OR7D4

Summary

OR7D4 (olfactory receptor family 7 subfamily D member 4, HGNC:8380) is a protein-coding gene on chromosome 19p13.2, encoding Olfactory receptor 7D4 (Q8NG98). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 125958 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_001005191

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8380
Approved symbol	OR7D4
Name	olfactory receptor family 7 subfamily D member 4
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	hg105, OR19-B
Ensembl gene	ENSG00000174667
Ensembl biotype	protein_coding
OMIM	611538
Entrez	125958

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000308682, ENST00000641244, ENST00000641669

RefSeq mRNA: 1 — MANE Select: NM_001005191 NM_001005191

CCDS: CCDS32901

Canonical transcript exons

ENST00000641669 — 2 exons

Exon	Start	End
ENSE00003813804	9210276	9214850
ENSE00003814226	9219200	9219589

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 51.02.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	51.02	gold quality
stromal cell of endometrium	CL:0002255	47.78	gold quality
ventricular zone	UBERON:0003053	43.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	41.96	gold quality
colonic epithelium	UBERON:0000397	41.22	gold quality
ganglionic eminence	UBERON:0004023	40.78	silver quality
cortical plate	UBERON:0005343	39.80	gold quality
bone marrow	UBERON:0002371	38.89	gold quality
monocyte	CL:0000576	38.49	gold quality
leukocyte	CL:0000738	38.09	gold quality
calcaneal tendon	UBERON:0003701	37.55	gold quality
skeletal muscle tissue	UBERON:0001134	37.34	gold quality
granulocyte	CL:0000094	37.26	gold quality
muscle tissue	UBERON:0002385	37.24	gold quality
blood	UBERON:0000178	36.57	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
cortex of kidney	UBERON:0001225	35.07	silver quality
liver	UBERON:0002107	34.85	gold quality
superior frontal gyrus	UBERON:0002661	34.79	gold quality
urinary bladder	UBERON:0001255	34.41	gold quality
mucosa of transverse colon	UBERON:0004991	33.78	gold quality
adrenal tissue	UBERON:0018303	33.37	gold quality
endometrium	UBERON:0001295	33.27	gold quality
lymph node	UBERON:0000029	33.17	gold quality
mucosa of stomach	UBERON:0001199	32.59	gold quality
smooth muscle tissue	UBERON:0001135	32.50	gold quality
placenta	UBERON:0001987	32.27	gold quality
myometrium	UBERON:0001296	32.08	gold quality
prefrontal cortex	UBERON:0000451	31.77	gold quality
muscle of leg	UBERON:0001383	31.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Genotypic variation in OR7D4 accounts for a significant proportion of the valence (pleasantness or unpleasantness) and intensity variance in perception of these steroidal odours (PMID:17873857)
• The results suggested that odor perception between heterosexual partners may have an impact on the development of depression and anxiety, and that it might be influenced by genetic variation in OR7D4. (PMID:21093532)
• This study suggested that OR7D4 sequence variant (rs2878329 G>A) showed evidence of association with reduced levels of adiposity (p=0.03), cognitive dietary restraint (p=0.05) and susceptibility to hunger (p=0.008). (PMID:22044667)
• Data is consistent with the idea that OR7D4 genotype predicts the sensory perception of meat containing androstenone and that genetic variation in an odorant receptor can alter food preferences. (PMID:22567099)
• results suggest non-neutral evolution for an olfactory receptor gene (PMID:26072518)
• Impact of genotypic variations of the androstadienone (AND)-receptor OR7D4, as well as the influence of participant sex and concomitant hormonal fluctuations on AND-action during emotional interference processing, olfactory performance and mood assessments. (PMID:29246659)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or7d11	ENSMUSG00000044454
mus_musculus	Or7d10	ENSMUSG00000051118
mus_musculus	Or7d9	ENSMUSG00000059623
rattus_norvegicus	Or7d10	ENSRNOG00000030569
rattus_norvegicus		ENSRNOG00000073248
rattus_norvegicus	Or7d11c	ENSRNOG00000077229
rattus_norvegicus	Or7d9	ENSRNOG00000088878

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 7D4 — Q8NG98 (reviewed: Q8NG98)

Alternative names: OR19-B, Odorant receptor family subfamily D member 4RT, Olfactory receptor OR19-7

All UniProt accessions (2): Q8NG98, A0A126GVR1

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

Subcellular location. Cell membrane.

Tissue specificity. Nasal olfactory epithelium.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005191* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (32 total): sequence variant 14, topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NG98-F1	88.11	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, PEDRIOLI_MIR31_TARGETS_UP, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

440 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR7D4	TAS2R60	P59551	447
OR7D4	VN1R1	Q9GZP7	441
OR7D4	TAAR5	O14804	436
OR7D4	SSTR2	P30874	413
OR7D4	FPR3	P25089	406
OR7D4	SLC12A6	Q9UHW9	405
OR7D4	RTP1	P59025	401
OR7D4	TAS2R38	P59533	400
OR7D4	TAS2R10	Q9NYW0	399
OR7D4	CCER1	Q8TC90	391
OR7D4	SYNE1	Q8NF91	389
OR7D4	RTP2	Q5QGT7	377
OR7D4	F2Z2I4	F2Z2I4	369
OR7D4	DEFB130A	P0DP74	368
OR7D4	CHRM4	P08173	353

IntAct

15 interactions, top by confidence:

A	B	Type	Score
OR7D4	UBQLN2	psi-mi:“MI:0915”(physical association)	0.560
TUSC5	OR7D4	psi-mi:“MI:0915”(physical association)	0.560
SLC10A6	OR7D4	psi-mi:“MI:0915”(physical association)	0.560
OR7D4	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	OR7D4	psi-mi:“MI:0915”(physical association)	0.370
OR7D4	UBQLN2	psi-mi:“MI:0915”(physical association)	0.000
TUSC5	OR7D4	psi-mi:“MI:0915”(physical association)	0.000
OR7D4	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (3): OR7D4 (Two-hybrid), TUSC5 (Two-hybrid), UBQLN2 (Two-hybrid)

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

389 predictions. Top by Δscore:

Variant	Effect	Δscore
19:9214158:C:A	donor_gain	0.6800
19:9214135:A:AC	donor_gain	0.6700
19:9214136:C:CC	donor_gain	0.6700
19:9214157:T:A	donor_gain	0.6600
19:9214691:G:T	donor_gain	0.6500
19:9214238:A:C	acceptor_gain	0.6300
19:9214590:A:AC	donor_gain	0.6300
19:9214591:C:CC	donor_gain	0.6300
19:9214432:TGATG:T	donor_gain	0.6100
19:9214082:A:C	acceptor_gain	0.6000
19:9213951:T:TA	donor_gain	0.5900
19:9214436:G:T	donor_gain	0.5800
19:9214688:G:C	donor_gain	0.5800
19:9214007:CA:C	donor_gain	0.5600
19:9214434:A:AC	donor_gain	0.5600
19:9214007:CATCA:C	donor_gain	0.5500
19:9214160:C:T	acceptor_gain	0.5500
19:9214006:A:AC	donor_gain	0.5400
19:9214007:C:CC	donor_gain	0.5400
19:9214215:A:T	donor_gain	0.5400
19:9214235:CACA:C	acceptor_gain	0.5400
19:9214282:TGAGG:T	donor_gain	0.5400
19:9214139:GC:G	donor_gain	0.5300
19:9214140:CC:C	donor_gain	0.5300
19:9214240:A:AC	donor_gain	0.5300
19:9214241:C:CC	donor_gain	0.5300
19:9214241:CAAGA:C	donor_gain	0.5300
19:9214833:T:TA	donor_gain	0.5300
19:9214591:CTAG:C	donor_gain	0.5200
19:9213933:T:A	donor_gain	0.5100

AlphaMissense

2036 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:9214802:A:C	F12L	0.842
19:9214802:A:T	F12L	0.842
19:9214804:A:G	F12L	0.842
19:9214085:G:C	F251L	0.807
19:9214085:G:T	F251L	0.807
19:9214087:A:G	F251L	0.807
19:9214334:G:C	F168L	0.807
19:9214334:G:T	F168L	0.807
19:9214336:A:G	F168L	0.807
19:9213965:G:C	S291R	0.801
19:9213965:G:T	S291R	0.801
19:9213967:T:G	S291R	0.801
19:9214484:C:A	M118I	0.763
19:9214484:C:G	M118I	0.763
19:9214484:C:T	M118I	0.763
19:9213974:G:C	F288L	0.753
19:9213974:G:T	F288L	0.753
19:9213976:A:G	F288L	0.753
19:9214473:C:G	R122P	0.746
19:9214624:A:G	C72R	0.728
19:9214745:G:C	F31L	0.719
19:9214745:G:T	F31L	0.719
19:9214747:A:G	F31L	0.719
19:9214469:A:C	F123L	0.716
19:9214469:A:T	F123L	0.716
19:9214471:A:G	F123L	0.716
19:9214307:G:C	F177L	0.714
19:9214307:G:T	F177L	0.714
19:9214309:A:G	F177L	0.714
19:9214712:G:C	N42K	0.710

dbSNP variants (sampled 300 via entrez): RS1000162779 (19:9215690 T>C), RS1000518761 (19:9220454 A>G), RS1000622302 (19:9221070 C>A,G,T), RS1000692714 (19:9221456 T>A), RS1001047207 (19:9215164 G>A,T), RS1001076415 (19:9215012 T>C), RS1001218196 (19:9210993 G>T), RS1001388855 (19:9216418 A>T), RS1001568538 (19:9215029 A>G), RS1001689070 (19:9210575 C>T), RS1002761752 (19:9218272 C>T), RS1002954622 (19:9212203 G>A), RS1003293313 (19:9212407 A>G), RS1003427138 (19:9218587 T>C), RS1003665954 (19:9213319 G>A)

Disease associations

OMIM: gene MIM:611538 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Endosulfan	decreases expression	1
Sodium Selenite	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.