OR7G2

Summary

OR7G2 (olfactory receptor family 7 subfamily G member 2, HGNC:8466) is a protein-coding gene on chromosome 19p13.2, encoding Olfactory receptor 7G2 (Q8NG99). Odorant receptor. It is a selective cancer dependency (DepMap: 16.0% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390882 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 54 total
• Cancer dependency (DepMap): dependent in 16.0% of screened cell lines
• MANE Select transcript: NM_001005193

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8466
Approved symbol	OR7G2
Name	olfactory receptor family 7 subfamily G member 2
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	OST260
Ensembl gene	ENSG00000170923
Ensembl biotype	protein_coding
Entrez	390882

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641081

RefSeq mRNA: 1 — MANE Select: NM_001005193 NM_001005193

CCDS: CCDS32897

Canonical transcript exons

ENST00000641081 — 2 exons

Exon	Start	End
ENSE00003811808	9107314	9107475
ENSE00003811966	9100407	9103259

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 41.68.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	41.68	gold quality
colonic epithelium	UBERON:0000397	41.02	gold quality
sural nerve	UBERON:0015488	40.86	gold quality
popliteal artery	UBERON:0002250	40.75	silver quality
tibial artery	UBERON:0007610	40.71	silver quality
granulocyte	CL:0000094	40.39	gold quality
ventricular zone	UBERON:0003053	40.15	gold quality
stromal cell of endometrium	CL:0002255	39.58	gold quality
smooth muscle tissue	UBERON:0001135	38.39	gold quality
leukocyte	CL:0000738	38.33	gold quality
monocyte	CL:0000576	38.11	gold quality
lower esophagus mucosa	UBERON:0035834	38.10	gold quality
bone marrow	UBERON:0002371	37.88	gold quality
muscle tissue	UBERON:0002385	36.65	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
blood	UBERON:0000178	36.08	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
liver	UBERON:0002107	35.29	gold quality
skeletal muscle tissue	UBERON:0001134	34.80	gold quality
mucosa of transverse colon	UBERON:0004991	34.51	gold quality
ascending aorta	UBERON:0001496	33.84	gold quality
thoracic aorta	UBERON:0001515	33.73	gold quality
primary visual cortex	UBERON:0002436	33.19	gold quality
body of pancreas	UBERON:0001150	32.93	gold quality
lower esophagus	UBERON:0013473	32.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	32.68	gold quality
ovary	UBERON:0000992	32.56	gold quality
right lobe of liver	UBERON:0001114	32.49	gold quality
subcutaneous adipose tissue	UBERON:0002190	32.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.09

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 16.0% of screened cell lines.

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or7g20	ENSMUSG00000045204
mus_musculus	Or7g28	ENSMUSG00000058692
mus_musculus	Or7g29	ENSMUSG00000059821
mus_musculus	Or7g27	ENSMUSG00000061614
mus_musculus	Or7g16	ENSMUSG00000078116
rattus_norvegicus	Or7g16	ENSRNOG00000006439
rattus_norvegicus	Or7g29	ENSRNOG00000006577
rattus_norvegicus	Or7g41	ENSRNOG00000030845
rattus_norvegicus	Or7g20	ENSRNOG00000076463

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 7G2 — Q8NG99 (reviewed: Q8NG99)

Alternative names: OST260, Olfactory receptor 19-13, Olfactory receptor OR19-6

All UniProt accessions (2): A0A126GW43, Q8NG99

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005193* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NG99-F1	85.65	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 5, 89

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 21 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_DN, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_A, RAO_BOUND_BY_SALL4_ISOFORM_B

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

130 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR7G2	KANSL1L	A0AUZ9	513
OR7G2	LRRC45	Q96CN5	459
OR7G2	MMP27	Q9H306	429
OR7G2	MRPS18B	Q9Y676	415
OR7G2	CFAP276	Q5T5A4	415
OR7G2	ANO7	Q6IWH7	399
OR7G2	L1TD1	Q5T7N2	396
OR7G2	PARP8	Q8N3A8	374
OR7G2	RPTN	Q6XPR3	371
OR7G2	BHLHE22	Q8NFJ8	363
OR7G2	ARHGEF40	Q8TER5	344
OR7G2	MLF1	P58340	321
OR7G2	NACC1	Q96RE7	306
OR7G2	FOXE3	Q13461	302
OR7G2	CATSPERT	Q53TS8	288

IntAct

6 interactions, top by confidence:

A	B	Type	Score
OR7G2	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	OR7G2	psi-mi:“MI:0915”(physical association)	0.370

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A0A3B3IT45, A6NGY5, A6NMU1, A6NND4, O43749, O60431, O88628, P0C626, P0C646, P0C7T3, P0DN81, P23266, P23272, P23273, P23274, P30953, P30955, P58181, P70526, Q13607, Q6IF63, Q6IFG1, Q6W049, Q8NG95, Q8NG99, Q8NGA0, Q8NGA1, Q8NGC4, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

412 predictions. Top by Δscore:

Variant	Effect	Δscore
19:9102984:G:C	donor_gain	0.7300
19:9103240:C:A	donor_gain	0.7200
19:9102938:G:C	donor_gain	0.7000
19:9103136:CAAG:C	donor_gain	0.6800
19:9103138:A:AC	donor_gain	0.6700
19:9102959:TGAG:T	donor_gain	0.6600
19:9102966:G:C	donor_gain	0.6600
19:9102878:G:C	donor_gain	0.6500
19:9102961:A:AC	donor_gain	0.6400
19:9102417:A:AC	donor_gain	0.6300
19:9102418:C:CC	donor_gain	0.6300
19:9102912:T:A	donor_gain	0.6200
19:9102964:A:AC	donor_gain	0.6200
19:9102965:C:CC	donor_gain	0.6200
19:9103144:TGG:T	donor_gain	0.6200
19:9102955:AG:A	donor_gain	0.6100
19:9103135:CCAA:C	donor_gain	0.6100
19:9103143:A:C	donor_gain	0.6100
19:9102956:G:GA	donor_gain	0.6000
19:9102413:CA:C	donor_gain	0.5700
19:9102483:G:A	donor_gain	0.5700
19:9102886:AGG:A	donor_gain	0.5700
19:9102362:ATT:A	donor_gain	0.5600
19:9102413:CATCA:C	donor_gain	0.5600
19:9103154:CAGG:C	donor_gain	0.5600
19:9102957:CCTGA:C	donor_gain	0.5500
19:9103185:T:TA	donor_gain	0.5500
19:9102532:CTG:C	donor_gain	0.5400
19:9102677:A:C	donor_gain	0.5400
19:9102392:C:CT	acceptor_gain	0.5300

AlphaMissense

2110 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:9103208:G:C	F12L	0.855
19:9103208:G:T	F12L	0.855
19:9103210:A:G	F12L	0.855
19:9102740:G:C	F168L	0.817
19:9102740:G:T	F168L	0.817
19:9102742:A:G	F168L	0.817
19:9103022:G:C	S74R	0.802
19:9103022:G:T	S74R	0.802
19:9103024:T:G	S74R	0.802
19:9102491:G:C	F251L	0.793
19:9102491:G:T	F251L	0.793
19:9102493:A:G	F251L	0.793
19:9102710:G:C	F178L	0.773
19:9102710:G:T	F178L	0.773
19:9102712:A:G	F178L	0.773
19:9102879:C:G	R122P	0.757
19:9102788:A:C	S152R	0.754
19:9102788:A:T	S152R	0.754
19:9102790:T:G	S152R	0.754
19:9102713:G:C	F177L	0.748
19:9102713:G:T	F177L	0.748
19:9102715:A:G	F177L	0.748
19:9102890:C:A	M118I	0.743
19:9102890:C:G	M118I	0.743
19:9102890:C:T	M118I	0.743
19:9102380:A:C	F288L	0.727
19:9102380:A:T	F288L	0.727
19:9102382:A:G	F288L	0.727
19:9102371:A:C	S291R	0.724
19:9102371:A:T	S291R	0.724

dbSNP variants (sampled 300 via entrez): RS1000041975 (19:9104658 T>C), RS1000093746 (19:9104881 G>A), RS1000941627 (19:9100320 G>A,C), RS1001099250 (19:9106337 A>C,G), RS1001528959 (19:9101787 A>G), RS1001560574 (19:9101496 C>A), RS1002065614 (19:9107441 G>A), RS1002087306 (19:9107868 G>A), RS1002116379 (19:9107628 T>C), RS1002459395 (19:9107662 C>T), RS1003070552 (19:9109331 G>A), RS1003206201 (19:9100338 A>G), RS1003237547 (19:9100654 G>A,T), RS1004569096 (19:9105988 TAC>T), RS1004677393 (19:9099954 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003542_87	Night sleep phenotypes	5.000000e-06
GCST011053_12	Neuroblastoma (pediatric)	2.000000e-13

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
butylbenzyl phthalate	increases expression	1
Benzo(a)pyrene	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.