>A), RS1000554452 (19:14825888 C>T), RS1000751571 (19:14828985 C>A,T), RS1000895993 (19:14832715 G>A), RS1001238942 (19:14836726 A>G), RS1001268630 (19:14837047 A>G), RS1001274590 (19:14827164 A>G), RS1001895229 (19:14831395 C>G), RS1002040213 (19:14835564 C>T), RS1002349190 (19:14826393 G>A), RS1002376372 (19:14826691 A>G), RS1002484926 (19:14832637 G>C), RS1002718664 (19:14831032 G>A), RS1002862402 (19:14832416 T>C), RS1002909160 (19:14835180 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases methylation, increases expression	2
incobotulinumtoxinA	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.