OR7E24

Summary

OR7E24 (olfactory receptor family 7 subfamily E member 24, HGNC:8396) is a protein-coding gene on chromosome 19p13.2, encoding Olfactory receptor 7E24 (Q6IFN5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26648 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_001079935

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8396
Approved symbol	OR7E24
Name	olfactory receptor family 7 subfamily E member 24
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	OR19-8, HSHT2, OR7E24Q
Ensembl gene	ENSG00000237521
Ensembl biotype	protein_coding
Entrez	26648

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000456448, ENST00000641946

RefSeq mRNA: 2 — MANE Select: NM_001079935 NM_001079935, NM_001386108

CCDS: CCDS45955, CCDS92506

Canonical transcript exons

ENST00000456448 — 1 exons

Exon	Start	End
ENSE00001701653	9250930	9252625

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 86.39.

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	86.39	gold quality
secondary oocyte	CL:0000655	85.41	gold quality
frontal pole	UBERON:0002795	65.12	gold quality
middle frontal gyrus	UBERON:0002702	64.80	gold quality
paraflocculus	UBERON:0005351	64.73	gold quality
sperm	CL:0000019	63.79	gold quality
male germ cell	CL:0000015	62.83	gold quality
endometrium epithelium	UBERON:0004811	61.13	gold quality
cerebellar vermis	UBERON:0004720	56.27	gold quality
upper leg skin	UBERON:0004262	56.17	gold quality
pancreatic ductal cell	CL:0002079	56.14	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	54.38	gold quality
cranial nerve II	UBERON:0000941	53.03	gold quality
ileal mucosa	UBERON:0000331	51.96	silver quality
left testis	UBERON:0004533	51.57	gold quality
quadriceps femoris	UBERON:0001377	51.29	gold quality
right testis	UBERON:0004534	51.25	gold quality
Brodmann (1909) area 10	UBERON:0013541	51.05	gold quality
deltoid	UBERON:0001476	51.01	silver quality
epithelial cell of pancreas	CL:0000083	50.53	gold quality
testis	UBERON:0000473	50.38	gold quality
vastus lateralis	UBERON:0001379	50.05	gold quality
thymus	UBERON:0002370	49.41	gold quality
Brodmann (1909) area 46	UBERON:0006483	49.30	gold quality
blood vessel layer	UBERON:0004797	49.29	gold quality
metanephric glomerulus	UBERON:0004736	49.21	gold quality
cervix squamous epithelium	UBERON:0006922	49.20	gold quality
hair follicle	UBERON:0002073	49.18	gold quality
olfactory bulb	UBERON:0002264	48.92	gold quality
choroid plexus epithelium	UBERON:0003911	48.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.12

Regulation

Is transcription factor: no

Cross-species orthologs

14 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or7e174	ENSMUSG00000044106
mus_musculus	Or7e177	ENSMUSG00000049028
mus_musculus	Or7e173	ENSMUSG00000050803
mus_musculus	Or7e175	ENSMUSG00000058491
mus_musculus	Or7e176	ENSMUSG00000066897
rattus_norvegicus		ENSRNOG00000066601
rattus_norvegicus	Or7e176	ENSRNOG00000070602
rattus_norvegicus	Or7e174	ENSRNOG00000071781
rattus_norvegicus	Or7e173	ENSRNOG00000071834
rattus_norvegicus		ENSRNOG00000074671
rattus_norvegicus	Olr1177	ENSRNOG00000079316
rattus_norvegicus	Or7e173d	ENSRNOG00000080580
rattus_norvegicus		ENSRNOG00000089018
rattus_norvegicus	Or7e176b	ENSRNOG00000090996

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 7E24 — Q6IFN5 (reviewed: Q6IFN5)

Alternative names: Olfactory receptor OR19-14

All UniProt accessions (2): A0A2R8Y4Q1, Q6IFN5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001073404, NP_001373037 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6IFN5-F1	84.78	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 115–207

Glycosylation sites (1): 23

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 36 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, HUTTMANN_B_CLL_POOR_SURVIVAL_UP, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_B

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

212 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR7E24	EXOC3L4	Q17RC7	562
OR7E24	MYO15B	Q96JP2	499
OR7E24	SPACA6	W5XKT8	480
OR7E24	TMEM184C	Q9NVA4	460
OR7E24	GPSM1	Q86YR5	407
OR7E24	CCDC178	Q5BJE1	397
OR7E24	LRTM3	Q8NDH2	392
OR7E24	CNGA2	Q16280	331
OR7E24	GNG8	Q9UK08	322
OR7E24	ASTE1	Q2TB18	322
OR7E24	TMC5	Q6UXY8	320
OR7E24	GBP6	Q6ZN66	319
OR7E24	USF3	Q68DE3	314
OR7E24	ANO2	Q9NQ90	306
OR7E24	SPOUT1	Q5T280	300

IntAct

7 interactions, top by confidence:

A	B	Type	Score
OR7E24	ACTA2	psi-mi:“MI:0915”(physical association)	0.400
OR7E24	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	OR7E24	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (2): ACTA2 (Affinity Capture-MS), OR7E24 (Negative Genetic)

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A4D2G3, A6ND48, A6NL26, O43749, O60412, O76099, P0C7N5, P0DMU2, P0DN82, P23265, P23266, P23269, P23272, P23273, P23274, P30953, P30955, P34984, P34985, P34986, P35896, P47887, P47890, P58173, P58181, P58182, P70526, Q0VAX9, Q13606, Q13607, Q15617, Q15619, Q60893, Q6IFN5, Q6UXT6, Q7TQQ0, Q7TRF3, Q8N127, Q8NG98, Q8NGA6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	59
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

293 predictions. Top by Δscore:

Variant	Effect	Δscore
19:9250962:G:GT	donor_gain	0.8700
19:9250961:GGGT:G	donor_gain	0.7100
19:9250973:C:CG	donor_gain	0.7100
19:9250976:T:G	donor_gain	0.6200
19:9251422:T:G	acceptor_gain	0.6100
19:9250973:C:G	donor_gain	0.5900
19:9251080:AAAAG:A	acceptor_gain	0.5800
19:9251330:TCCCC:T	donor_gain	0.5600
19:9250962:G:T	donor_gain	0.5400
19:9251084:GGT:G	acceptor_gain	0.5400
19:9251426:T:G	acceptor_gain	0.5400
19:9251215:C:CG	donor_gain	0.5300
19:9251900:CCAG:C	acceptor_loss	0.5300
19:9251901:CA:C	acceptor_loss	0.5300
19:9251902:A:C	acceptor_loss	0.5300
19:9251903:GGA:G	acceptor_loss	0.5300
19:9251080:A:AG	acceptor_gain	0.5200
19:9251209:ACG:A	donor_gain	0.5200
19:9251895:A:AG	acceptor_loss	0.5200
19:9251896:T:G	acceptor_loss	0.5200
19:9251892:A:AG	acceptor_loss	0.5100
19:9251893:C:G	acceptor_loss	0.5100
19:9251992:A:G	donor_gain	0.5100
19:9250981:A:G	donor_gain	0.5000
19:9251081:A:G	acceptor_gain	0.4900
19:9251083:A:AG	acceptor_gain	0.4900
19:9251084:G:GG	acceptor_gain	0.4900
19:9251421:AT:A	acceptor_gain	0.4900
19:9250967:A:G	donor_gain	0.4800
19:9250977:G:GG	donor_gain	0.4700

AlphaMissense

2245 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:9251131:T:C	F30L	0.887
19:9251133:C:A	F30L	0.887
19:9251133:C:G	F30L	0.887
19:9251848:T:C	F269L	0.854
19:9251850:T:A	F269L	0.854
19:9251850:T:G	F269L	0.854
19:9251551:A:C	S170R	0.830
19:9251553:T:A	S170R	0.830
19:9251553:T:G	S170R	0.830
19:9251464:T:C	F141L	0.815
19:9251466:T:A	F141L	0.815
19:9251466:T:G	F141L	0.815
19:9251451:G:A	M136I	0.810
19:9251451:G:C	M136I	0.810
19:9251451:G:T	M136I	0.810
19:9251959:T:C	F306L	0.788
19:9251961:C:A	F306L	0.788
19:9251961:C:G	F306L	0.788
19:9251809:T:C	F256L	0.780
19:9251811:C:A	F256L	0.780
19:9251811:C:G	F256L	0.780
19:9251188:T:C	F49L	0.778
19:9251190:C:A	F49L	0.778
19:9251190:C:G	F49L	0.778
19:9251626:T:C	F195L	0.771
19:9251628:C:A	F195L	0.771
19:9251628:C:G	F195L	0.771
19:9251223:C:A	N60K	0.767
19:9251223:C:G	N60K	0.767
19:9251462:G:C	R140P	0.763

dbSNP variants (sampled 300 via entrez): RS1000046280 (19:9231787 A>G), RS1000158473 (19:9241502 A>C), RS1000162779 (19:9215690 T>C), RS1000185343 (19:9209656 T>A), RS1000239318 (19:9225549 G>T), RS1000311394 (19:9225311 A>G), RS1000343010 (19:9249200 A>G), RS1000380054 (19:9242608 C>A), RS1000445685 (19:9242904 TTC>T), RS1000476084 (19:9243503 C>T), RS1000518761 (19:9220454 A>G), RS1000552878 (19:9225497 TAAAA>T,TAAA,TAAAAA), RS1000622302 (19:9221070 C>A,G,T), RS1000683558 (19:9248930 C>G,T), RS1000692714 (19:9221456 T>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (1): CIC-rearranged sarcoma (MONDO:0956989)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic	affects methylation	1
Tretinoin	decreases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

3 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02389244	PHASE2	ACTIVE_NOT_RECRUITING	A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas
NCT06414434	PHASE1	ACTIVE_NOT_RECRUITING	BTX-A51 in Patients With Liposarcoma or CIC-rearranged Sarcoma
NCT06820957	PHASE2/PHASE3	ACTIVE_NOT_RECRUITING	Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body