OR7G3

Summary

OR7G3 (olfactory receptor family 7 subfamily G member 3, HGNC:8467) is a protein-coding gene on chromosome 19p13.2, encoding Olfactory receptor 7G3 (Q8NG95). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390883 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 34 total
• MANE Select transcript: NM_001001958

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8467
Approved symbol	OR7G3
Name	olfactory receptor family 7 subfamily G member 3
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	OST085
Ensembl gene	ENSG00000170920
Ensembl biotype	protein_coding
Entrez	390883

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000305444

RefSeq mRNA: 1 — MANE Select: NM_001001958 NM_001001958

CCDS: CCDS32899

Canonical transcript exons

ENST00000305444 — 1 exons

Exon	Start	End
ENSE00001153918	9126012	9126950

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 37.20.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
right uterine tube	UBERON:0001302	30.93	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
monocyte	CL:0000576	27.68	gold quality
leukocyte	CL:0000738	27.67	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.01	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.74	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
frontal cortex	UBERON:0001870	24.32	gold quality
pancreas	UBERON:0001264	24.28	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The SNP in the OR7G3 gene (rs10414255) was found to be associated with adiposity and eating behaviors. (PMID:22044667)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or7g12	ENSMUSG00000095525
mus_musculus	Or7g19	ENSMUSG00000095957
rattus_norvegicus	Or7g12	ENSRNOG00000026489

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 7G3 — Q8NG95 (reviewed: Q8NG95)

Alternative names: OST085, Olfactory receptor OR19-9

All UniProt accessions (2): A0A126GVR4, Q8NG95

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001958* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NG95-F1	87.67	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 5, 93

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, PEDRIOLI_MIR31_TARGETS_UP, ZNF512_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of chemical stimulus (GO:0007606), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

152 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR7G3	FAM187B	Q17R55	730
OR7G3	SLC22A24	Q8N4F4	626
OR7G3	CBY2	Q8NA61	602
OR7G3	ZNF80	P51504	561
OR7G3	ABCA10	Q8WWZ4	542
OR7G3	C15orf40	Q8WUR7	542
OR7G3	CCHCR1	Q8TD31	535
OR7G3	EFCAB13	Q8IY85	446
OR7G3	KRT83	P78385	429
OR7G3	RFPL1	O75677	419
OR7G3	CIMIP1	Q9H1P6	419
OR7G3	ZNF543	Q08ER8	416
OR7G3	SLC22A10	Q63ZE4	415
OR7G3	SOWAHC	Q53LP3	405
OR7G3	TMEM232	C9JQI7	397

IntAct

6 interactions, top by confidence:

A	B	Type	Score
OR7G3	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	OR7G3	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (1): OR7G3 (Reconstituted Complex)

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A3KFT3, A6NH00, A6NM03, O43749, O43869, O95006, O95371, O95918, P0C7N1, P0C7N5, P0C7T2, P0DN81, P23274, P23275, P30955, P34984, P47890, P58181, P70526, Q13607, Q5TZ20, Q60880, Q6IEZ7, Q6IF00, Q6UXT6, Q8N349, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG95, Q8NG97, Q8NGF4, Q8NGH3, Q8NGQ1, Q8NGR2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	28
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

340 predictions. Top by Δscore:

Variant	Effect	Δscore
19:9126748:A:T	acceptor_gain	0.7500
19:9126747:C:CT	acceptor_gain	0.7300
19:9126186:CC:C	acceptor_gain	0.6900
19:9126187:CC:C	acceptor_gain	0.6900
19:9126210:A:AT	donor_gain	0.6900
19:9126209:C:CT	donor_gain	0.6400
19:9126252:T:A	donor_gain	0.6400
19:9126663:G:GA	donor_gain	0.6400
19:9126691:G:A	donor_gain	0.6400
19:9126251:TTCC:T	donor_gain	0.6300
19:9126636:C:CT	acceptor_gain	0.6300
19:9126335:A:C	donor_gain	0.6200
19:9126250:TTTC:T	donor_gain	0.6100
19:9126248:A:AC	donor_gain	0.6000
19:9126249:C:CC	donor_gain	0.6000
19:9126553:TTGTA:T	donor_loss	0.6000
19:9126554:TGTAC:T	donor_loss	0.6000
19:9126555:GTAC:G	donor_loss	0.6000
19:9126556:TACCT:T	donor_loss	0.6000
19:9126557:A:C	donor_loss	0.6000
19:9126662:AG:A	donor_gain	0.5900
19:9126075:CAGG:C	acceptor_gain	0.5800
19:9126559:C:G	donor_loss	0.5800
19:9126252:TCC:T	donor_gain	0.5700
19:9126291:T:TA	donor_gain	0.5700
19:9126770:A:AC	donor_gain	0.5600
19:9126249:CTTT:C	donor_gain	0.5500
19:9126253:C:CT	donor_gain	0.5500
19:9126312:C:A	donor_gain	0.5500
19:9126336:CAGG:C	donor_gain	0.5400

AlphaMissense

2026 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:9126447:G:C	F168L	0.840
19:9126447:G:T	F168L	0.840
19:9126449:A:G	F168L	0.840
19:9126198:A:C	F251L	0.820
19:9126198:A:T	F251L	0.820
19:9126200:A:G	F251L	0.820
19:9126915:G:C	F12L	0.796
19:9126915:G:T	F12L	0.796
19:9126917:A:G	F12L	0.796
19:9126582:A:C	F123L	0.758
19:9126582:A:T	F123L	0.758
19:9126584:A:G	F123L	0.758
19:9126417:G:C	F178L	0.757
19:9126417:G:T	F178L	0.757
19:9126419:A:G	F178L	0.757
19:9126420:A:C	F177L	0.756
19:9126420:A:T	F177L	0.756
19:9126422:A:G	F177L	0.756
19:9126858:G:C	F31L	0.734
19:9126858:G:T	F31L	0.734
19:9126860:A:G	F31L	0.734
19:9126237:A:C	F238L	0.713
19:9126237:A:T	F238L	0.713
19:9126239:A:G	F238L	0.713
19:9126495:A:C	S152R	0.700
19:9126495:A:T	S152R	0.700
19:9126497:T:G	S152R	0.700
19:9126339:G:C	S204R	0.695
19:9126339:G:T	S204R	0.695
19:9126341:T:G	S204R	0.695

dbSNP variants (sampled 300 via entrez): RS1000194749 (19:9128089 G>A), RS1000369813 (19:9126050 A>G), RS1000808380 (19:9127882 C>T), RS1001241043 (19:9128879 C>A), RS1003317177 (19:9125865 C>T), RS1003319632 (19:9127476 T>C), RS1003480846 (19:9127259 TTC>T), RS1004730673 (19:9127474 C>T), RS1005283013 (19:9128673 A>T), RS1005790139 (19:9128881 C>A,G,T), RS1005992056 (19:9125764 A>G), RS1008412288 (19:9128295 C>T), RS1008918452 (19:9126904 C>A,T), RS1009423289 (19:9127518 T>G), RS1009455683 (19:9127842 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003542_87	Night sleep phenotypes	5.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	increases reaction, affects binding	1
Benzo(a)pyrene	decreases methylation, increases methylation	1
Diethylhexyl Phthalate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.