OR7G1

Summary

OR7G1 (olfactory receptor family 7 subfamily G member 1, HGNC:8465) is a protein-coding gene on chromosome 19p13.2, encoding Olfactory receptor 7G1 (Q8NGA0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 125962 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 51 total
• MANE Select transcript: NM_001005192

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8465
Approved symbol	OR7G1
Name	olfactory receptor family 7 subfamily G member 1
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	OR19-15
Ensembl gene	ENSG00000161807
Ensembl biotype	protein_coding
Entrez	125962

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000541538

RefSeq mRNA: 1 — MANE Select: NM_001005192 NM_001005192

CCDS: CCDS32898

Canonical transcript exons

ENST00000541538 — 1 exons

Exon	Start	End
ENSE00002262061	9114828	9115763

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.87.

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	37.87	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
leukocyte	CL:0000738	27.95	gold quality
lymph node	UBERON:0000029	27.57	gold quality
monocyte	CL:0000576	27.33	gold quality
urinary bladder	UBERON:0001255	27.31	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.01	gold quality
fundus of stomach	UBERON:0001160	24.66	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
pancreas	UBERON:0001264	24.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.14

Regulation

Is transcription factor: no

Cross-species orthologs

13 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or7g25	ENSMUSG00000048391
mus_musculus	Or7g17	ENSMUSG00000051414
mus_musculus	Or7g31	ENSMUSG00000094535
mus_musculus	Or7g34	ENSMUSG00000095667
rattus_norvegicus	Or7g23e	ENSRNOG00000039919
rattus_norvegicus	Or7g17	ENSRNOG00000051847
rattus_norvegicus	Or7g89	ENSRNOG00000070961
rattus_norvegicus	Or7g34b	ENSRNOG00000074850
rattus_norvegicus	Or7g23	ENSRNOG00000078257
rattus_norvegicus	Or7g23b	ENSRNOG00000078596
rattus_norvegicus	Or7g31	ENSRNOG00000080105
rattus_norvegicus	Or7g34	ENSRNOG00000080576
rattus_norvegicus	Or7g25	ENSRNOG00000089011

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 7G1 — Q8NGA0 (reviewed: Q8NGA0)

Alternative names: Olfactory receptor 19-15, Olfactory receptor OR19-8

All UniProt accessions (2): A0A126GVS6, Q8NGA0

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005192* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (24 total): topological domain 8, transmembrane region 7, sequence variant 5, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGA0-F1	89.46	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Glycosylation sites (2): 5, 89

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of chemical stimulus (GO:0007606), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

178 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR7G1	ZNF781	Q8N8C0	507
OR7G1	CALHM3	Q86XJ0	473
OR7G1	ZNF699	Q32M78	434
OR7G1	KRTAP19-8	Q3LI54	430
OR7G1	HABP4	Q5JVS0	377
OR7G1	OR8B8	Q15620	365
OR7G1	STK17A	Q9UEE5	323
OR7G1	KRTAP5-7	Q6L8G8	321
OR7G1	OR4D6	Q8NGJ1	310
OR7G1	TAS2R42	Q7RTR8	273
OR7G1	CST6	Q15828	272
OR7G1	SCN2B	O60939	271
OR7G1	KRTAP5-11	Q6L8G4	258
OR7G1	LLPH	Q9BRT6	257
OR7G1	KRTAP5-5	Q701N2	253

IntAct

7 interactions, top by confidence:

A	B	Type	Score
OR7G1	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	OR7G1	psi-mi:“MI:0915”(physical association)	0.370
NEK4	E2F8	psi-mi:“MI:0914”(association)	0.350

BioGRID (3): OR7G1 (Affinity Capture-MS), OR7G1 (Cross-Linking-MS (XL-MS)), SNRPD2 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A0A3B3IT45, A6NGY5, A6NMU1, A6NND4, O43749, O60431, O88628, P0C626, P0C646, P0C7T3, P0DN81, P23266, P23272, P23273, P23274, P30953, P30955, P58181, P70526, Q13607, Q6IF63, Q6IFG1, Q6W049, Q8NG95, Q8NG99, Q8NGA0, Q8NGA1, Q8NGC4, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	48
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

280 predictions. Top by Δscore:

Variant	Effect	Δscore
19:9115008:A:C	acceptor_gain	0.7700
19:9115006:CCA:C	acceptor_gain	0.7400
19:9115007:CA:C	acceptor_gain	0.7400
19:9115100:C:CC	acceptor_gain	0.7200
19:9115007:C:T	acceptor_gain	0.7100
19:9115005:CCCA:C	acceptor_gain	0.7000
19:9115008:A:AC	acceptor_gain	0.6900
19:9115208:TGATG:T	donor_gain	0.6500
19:9115014:C:CT	acceptor_gain	0.6300
19:9115694:T:TA	donor_gain	0.6200
19:9115159:G:A	donor_gain	0.5900
19:9115065:T:A	donor_gain	0.5800
19:9115001:C:CC	acceptor_gain	0.5700
19:9115691:A:C	donor_gain	0.5700
19:9115155:A:AC	donor_gain	0.5500
19:9115156:C:CC	donor_gain	0.5500
19:9115151:CACTA:C	donor_gain	0.5400
19:9115015:A:T	acceptor_gain	0.5300
19:9115097:TGA:T	acceptor_gain	0.5300
19:9115096:GTGA:G	acceptor_gain	0.5200
19:9115222:ACTT:A	acceptor_gain	0.5200
19:9115223:CTTC:C	acceptor_gain	0.5200
19:9115098:GA:G	acceptor_gain	0.5100
19:9115588:A:C	donor_gain	0.5100
19:9115718:T:A	donor_gain	0.5000
19:9115104:T:C	acceptor_gain	0.4900
19:9115153:C:CT	donor_gain	0.4900
19:9115154:T:TT	donor_gain	0.4900
19:9114857:T:TA	donor_gain	0.4800
19:9115061:A:AC	donor_gain	0.4700

AlphaMissense

2048 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:9115728:A:C	F12L	0.848
19:9115728:A:T	F12L	0.848
19:9115730:A:G	F12L	0.848
19:9115260:G:C	F168L	0.817
19:9115260:G:T	F168L	0.817
19:9115262:A:G	F168L	0.817
19:9115230:G:C	F178L	0.759
19:9115230:G:T	F178L	0.759
19:9115232:A:G	F178L	0.759
19:9115011:G:C	F251L	0.754
19:9115011:G:T	F251L	0.754
19:9115013:A:G	F251L	0.754
19:9115050:A:C	F238L	0.753
19:9115050:A:T	F238L	0.753
19:9115052:A:G	F238L	0.753
19:9114900:G:C	F288L	0.725
19:9114900:G:T	F288L	0.725
19:9114902:A:G	F288L	0.725
19:9115680:G:C	F28L	0.719
19:9115680:G:T	F28L	0.719
19:9115682:A:G	F28L	0.719
19:9115671:G:C	F31L	0.708
19:9115671:G:T	F31L	0.708
19:9115673:A:G	F31L	0.708
19:9115233:G:C	F177L	0.697
19:9115233:G:T	F177L	0.697
19:9115235:A:G	F177L	0.697
19:9115284:A:C	S160R	0.655
19:9115284:A:T	S160R	0.655
19:9115286:T:G	S160R	0.655

dbSNP variants (sampled 300 via entrez): RS1000414181 (19:9116799 C>A,T), RS1001850876 (19:9117701 G>A), RS1002910713 (19:9114580 G>A), RS1003120788 (19:9116514 GA>G,GAA), RS1003561472 (19:9116829 A>G), RS1003840717 (19:9115981 G>A), RS1003966368 (19:9116269 C>T), RS1005371213 (19:9117437 T>C), RS1008045655 (19:9115330 A>G), RS1008514164 (19:9115571 T>C), RS1009100448 (19:9117153 C>G,T), RS1009462747 (19:9116849 T>C), RS1010753993 (19:9115617 G>A), RS1011560682 (19:9115149 T>C), RS1011728645 (19:9116891 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003542_87	Night sleep phenotypes	5.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression, increases abundance	1
Valproic Acid	increases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.